Long-term results of chemoradiotherapy for locally advanced esophageal cancer, using daily low-dose 5-fluorouracil and cis-diammine-dichloro-platinum (CDDP)

Abstract

Given the large proportion of patients in this study with inoperable disease (roughly three quarters), our treatment seemed to provide equivalent efficacy and less hematological toxicity than standard-dose chemoradiotherapy.

Chemoradiotherapy for T4 and/or M1 lymph node esophageal cancer: experience since 2000 at a high-volume center in Japan

“…Although Higuchi et al reported remarkably good results [8], findings from other institutions have remained unchanged [9][10][11][12][13] (Table 4). …”

Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: the Japanese Radiation Oncology Study Group (JROSG) Survey

“…The type of chemotherapy differed significantly among the institutions. In Japan, low-dose protracted infusion chemotherapy combined with full-dose RT of 60-66 Gy used to be a popular regimen for locally advanced esophageal squamous cell carcinomas [5,7,16,20,22]. In the present analysis, full-dose FP was used most frequently (42.5%), followed by low-dose FP (36.8%) ( Table 2).…”

“…Various chemotherapy regimens of full-dose FP were included: (1) two cycles of cisplatin 70-80 mg/m 2 (day 1) and 5-FU 700-800 mg/m 2 /day administered as continuous intravenous infusion (IV) (days 1-4 or 1-5) [18][19][20], (2) two cycles of cisplatin 40 mg/m 2 (days 1 and 8) and 5-FU 400 mg/m 2 /day as continuous IV (days 1-5 and 8-12) [6,10], and (3) two or three cycles of cisplatin 60 mg/m 2 (day 1) and 5-FU 400 mg/m 2 /day as continuous IV (days 1-4) [9,21]. Low-dose FP included the following regimens: (1) two cycles of cisplatin 7 mg/m 2 (days 1-5 and 8-12) and 5-FU 250 mg/m 2 /day as continuous IV (days 1-14) [5,18,19], and (2) six weekly cycles of cisplatin 3-5 mg/m 2 (days 1-5) and 5-FU 180-250 mg/m 2 as continuous IV (days 1-5 or 1-7) [19,20,22]. The other regimens included: (1) two cycles of cis-diammine-glycolatoplatinum (Nedaplatin) 55-80 mg/m 2 and 5-FU 300-700 mg/m 2 as continuous IV (days 1-5) [23], and (2) daily administration of 5-FU 300 mg/m 2 /day as continuous IV for 6 weeks [7].…”

Elevation of serum carcinoembryonic antigen level in a patient with hypothyroidism after radiation therapy for cervical esophageal cancer

“…In the booster treatment of 26 Gy, those doses were 21.3, 31.6, and 29.1 Gy, respectively. Chemotherapy consisted of 24-h continuous infusion of 250 mg/m 2 5-fluorouracil and 1-h bolus infusion of 3 mg/m 2 cis-diammine-dichloro-platinum on days when radiotherapy was given, as previously reported [5].…”