Long-term persistence of protective immunity in cynomolgus monkeys immunized with a recombinant vaccinia virus expressing the human T cell leukaemia virus type I envelope gene.

Ibuki, Kazuyasu; Funahashi, Saburô; Yamamoto, Hiroshi; Nakamura, Masami; Igarashi, Tatsuhiko; Miura, Tomoyuki; Ido, Eiji; Hayami, Masanori; Shida, Hisatoshi

doi:10.1099/0022-1317-78-1-147

Cited by 39 publications

(33 citation statements)

References 21 publications

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“…31 For HTLV-1, it has been reported that vaccines expressing the envelope protein completely block infection in animal models. 33,34 Among HTLV-1 regulatory and accessory proteins, Tax is known to be the immunodominant protein, and a Tax vaccine was reported to protect against HTLV-1 infection in an animal model. 35 However, because of the high immunogenicity of Tax, its expression is frequently silenced or lost in ATL patients to evade the host immune surveillance.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor

Sugata

Yasunaga

Mitobe

et al. 2015

Blood

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Section: Discussionmentioning

confidence: 99%

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor

Sugata

Yasunaga

Mitobe

et al. 2015

Blood

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“…Monkeys and rabbits have been 4 used to examine HTLV-1 infection, replication, disease manifestations, immune response, and vaccine development [15][16][17][18][19][20]. However, rats and mice are more attractive models for HTLV-1 study because of the ease with which they can be genetically manipulated.…”

Section: Introductionmentioning

confidence: 99%

CRM1, an RNA transporter, is a major species-specific restriction factor of human T cell leukemia virus type 1 (HTLV-1) in rat cells

Zhang

Hakata

Tanaka

et al. 2006

Microbes and Infection

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Rat ortholog of human CRM1 has been found to be responsible for the poor activity of viral Rex protein, which is essential for RNA export of human T cell leukemia virus type 1 (HTLV-1). Here, we examined species-specific barrier of HTLV-1 by establishing rat cell lines, including both adherent and CD4 + T cells, which express human CRM1 at physiological levels. We demonstrated that expression of human CRM1 in rat cells is not harmful to cell growth and is sufficient to restore the synthesis of the viral structural proteins, Gag and Env, at levels similar to those in human cells. Gag precursor proteins were efficiently processed to the mature forms in rat cells and released into the culture medium as sedimentable viralparticles. An HTLV-1 pseudovirus infection system suggested that the released virus particles are fully infectious. Our newly developed reporter cell system revealed that Env proteins produced in rat cells are fully fusogenic, which is the basis for cell-cell HTLV-1 infection.Moreover, we show that the early steps in infection, from post-entry uncoating to integration into the host chromosomes, occur efficiently in rat cells. These results, in conjunction with reports describing efficient entry of HTLV-1 into rat cells, may indicate that HTLV-1 is unique in that its major species-specific barrier is determined by CRM1 at a viral RNA export step.These observations will enable us to construct a transgenic rat model expressing human CRM1 that is sensitive to HTLV-1 infection.

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“…Subsequently, successful passive immunization has been achieved with hyperimmune globulin from healthy donors (Murata et al, 1996;Akari et al, 1997). Successful immunization against HTLV-1 infection has also been accomplished with recombinant vaccinia virus expressing envelope or gag gene products in combination with DNA vaccines (Ibuki et al, 1997;Kazanji et al, 2001). …”

Section: Non-human Primate Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

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Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma Oncogene (2005) 24, 6005-6015.

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Long-term persistence of protective immunity in cynomolgus monkeys immunized with a recombinant vaccinia virus expressing the human T cell leukaemia virus type I envelope gene.

Abstract: To develop effective vaccines against infection with human T cell leukaemia virus type I (HTLV-I), we constructed a recombinant vaccinia virus (WR-SFB5env

Cited by 39 publications

References 21 publications

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor

CRM1, an RNA transporter, is a major species-specific restriction factor of human T cell leukemia virus type 1 (HTLV-1) in rat cells

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

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