Long-term prognostic implications of hemodynamic and plaque assessment using coronary CT angiography

Coronary Physiology-Based Approaches for Plaque Vulnerability: Implications for Risk Prediction and Treatment Strategies

“… 73) In a recent report from the first-in-human study of CCTA-derived FFR, the predictability for per-lesion and vessel 10-year outcomes was highest when plaque and hemodynamic predictors were added to baseline clinical and lesion characteristics, suggesting that physiological and plaque components may contribute synergistically even very long-term coronary events. 74) …”

“…Several studies have demonstrated that ΔFFR may have additive predictive values for plaque vulnerability and clinical outcomes to FFR. 53) 57) 74) The strength of ΔFFR is its simplicity in that ΔFFR can be obtained using well-defined FFR pullback estimation without additional analysis tools. The prognostic value of ΔFFR or ΔNHPR will be demonstrated further in ongoing studies, such as the Prognostic Impact of Lesion-specific Hemodynamic Index in Patients With Coronary Artery Disease (PRIME-FFR) study (NCT05250557) and the Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting (DEFINE GPS) study (NCT04451044).…”

Diagnostic Performance of On-Site Automatic Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve

“… 3) 6) With the advancement of technology, FFR can be noninvasively computed from CCTA and numerous studies have demonstrated a good correlation between invasive FFR and CCTA-derived FFR (CT-FFR) and its incremental information on practical decision-making. 7) 8) 9) 10) 11) 12) 13) 14) However, previous methods need the transfer of CCTA data to external facilities, supercomputing, and waiting times for processing. Several algorithms have been developed to mitigate these limitations and enable these processes on-site.…”