Magnetic resonance was used to investigate the kinetic disposition of magnetite nanoparticles (9.4 nm core diameter) from the blood circulation after intravenous injection of magnetite-based dextran-coated magnetic fluid in female Swiss mice. In the first 60 min the time-decay of the nanoparticle concentration in the blood circulation follows the one-exponential (one-compartment) model with a half-life of (6.9 +/- 0.7) min. The X-band spectra show a broad single line at g approximately 2, typical of nanomagnetic particles suspended in a nonmagnetic matrix. The resonance field shifts toward higher values as the particle concentration reduces, following two distinct regimes. At the higher concentration regime (above 10(14) cm(-3)) the particle-particle interaction responds for the nonlinear behavior, while at the lower concentration regime (below 10(14) cm(-3)) the particle-particle interaction is ruled out and the system recovers the linearity due to the demagnetizing field effect alone.

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The static magnetic birefringence (SMB) of nickel-ferrite ionic magnetic fluid was investigated within the oscillating dipole-interaction anisotropy concept proposed by Xu and Ridler [J. Appl. Phys. 82, 326 (1997)]. The model was extended to include the magnetic texture of particle agglomerates and the field dependence of the magnetic permeability. The SMB data of samples subjected or not to a magnetic aging process and presenting particle concentration in the range of 2×1016 to 8×1016 particle/cm3 were successfully described. The particle size distribution obtained from the fit of the SMB data was discussed in comparison with the data obtained from transmission electron microscopy.

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Magnetic resonance is used to investigate biodistribution aspects of dextran-coated magnetite nanoparticles (9.4 nm core diameter) in both liver and spleen from 5 minutes up to 6 months after intravenous administration of a magnetic fluid sample in female Swiss mice. Using magnetic resonance data important parameters such as the absorption half-life (t 1/2 = 12 ± 2 min in the liver and t 1/2 = 11 ± 2 min in the spleen), the peak time (1.7 ± 0.2 h in the liver and 1.9 ± 0.2 h in the spleen), and the disposition half-life of the dextran-coated magnetite nanoparticles in mice organs (t 1/2 = 70 ± 10 h in the liver and t 1/2 = 32 ± 7 h in the spleen) were assessed. In addition, light and electron microscopy showed several aspects that may be related to the iron metabolism. Microscopic analysis also revealed that although magnetite nanoparticles or iron released from them are retained in the organism for a long period of time, no morphologic alteration is induced by the intravenous administration of the magnetic fluid sample, evidencing its biocompatibility. The used tests may represent an adequate methodology for nanotoxicology evaluation.