Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress

Lagunas, Natalia; Calmarza-Font, Isabel; Diz-Chaves, Yolanda; Garcia-Segura, Luis Miguel

doi:10.1016/j.yhbeh.2010.07.014

Cited by 92 publications

(83 citation statements)

References 83 publications

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“…Contrary to observations reported previously (Lagunas et al, 2010), the ovariectomy did not cause any behavioural modification in the EPM or open field tests. However, considering that many pharmacological treatments of obesity cause several adverse effects to the body, including an increase in anxiety and in general activity (Ioannides-Demos et al, 2011;Carter et al, 2012;Haslam, 2016;Nuffer et al, 2016), it has become of extreme importance to verify if the preparations of A. sisalana that cause weight loss modify the anxiety profile or cause motor disorders.…”

Section: Discussioncontrasting

confidence: 99%

Preliminary phytochemical analysis and the effect of Agave sisalana on body weight and defensive behaviours in ovariectomized rats

Andrade¹,

Silva²,

Espinoza³

et al. 2017

J. Med. Plants Res.

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Agave sisalana is a plant belonging to the Agavaceae family. Sisal juice is constituted of steroidic saponins which are precursor molecules of many pharmacologically active steroids. These precursor molecules can act in brain structures that are related to the modulation of emotional disorders. They can act on energy metabolism or directly on the absorptive process of fats. The objective of this research was to identify the biocompounds present in A. sisalana juice, and to evaluate the effect of different extracts on the expression of defensive behaviours of rats in elevated plus maze and open field tests, and body weight, in a condition that corresponds to an induced menopause. Wistar rats were subjected to bilateral ovariectomy or to a sham surgical procedure under anaesthesia. Following surgery, they were treated gavage with sisal juice -concentrated crude juice (CCJ): 500 or 1000 mg/kg; dried extract (DE): 50, 100 or 200 mg/kg; dry mucilage extract (DME): 25, 50 or 100 mg/kg; and intermediate product (IP): 25, 50 or 100 mg/kg; or distilled water. The results showed the presence of coumarins, flavonoids, condensed tannins, free anthraquinones, alkaloids and saponins in the sisal juice. Both CCJ and DE (100 mg/kg) caused weight loss without alteration of defensive behaviours related to the manifestation of anxiety. As saponins were identified in DE in significant amounts, the observed effects were attributed to this component. Such findings point to A. sisalana as a plant that could potentially be used to treat weight gain during menopause.

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Section: Discussioncontrasting

confidence: 99%

Preliminary phytochemical analysis and the effect of Agave sisalana on body weight and defensive behaviours in ovariectomized rats

Andrade¹,

Silva²,

Espinoza³

et al. 2017

J. Med. Plants Res.

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“…The apparent contradictions may be due in part to differences in the models used for different studies, and in differences in dose and time-frames in the behavioural studies (Lagunas et al , 2010).…”

Section: Discussionmentioning

confidence: 99%

Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol

Holm

Liang

Thorsell

et al. 2014

Pharmacology Biochemistry and Behavior

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Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol, 2014, Pharmacology, Biochemistry and Behavior, (122) Anxiety and panic-disorders are twice as common in females compared to males, but studies of females are rare, although increasing in number. Limited studies have found that CCK fluctuates in limbic regions during the estrous cycle, and that CCK and its receptors are sensitive to estrogen. Aim/Purpose: The aim of the present work was to study acute effects of 17β-estradiol on anxiety-like behaviour and effects on CCK-like immunoreactivity (LI) in the female rat brain (amygdala, hippocampus, nucleus accumbens, and cingulate cortex).Methods: Four groups of female Sprague-Dawley rats were used: ovariectomized, ovariectomized+17β-estradiol -replacement, sham, and sham+17β-estradiol -replacement. The effect of 17β-estradiol -replacement on anxiety-related behaviour was measured in all animals on the elevated plus maze 2 -24hr after injection. CCK-LI concentration was measured in punch biopsies by means of radioimmunoassay. Results Conclusion:Although the interpretation of these data requires caution since the data were collected from two different experiments, our results suggest that estrogen-induced anxiolytic effects may be associated with changes of the CCK-system in brain regions controlling anxiety-like behaviour.1

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“…In terms of hypogonadism, reduction or removal of estrogen and androgen, or the withdrawal of progesterone all resulted in increases in anxiety-like behaviours when compared to control subjects (de Chaves et al, 2009;Diz-Chaves et al, 2012;Gulinello et al, 2003;Isles et al, 2004;Lagunas et al, 2010;Lewejohann et al, 2009;Li et al, 2012;McDermott et al, 2012;Schneider and Popik, 2007;Slack et al, 2009;Wainwright et al, 2011;Walf et al, 2009). Measures of depressive-like behaviours were less consistent, for example, aged female rodents did not display increases in depressive-like symptoms when estradiol was absent (Diz-Chaves et al, 2012) though this effect differed depending on the age at ovariectomy and the duration of estradiol replacement (Lagunas et al, 2010). Inconsistencies were apparent as well in terms of the TFM rodent model.…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

“…In both humans and rodents, there is evidence for an interaction of the hippocampus and amygdala in anxiety and depression , specifically, both brain areas that are responsive to fluctuations in gonadal hormones (McEwen, 2010). Furthermore, reports from the rodent literature highlight that stressors can exacerbate psychopathologies resulting from gonadal hormone dysregulation, regardless of whether this dysregulation results in hormonal deficiencies or excesses (Goel and Bale, 2008;Lagunas et al, 2010;Seney et al, 2012;Wainwright et al, 2011). Additionally, recent evidence confirms that the rodent brain expresses all the molecular mechanisms necessary to synthesize gonadal hormones de novo (Konkle and McCarthy, 2011).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress

Cited by 92 publications

References 83 publications

Preliminary phytochemical analysis and the effect of Agave sisalana on body weight and defensive behaviours in ovariectomized rats

Preliminary phytochemical analysis and the effect of Agave sisalana on body weight and defensive behaviours in ovariectomized rats

Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

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