Long‐Term Prognostic Value of Baseline C‐Reactive Protein in Predicting Recurrence of Atrial Fibrillation after Electrical Cardioversion

Korantzopoulos, Panagiotis; Kalantzi, Kallirroi; Siogas, Konstantinos; Goudevenos, John

doi:10.1111/j.1540-8159.2008.01177.x

Cited by 20 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this report, we sought to determine whether plasma apelin levels measured before external electrical cardioversion may predict recurrence of arrhythmia in patients treated with antiarrhythmic drugs. Together with apelin, we also studied the prognostic role of markers of inflammation and neurohormonal activation such as brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP), which have been previously associated with recurrence of arrhythmia in patients with persistent AF (17)(18)(19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

Apelin Plasma Levels Predict Arrhythmia Recurrence in Patients with Persistent Atrial Fibrillation

Falcone

Buzzi

D’Angelo

et al. 2010

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Low levels of the regulatory peptide apelin have been reported in patients with lone atrial fibrillation (AF). We evaluate the potential utility of assessing apelin plasma levels as a predictor of AF recurrence in individuals presenting for electrical cardioversion. Plasma levels of apelin, brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein were measured in 93 patients, with persistent AF before successful external electrical cardioversion. Significantly lower apelin plasma levels were found in patients with AF recurrence as respect to population with persistence of sinus rhythm during a six months follow-up. The hazard increased with duration of AF, left atrial dimension, BNP concentrations. Subjects with apelin levels below the median had a hazard ratio of 3.1 of arrhythmia recurrence with respect to those with high apelin levels (p< 0.05). A significant difference in BNP levels was found between patients with and without AF recurrence during the follow-up. After adjusting for potential confounders, both BNP and apelin retained their statistical significance as independent predictors of arrhythmia recurrence. Patients with both low apelin and elevated BNP had a worse prognosis compared with those with either low apelin or elevated BNP alone. Low plasma apelin levels before external electrical cardioversion are an independent prognostic factor for arrhythmia recurrence in patients with AF treated with antiarrhythmic drugs. Apelin may be of particular value for the identification of high-risk patients in addition to BNP.

show abstract

mentioning

confidence: 99%

Apelin Plasma Levels Predict Arrhythmia Recurrence in Patients with Persistent Atrial Fibrillation

Falcone

Buzzi

D’Angelo

et al. 2010

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

show abstract

“…34 more were subsequently excluded as they did not meet the inclusion criteria and the remaining 11 were selected for systematic review. [10][11][12][13][14][15][16][17][18][19][20] The concise detail of these studies is shown in [ Table 1]. Of these, only 8 studies in which absolute numbers (of subjects at risk for AF and subjects with AF) for a CRP cut off of around 3 mg/l could be obtained were included in the final meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Three of the studies selected for review were not included in the final meta-analyses as the cut off CRP used was quite dissimilar. 14,16,20 The studies by Korantzopoulos et al 20 and Kotsakaou et al 14 used CRP cutoffs of 4.3 and 4.9 mg/l respectively. Secondary analysis using the data from these studies and that from Dernellis et al, 12 where numbers for a similar CRP cut off (4.85 mg/l) were available, yielded a relative risk of 4.03 (3.1, 5.25) for AF [ Figure 4].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

C-Reactive Protein and the risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Alla¹,

Thambidorai²,

Anand³

et al. 2010

J.A.F.I.B

View full text Add to dashboard Cite

There is increasing evidence linking C-reactive protein (CRP) and atrial fibrillation (AF). Despite the abundance of literature, confusion exists regarding this association because of inconsistent results. MEDLINE and Cochrane Controlled Trials Register databases were carefully searched through July, 2009 combining the following terms "C-reactive protein" and "atrial fibrillation". Reference lists of selected articles and reviews were also screened to identify additional relevant studies. Of the 129 studies initially identified, 8 studies with 7507 subjects (719 with AF) were included in the meta-analysis. Analysis yielded a relative risk of 1.63 (1.43, 1.86) for occurrence of AF when CRP level was above a cut off of 3-3.5 mg/l. When 3 studies with data on a higher cut off of 4.5-5.0 mg/l were analyzed separately, the relative risk was 4.03 (3.1, 5.25). Our study suggests that elevated CRP is associated with increased risk for AF. The risk appears incremental with higher CRP levels conferring proportionately increased risk. There is an urgent need for further large scale, well designed prospective studies to assess the relationship between CRP and AF.

show abstract

“…The highsensitivity CRP level is correlated with the incidence (31,32), defibrillation efficacy (33), recurrence (34) and prognosis of AF (35). Recurrent acid reflux also induces low-grade persistent inflammation and the secretion of cytokines, such as IL1β and IL6 (36).…”

Section: Mechanisms Underlying the Development Of Gerdrelated Afmentioning

confidence: 99%

Further Assessment of Atrial Fibrillation as a Risk Factor for Gastroesophageal Reflux Disease: A Multicenter Questionnaire Survey

et al. 2013

View full text Add to dashboard Cite

Objective Although both atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are common diseases, the relationship between these two conditions remains controversial, depending on the study design and type of AF. Therefore, we focused on the relationship between nonvalvular AF and GERD. Methods A total of 479 consecutive subjects (255 men and 224 women, mean age: 60.4 ± 12.8 years), including outpatients at several hospitals (n=201) and participants of an annual health screening program (n= 278), were enrolled. Subjects with valvular AF, malignancy or dementia were excluded. The frequency scale for symptoms of GERD (F-scale) was applied after obtaining each patient's informed consent for screening symptomatic GERD with a total cutoff score of 8 points. The score on the questionnaire was correlated with the baseline characteristics extracted from the patients' medical records. Results The total F-scale scores were significantly higher in the older patients (! 60 years) than in the younger patients (<60 years) (p=0.017) and increased in the following order: permanent AF > paroxysmal AF > sinus rhythm (p=0.003). The incidence of GERD increased in the same order among the patients with the various heart rhythm classifications (p<0.001). Coronary heart disease, hypertension, diabetes and dyslipidemia were not correlated with the F-scale scores or incidence of GERD. The stepwise discriminant analyses demonstrated that nonvalvular AF alone was significantly associated with symptomatic GERD (Wilks' lambda=0.983, p=0.004). Conclusion This multicenter study demonstrated that nonvalvular AF is significantly correlated with symptomatic GERD. This small sample survey warrants a future study of a large-scale cohort.

show abstract

Long‐Term Prognostic Value of Baseline C‐Reactive Protein in Predicting Recurrence of Atrial Fibrillation after Electrical Cardioversion

Abstract: Our findings suggest that baseline CRP levels before EC have an independent prognostic value in predicting the long-term risk of AF recurrence.

Cited by 20 publications

References 19 publications

Apelin Plasma Levels Predict Arrhythmia Recurrence in Patients with Persistent Atrial Fibrillation

Apelin Plasma Levels Predict Arrhythmia Recurrence in Patients with Persistent Atrial Fibrillation

C-Reactive Protein and the risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Further Assessment of Atrial Fibrillation as a Risk Factor for Gastroesophageal Reflux Disease: A Multicenter Questionnaire Survey

Contact Info

Product

Resources

About