2022
DOI: 10.3389/fendo.2022.968239
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Long-term remission of type 2 diabetes after very-low-calorie restriction and related predictors

Abstract: PurposeVery low-calorie restriction (VLCR) can induce remission of type 2 diabetes mellitus (T2DM), but its long-term remission and related predictors have not been clarified. The aim of present study is to investigate the effect of VLCR in inducing long-term T2DM remission, and the underlying predictors.MethodsA total of 61 participants with T2DM who received 9 days of VLCR from Dec 2012 to Oct 2020 were followed up in Nov 2021, and divided into responders and non-responders groups. Responders were defined as… Show more

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Cited by 13 publications
(14 citation statements)
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“…Diabetes remission was achieved by 61% of the intervention group in comparison to only 12% in the control group [ 32 ]. A study by Wei et al—investigating the effects of a VLCR diet on individuals with T2DM—found similar results [ 29 ]. In the study, 39% of participants achieved long-term T2DM remission with a median duration of 7.8 years following the VLCR intervention.…”
Section: Resultsmentioning
confidence: 59%
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“…Diabetes remission was achieved by 61% of the intervention group in comparison to only 12% in the control group [ 32 ]. A study by Wei et al—investigating the effects of a VLCR diet on individuals with T2DM—found similar results [ 29 ]. In the study, 39% of participants achieved long-term T2DM remission with a median duration of 7.8 years following the VLCR intervention.…”
Section: Resultsmentioning
confidence: 59%
“…In the study, 39% of participants achieved long-term T2DM remission with a median duration of 7.8 years following the VLCR intervention. These findings highlight the potential of VLCR in the long term in achieving remission [ 29 ].…”
Section: Resultsmentioning
confidence: 86%
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“…2 Rather than viewing T2DM as a progressive condition and focusing on upward titration of medication, the management of T2DM has now shifted towards reversing its progression. 3 Many current T2DM management guidelines recommend lifestyle modification as part of first-line therapy for the management of hyperglycaemia in individuals with recently diagnosed T2DM. 4,5 Lifestyle changes through diet and physical activity with the goal to achieve and maintain ≥5% weight loss is often recommended for individuals with both T2DM and overweight or obesity.…”
Section: Introductionmentioning
confidence: 99%