Long-term patterns of change in ERPs across repeated measurements

Kinoshita, Sayaka; Inoue, M.; Maeda, Hideo; Nakamura, Jun; Morita, Kenichi

doi:10.1016/0031-9384(96)00130-8

Cited by 65 publications

(54 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…P300 ERP application (especially P300 ERP latency) is a well-established neurophysiological approach in any disease where cognitive functions are impaired (20). In addition it has been found to be relatively simple, non-invasive, reproducible and safe to implement as compared with other brain metabolic and structural studies (16,21,22). P300 latency is reported to reflect the duration of the evaluation process for an event or stimulus (23).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

Gölgeli

Tanrıverdi

Süer

et al. 2004

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Impaired cognitive function has been demonstrated in adults with growth hormone (GH) deficiency (GHD) by using different neuropsychological tests. Despite several studies, present knowledge about the impact of GHD and GH replacement therapy (GHRT) on cognitive function is limited. P300 event-related potential (ERP) application is a well-established neurophysiological approach in the assessment of cognitive functions including the updating of working memory content and the speed of stimulus evaluation. GHD is a well-known feature of Sheehan's syndrome and cognitive changes due to GHD and the effects of GHRT remain to be clarified. The present study was designed to investigate the effects of GHD and 6 months of GHRT on cognitive function in patients with Sheehan's syndrome by using P300 latency. Design and methods: The study comprised 14 patients with Sheehan's syndrome (mean age, 49.5^7.8 years) and 10 age-, education-and sex-matched healthy controls. With hormone replacement therapy, basal hormone levels other than GH were stable before enrollment and throughout the GHRT. The diagnosis of GH deficiency was established by insulin-tolerance test (ITT), and mean peak level of GH in response to insulin hypoglycemia was 0.77^0.35 mIU/l. Treatment with GH was started at a dose of 0.45 IU (0.15 mg)/day in month 1, was increased to 0.9 IU (0.30 mg)/day in month 2 and was maintained at 2 IU (0.66 mg)/day. Initially baseline auditory ERPs in patients and controls were recorded at frontal (Fz), central (Cz), and parietal (P3 and P4) electrode sites. In the patient group, ERPs were re-evaluated after 6 months of GH replacement therapy. During each session P300 amplitude and latency were measured. Results: Mean serum insulin-like growth factor-I (IGF-I) concentration in the patient group before GHRT was 23^13 ng/ml. After 6 months of GH therapy mean IGF-I significantly increased to an acceptable level, 234^71 ng/ml (P , 0.05). The mean latencies (at all electrode sites) of the patients before GHRT were found to be significantly prolonged when compared with those of normal controls (P , 0.05). After 6 months of GHRT mean P300 latencies (at all electrode sites) were decreased significantly when compared with latencies before treatment (P , 0.05). Conclusions: The present study, using P300 ERP latencies, therefore suggests an impairment of cognitive abilities due to severe GHD in patients with Sheehan's syndrome and an improvement of cognitive function after 6 months of physiological GHRT. Moreover, this was a novel application of P300 ERP latencies in cognitive function detection in patients with GHD. Further studies with different patient groups need to be done to assess the clinical use of this electrophysiological method in the diagnosis of cognitive dysfunction due to GHD. European Journal of Endocrinology 150 153-159

show abstract

Section: Discussionmentioning

confidence: 99%

“…In the patient group, ERPs were reevaluated after 6 months of GHRT. The reproducibility and reliability of the P300 latency measurements have been clearly established by short-and long-term studies in normal controls after repeated recordings (16,17). On each session P300 amplitude and latency were measured.…”

