Long-term safety follow-up of an anterior chamber angle-supported phakic intraocular lens

Kohnen, Thomas; LaFontaine, Laura; Andrew, Russell; Demong, Thaddeus; Rabinovitch, Theodore; Pop, Mihai; Roy, Francis; Holland, Simon; Schweitzer, Cédric; Cochener, Béatrice; Malecaze, François; Schmickler, Stefani; Knorz, Michael C.; Bellucci, Roberto; Gomes, Miguel; Alió, Jorge L.; Kloess, Price M.; Maxwell, Andrew J.; Salz, James J.; Foster, Gary; Kraff, Colman R.; Stahl, Jason; Holland, Edward J.; Grosinger, Les D.; Pepose, Jay S.; Lane, Stephen S.; Wong, Margaret Wan Nar; Schultze, R.; Dupps, William J.; Nutaitis, Matthew J.; Thompson, Vance; Horn, Jeffrey; Whitsett, Jeffrey C; Hu, Jerry; Lehmann, Robert; Vukich, John

doi:10.1016/j.jcrs.2017.06.035

Cited by 22 publications

(19 citation statements)

References 15 publications

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“…Although several phakic IOL models have been withdrawn from the market, the problem was never the failure to achieve refractive success or a satisfactory UDVA, but were complications due to the phakic IOL implantation (3,18).…”

Section: Discussionmentioning

confidence: 99%

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Refractive Results and Endothelial Cell Density After Eyecryl Phakic Intraocular Lens Implantation

Ürdem¹

2019

Beyoglu Eye J

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This study was an examination of the refractive results and complications encountered with implantation of the Eyecryl phakic intraocular lens (IOL) (Biotech Vision Care, Luzern, Switzerland). Methods: IOL recipients with a follow-up period of at least 2 years were included the study. Uncorrected and corrected distance visual acuity (UDVA and CDVA, respectively), central endothelial cell density (ECD), and procedure-related complication data were recorded. Results: The study included 52 eyes from 26 patients. The efficacy index (postoperative UDVA/preoperative CDVA) was 1.32±1.09 in the first year and 1.39±1.03 in the second year. The safety index (postoperative CDVA/preoperative CDVA) was 1.69±1.16 at the last follow-up. None of the patients lost 2 or more lines of CDVA. The mean ECD loss was-4.51±9.69% at 1 year (p=0.005). There was no statistically significant ECD loss between the 1-and 2-year follow-up visits (p=0.794). Conclusion: The results of Eyecryl phakic IOL implantation were favorable in terms of efficacy and safety.

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Section: Discussionmentioning

confidence: 99%

“…Despite satisfactory refractive results, many angle-supported phakic IOLs have been removed from the market due to late complications (1)(2)(3). On the other hand, several studies have reported positive results with regard to the efficacy and safety of iris-claw and posterior chamber phakic IOLs (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Refractive Results and Endothelial Cell Density After Eyecryl Phakic Intraocular Lens Implantation

Ürdem¹

2019

Beyoglu Eye J

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“…e AAO Task Force guidelines recommend that the percentage of eyes with a total ECD loss ≥25% after 3 years be used as an endpoint of investigation criterion. However, the AAO did not provide the long-term destiny prediction of AC-IOLs, considering that the data on long-term changes and safety (more than 10 years) of corneal endothelial cells were still urgently limited [3,5,8,9]. Hence, in this study, we conducted a retrospective nonrandomized study of angle-supported and iris-fixated IOLs with a mean follow-up time of over 12 years.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Destiny of Corneal Endothelial Cells in Anterior Chamber Intraocular Lens-Implanted Eyes

