Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

Lacava, L.M.; Garcia, Velia; Kückelhaus, Selma Aparecida Souza; Azevedo, Ricardo Bentes; Sadeghiani, N.; Buske, N.; Morais, P.C.; Lacava, Z.G.M.

doi:10.1016/j.jmmm.2003.12.852

Cited by 60 publications

(52 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to slow clearance and a tendency to agglomerate, 159 dextran coated NPs have also been shown to induce differentiation of monocytes into macrophages. 55 …”

Section: Biodistribution-relation To Nanoparticle Size and Stabilitymentioning

confidence: 99%

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

2011

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (NPs) are used in a rapidly expanding number of research and practical applications in the biomedical field, including magnetic cell labeling separation and tracking, for therapeutic purposes in hyperthermia and drug delivery, and for diagnostic purposes, e.g., as contrast agents for magnetic resonance imaging. These applications require good NP stability at physiological conditions, close control over NP size and controlled surface presentation of functionalities. This review is focused on different aspects of the stability of superparamagnetic iron oxide NPs, from its practical definition to its implementation by molecular design of the dispersant shell around the iron oxide core and further on to its influence on the magnetic properties of the superparamagnetic iron oxide NPs. Special attention is given to the selection of molecular anchors for the dispersant shell, because of their importance to ensure colloidal and functional stability of sterically stabilized superparamagnetic iron oxide NPs. We further detail how dispersants have been optimized to gain close control over iron oxide NP stability, size and functionalities by independently considering the influences of anchors and the attached sterically repulsive polymer brushes. A critical evaluation of different strategies to stabilize and functionalize core-shell superparamagnetic iron oxide NPs as well as a brief introduction to characterization methods to compare those strategies is given.

show abstract

“…In addition to slow clearance and a tendency to agglomerate, 159 dextran coated NPs have also been shown to induce differentiation of monocytes into macrophages. 55 …”

Section: Biodistribution-relation To Nanoparticle Size and Stabilitymentioning

confidence: 99%

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

2011

View full text Add to dashboard Cite

show abstract

“…For instance, it has been shown that iron oxide nanoparticles remain in an organism for several days 56 or even up to 6 months. 57 aMF-cells interaction Figure 5 shows MTT results when an AMF was applied to colon cancer cells using the MTT assay. When the AMF was applied for 10 minutes, the viability did not change with both field frequencies.…”

Section: Magnetic Nws-cells Interactionmentioning

confidence: 99%

Non-chemotoxic induction of cancer cell death using magnetic nanowires

Contreras¹,

Sougrat²,

Zaher³

et al. 2015

IJN

102

View full text Add to dashboard Cite

In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods.

show abstract

“…The coating of long chain polymer molecules and/or other surfactants on ferrite particles serves as protective layer on the nanoparticles and minimizes the direct exposure of the ferrite surface to the biological environment. Several surfactant and polymer (citrate, polyaspertic acid, dextran) coated Fe 3 O 4 -based magnetic fluids have been tested for biocompatibility [10][11][12]. There is a need for development of water-based biocompatible ferrofluids of Fe 1Àx B x Fe 2 O 4 (B ¼ Mn, Co) particle.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] for biomedical applications

Giri

Pradhan

Somani

et al. 2008

Journal of Magnetism and Magnetic Materials

114

View full text Add to dashboard Cite

Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

Cited by 60 publications

References 5 publications

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

Stabilization and functionalization of iron oxide nanoparticles for biomedical applications

Non-chemotoxic induction of cancer cell death using magnetic nanowires

Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] for biomedical applications

Contact Info

Product

Resources

About