Section: Gh Administration Protocolmentioning

confidence: 99%

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

Gölgeli

Tanrıverdi

Süer

et al. 2004

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Carrillo-de-la-Pena and Garcia-Larrea 1999; Ivey and Schmidt, 1993;Kinoshita et al, 1996;Lammers and Badia, 1989;Pan et al, 2000;Polich and McIsaac, 1994;Ravden and Polich, 1998;Romero and Polich, 1996), but, however, yielded heterogenous results. If target-P3 amplitude reductions were observed, these could be attributed to several experimental variables, among them the number of target stimuli, length of interblock intervals, and length of intertarget intervals (Carrillo-de-la-Pena and Garcia-Larrea, 1999; Ravden and Polich, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Whereas target-P3 is known to be relatively test-retest reliable (e.g. Kinoshita et al, 1996), little is yet known about the effects of the repeated administration of the novelty-P3 paradigm. Thus, a second aim of the present study was to explore the psychometric characteristics of target-P3 and novelty-P3.…”

Section: Introductionmentioning

confidence: 99%

Auditory novelty oddball allows reliable distinction of top–down and bottom–up processes of attention

Debener

Kranczioch

Herrmann

et al. 2002

International Journal of Psychophysiology

114

View full text Add to dashboard Cite

An auditory novelty-oddball task, which is known to evoke a P3 event-related potential (ERP) in a target condition and a novelty-P3 ERP in response to task-irrelevant unique environmental sounds, was repeatedly applied to healthy participants (ns14) on two separate recording sessions, 7 days apart. Both target-P3 and novelty-P3 were internally consistent and test-retest reliable. Interestingly, novelty-P3 amplitude declined from the first to the second half of each recording session, whereas no systematic alteration between both sessions occurred. The target-P3 showed the opposite pattern, i.e. a reduced amplitude from the first to the second session, but no systematic change within each session. These findings suggest that novelty-P3 amplitude changes reflect habituation, whereas target-P3 session effects may indicate the adjusted amount of processing resources invested into the task. In general, the results support the interpretation of the novelty-P3 as indicating automatic, bottom-up related aspects of attention, whereas the target-P3, in the present paradigm, seems to reflect voluntary, top-down related aspects of attention. ᮊ

show abstract

“…Extremely essential is also the interval between consecutive P300 wave determinations. Experiments intended to determine the effects of repeated P300 wave recording (wave's parameters, and its amplitude in particular) at 7-10 days (or its multiple) interval [29,30] showed a decrease in P300 amplitude already after the second attempt to repeat the recording within 2-4 weeks. The maximum drop was observed during the fourth week of the experiment, and the amplitude returned to its original value during ca.…”

Section: Effects Of Gsm Signals During Exposure To Erps O R I G I N Amentioning

confidence: 99%

Effects of GSM signals during exposure to event related potentials (ERPs)

Bąk¹,

Dudarewicz²,

Zmyślony³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: The primary aim of this work was to assess the effect of electromagnetic field (EMF) from the GSM mobile phone system on human brain function. The assessment was based on the assay of event related potentials (ERPs). Material and Methods:The study group consisted of 15 volunteers, including 7 men and 8 women. The test protocol comprised determination of P300 wave in each volunteer during exposure to the EMF. To eliminate possible effects of the applied test procedure on the final result, the test was repeated without EMF exposure. P300 latency, amplitude, and latency of the N1, N2, P2 waves were analysed. Results: The statistical analysis revealed an effect of EMF on P300 amplitude. In the experiment with EMF exposure, lower P300 amplitudes were observed only at the time in which the volunteers were exposed to EMF; when the exposure was discontinued, the values of the amplitude were the same as those observed before EMF application. No such change was observed when the experiment was repeated with sham exposure, which may be considered as an indirect proof that lower P300 amplitude values were due to EMF exposure. No statistically significant changes were noted in the latencies of the N1, N2, P2 waves that precede the P300 wave, nor in the latency of the P300 itself. Conclusions: The results suggest that exposure to GSM EMF exerts some effects on CNS, including effects on long latency ERPs.

show abstract

Long-term patterns of change in ERPs across repeated measurements

Cited by 65 publications

References 18 publications

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

Auditory novelty oddball allows reliable distinction of top–down and bottom–up processes of attention

Effects of GSM signals during exposure to event related potentials (ERPs)

Contact Info

Product

Resources

About