Abstract. Milionis HJ, Kalantzi KJ, Goudevenos JA, Seferiadis K, Mikhailidis DP, Elisaf MS (University of Ioannina and University Hospital of Ioannina, Ioannina; Greece; and Royal Free Hospital, London, UK). Serum uric acid levels and risk for acute ischaemic nonembolic stroke in elderly subjects. J Intern Med 2005; 258: 435-441.Background. Elevated serum uric acid (SUA) levels have been proposed as an independent risk factor for cardiovascular (CV) morbidity and mortality. Recent evidence suggests that treatments with a hypouricaemic action have a favourable effect on CV event prevention. Objectives. The association between SUA and acute ischaemic/nonembolic stroke was assessed in a population-based case-control study in the prefecture of Ioannina, Epirus, Greece. Subjects and methods. A total of 163 patients aged older than 70 years (88 men and 75 women) admitted due to a first-ever-in-a-lifetime acute ischaemic/nonembolic stroke and 166 volunteers (87 men and 79 women) without a history of CV disease were included. The association between SUA and stroke was determined by multivariate logistic regression modelling after adjusting for potential confounding factors.

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The metabolic syndrome is highly associated with acute coronary syndrome in patients younger than 45 years of age, indicating the need for early and intensive preventive measures.

Our findings suggest that baseline CRP levels before EC have an independent prognostic value in predicting the long-term risk of AF recurrence.