Long-term prognosis of asphyxiated full-term neonates with CNS complications

Ishikawa, Tatsuya; Ogawa, Yutaka; Kanayama, Manabu; Wada, Yoshiro

doi:10.1016/s0387-7604(87)80010-4

Cited by 29 publications

(13 citation statements)

References 16 publications

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“…Original articles were selected if they fulfilled the following criteria: (1) initial assessment within the first 12 months of age, (2) follow‐up assessment beyond 1 year of corrected age, (3) description of single neurological items, (4) inclusion of infants at risk for developmental disorders, and (5) publication in English. Twenty articles fulfilled the criteria . An additional three articles were discovered by checking the reference lists of articles of interest (original articles and reviews) …”

Section: Methodsmentioning

confidence: 99%

Prognostic significance of neurological signs in high‐risk infants – a systematic review

Hamer

Hadders‐Algra

2016

Develop Med Child Neuro

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The aim of this paper was to systematically review the literature on the significance of specific neurological signs in infancy, in particular in infants at risk for developmental problems such as cerebral palsy (CP). A literature search was performed using the databases PubMed, Embase, Web of Science, and AMED. Papers on infantile reactions (‘primitive reflexes’) and postural reactions were included if data were available allowing for calculation of sensitivity, specificity, or positive and negative predictive value for CP or atypical developmental outcome. Our search identified 23 articles on 20 different neurological signs. Properties of six neurological signs were reported in at least three different papers. The data indicated that, in early infancy, an absent Moro or plantar grasp response may be predictive for adverse developmental outcome. After early infancy, persistence of the Moro response and asymmetric tonic neck reflex was clinically significant. Prediction of a delayed emergence of the parachute reaction increases with age. Abnormal performances on the pull‐to‐sit manoeuvre and vertical suspension test have predictive significance throughout infancy. The neurological signs reviewed have some predictive value in infants at risk. For most of the signs, criteria for abnormality and significance are age‐dependent.

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Section: Methodsmentioning

confidence: 99%

Prognostic significance of neurological signs in high‐risk infants – a systematic review

Hamer

Hadders‐Algra

2016

Develop Med Child Neuro

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“…The absence of the response during the neonatal period and early infancy is of especial clinical significance and may indicate a compromised condition or disorder including birth injury, severe birth asphyxia, intracranial hemorrhage, infection, brain malformation, general muscular weakness of any cause, and CP of the spastic type [10, 31, 69, 76, 77]. On the other hand, a hyperactive response of the reflex is a common feature of neonatal withdrawal from maternal drug abuse including volatile substances, heroin, and opioids [78–80].…”

Section: The Moro Reflexmentioning

confidence: 99%

The Grasp Reflex and Moro Reflex in Infants: Hierarchy of Primitive Reflex Responses

Futagi

Toribe

Suzuki

2012

International Journal of Pediatrics

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The plantar grasp reflex is of great clinical significance, especially in terms of the detection of spasticity. The palmar grasp reflex also has diagnostic significance. This grasp reflex of the hands and feet is mediated by a spinal reflex mechanism, which appears to be under the regulatory control of nonprimary motor areas through the spinal interneurons. This reflex in human infants can be regarded as a rudiment of phylogenetic function. The absence of the Moro reflex during the neonatal period and early infancy is highly diagnostic, indicating a variety of compromised conditions. The center of the reflex is probably in the lower region of the pons to the medulla. The phylogenetic meaning of the reflex remains unclear. However, the hierarchical interrelation among these primitive reflexes seems to be essential for the arboreal life of monkey newborns, and the possible role of the Moro reflex in these newborns was discussed in relation to the interrelationship.

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“…It has also been demonstrated that the presence of an abnormal neurologic examination in the neonatal period (not necessarily referred to as hypoxic-ischemic encephalopathy), particularly if this examination persisted, was a good indicator of a poorer prognosis. 1,11,55,131,140,148 Neonatal seizures enhanced the risk for later disability, particularly if presenting early (<24 hours) and if intractable. Overall, studies using hypoxic-ischemic encephalopathy as a grading system indicated that asphyxiated neonates presenting with grade 1 hypoxic-ischemic encephalopathy (mild) had no major sequelae, whereas those with grade 2 encephalopathy (moderate) carried approximately a 30 to 60% chance of major deficits and those with a stage 3 hypoxic-ischemic encephalopathy (severe) over a 90% incidence of disability or death.…”

Section: Studies Using Hypoxic-ischemic Encephalopathy/ Neonatal Encementioning

confidence: 99%

Topical Review: Long-Term Developmental Outcome of Asphyxiated Term Neonates

2001

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Asphyxia remains one of the main causes of later disability in term infants. Despite many publications identifying possible predictors of outcome in this population of interest, little is known of the long-term developmental outcome of asphyxiated term neonates. Observational studies have largely focused on short-term outcomes, with an emphasis on significant neurologic sequelae and intellectual impairments. This article reviews the literature that has described the developmental outcome of asphyxiated term newborns. As part of this review, we have also highlighted the evolution of the definition of asphyxia and delineated appropriate markers that should be used in future research on this population.

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Long-term prognosis of asphyxiated full-term neonates with CNS complications

Cited by 29 publications

References 16 publications

Prognostic significance of neurological signs in high‐risk infants – a systematic review

Prognostic significance of neurological signs in high‐risk infants – a systematic review

The Grasp Reflex and Moro Reflex in Infants: Hierarchy of Primitive Reflex Responses

Topical Review: Long-Term Developmental Outcome of Asphyxiated Term Neonates

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