Long-term results of breast cancer irradiation treatment with low-dose-rate external irradiation

Reirradiation of Large-Volume Recurrent Glioma With Pulsed Reduced-Dose-Rate Radiotherapy

“…A reduced dose rate can be obtained by using continuous reduced-dose-rate aging 60 Co sources, which are not readily available clinically, or by dividing a standard treatment fraction into a number of equal subfractions delivered in a pulsed manner separated by a fixed interval (5). Early clinical studies investigating fractionated reduced-dose-rate external beam RT in the curative setting have demonstrated an improved therapeutic ratio in oropharynx cancer (6) and breast cancer (7,8).…”

Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region

“…A reduced dose-rate can be obtained by dividing a standard treatment fraction into a number of equal sub-fractions that are delivered in a pulsed manner separated by a fixed time interval, thus allowing for repair during each sub-fraction [5]. Early clinical studies investigating fractionated reduced dose-rate external beam RT in the curative setting have demonstrated an improved therapeutic ratio in oropharynx cancer [6,7] and breast cancer [8,9].…”

External beam pulsed low dose radiotherapy using volumetric modulated arc therapy: Planning and delivery

“…7 The concept of low dose radiotherapy is not new, and has been examined for head and neck and breast cancer using cobalt-60 teletherapy machines by Perquin and colleagues. [11][12][13] The same concept, utilizing low dose treatments for the treatment of recurrent glioma was recently reported in a phase I/II study. 14 These studies emphasized that the clinical efficacy of low dose radiotherapy is due to low dose rate delivery, and not low dose or pulse treatments per se.…”