Zhu

Chen

et al. 2020

Journal of Ophthalmology

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Purpose. To investigate the long-term changes of corneal endothelial cells (EC) in anterior chamber intraocular lens- (AC-IOL-) implanted eyes. Methods. Retrospective study. We included 37 eyes (25 patients) that received AC-IOL implantation previously in the Eye and ENT Hospital of Fudan University between 1995 and 2016. Follow-up outcomes included the best-corrected visual acuity (BCVA), endothelial cell density, hexagonality, coefficient of variance, and central corneal thickness. Results. In total, 23 eyes (62.16%) with phakic and 14 eyes (37.84%) with aphakic AC-IOLs were included. Among these, 3 eyes (8.11%) were angle-supported AC-IOLs and 34 eyes (91.89%) were Artisan iris-fixated AC-IOLs. The mean age of patients was 41.40 ± 17.17 years, and the mean follow-up time was 12.12 ± 4.71 years in our study. At the follow-up time, corneal decompensation existed in 3 angle-supported AC-IOL eyes with a rate of 100% and 15 iris-fixated AC-IOL eyes with a rate of 44.12%. AC-IOL displacement occurred in 14 (41.18%) iris-fixated AC-IOL eyes. In the 19 iris-fixated AC-IOL eyes without corneal decompensation, significant changes also took place in corneal endothelial cells. The endothelial cell density decreased from 2843.26 ± 300.76 to 2015.58 ± 567.99 cells/mm2 (29.1% loss, P < 0.001 ) and hexagonality decreased from 51.21 ± 7.83 to 42.53 ± 9.17 (%) (16.9% loss, P < 0.001 ). The Kaplan–Meier survival curve also demonstrated the accumulated expectation rates of corneal endothelial cell decomposition for AC-IOLs with a median survival time of 12 years. Conclusion. We reported a significant chronic loss and long-term decompensation destiny of corneal endothelial cells in AC-IOL eyes. Semiannual or annual follow-up and evaluation of endothelial cells should be conducted in AC-IOL-implanted patients.

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“…16 Significant ECL represents the second most frequent indication for pIOL explant, only surpassed by cataract development. 2,3,11,13 To date, there is no determined consensus regarding best visual rehabilitation strategy in patients with severe endothelial cell loss as a complication of a pIOL implant, mainly due to lack of data on literature. To the best of our knowledge, this study represents the largest cohort reported so far, being the first revealing long-term (⩾3 years) visual and anatomic outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Phakic intraocular lenses (pIOLs) are a long-term accurate and safe methodology to correct myopia or myopic astigmatism beyond the range of laser refractive procedures. [1][2][3][4][5] Fulfilling the adequate inclusion criteria, they are an excellent option for experienced surgeons. Furthermore, complications rate with today's used pIOLs is significantly lower than with historical models.…”

Section: Introductionmentioning

confidence: 99%

Long-term results of Descemet-stripping automated endothelial keratoplasty for endothelial failure caused by phakic intraocular lenses

Hipólito-Fernandes

Elisa-Luís

Vieira

et al. 2020

European Journal of Ophthalmology

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Purpose: To describe the surgical approach and long-term outcomes of Descemet-stripping automated endothelial keratoplasty (DSAEK) for endothelial failure secondary to phakic intraocular lenses (pIOL). Methods: Retrospective, interventional case series of 18 eyes of 13 patients who developed endothelial failure secondary to pIOL implant. Patients were submitted to pIOL explant and DSAEK for visual rehabilitation, with or without phacoemulsification plus posterior-chamber intraocular lens implant. The minimum follow-up time was 3 years and the main outcome measures were best-corrected visual acuity (BCVA), endothelial cell density (ECD) and percentage of endothelial cell loss (ECL), intraoperative and postoperative complications. Results: Patients’ mean age was 47.44 (7.86) years with a mean follow-up time of 55.61 (14.13) months. Sixteen eyes (88.9%) had an angle-supported pIOL. The mean pIOL implant-to explant time was 8.17 (2.73) years. BCVA improved from 1.00 (0.36) logMAR preoperatively to 0.29 (0.36) logMAR at 1 year of follow-up ( p < 0.001), remaining stable over the entire follow-up period ( p > 0.05). At the last visit, all corneas were clear, with a mean ECD of 724.74 (325.57) cells/mm2. During the follow-up, two eyes (11.1%) required a re-DSAEK due to early graft failure (<3 months). Conclusion: Our outcomes reveal that an individualized and careful approach may result in a stable visual rehabilitation in young patients with corneal decompensation following pIOL implant.

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Long-term safety follow-up of an anterior chamber angle-supported phakic intraocular lens

Cited by 22 publications

References 15 publications

Refractive Results and Endothelial Cell Density After Eyecryl Phakic Intraocular Lens Implantation

Refractive Results and Endothelial Cell Density After Eyecryl Phakic Intraocular Lens Implantation

Long-Term Destiny of Corneal Endothelial Cells in Anterior Chamber Intraocular Lens-Implanted Eyes

Long-term results of Descemet-stripping automated endothelial keratoplasty for endothelial failure caused by phakic intraocular lenses

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