Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma

Römer, C; Daeppen, M.A. Broglie; Mueller, M.R.; Huber, Gerhard; Guesewell, S.; Stoeckli, Sandro J.

doi:10.1016/j.oraloncology.2018.12.027

Cited by 21 publications

(29 citation statements)

References 30 publications

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“…We think that a more prolonged period enhances the healing and recovery of a surgical site, in addition to allowing adequate time for psychological adaption. The finding of worsened swallowing symptoms during the first month after oral reconstruction is in accordance with the finding of Dwivedi et al 20 Romer et al 21 reported a similar result.…”

Section: Discussionsupporting

confidence: 91%

<p>Short-Term Quality of Life, Functional Status, and Their Predictors in Tongue Cancer Patients After Anterolateral Thigh Free Flap Reconstruction: A Single-Center, Prospective, Comparative Study</p>

Tamer¹,

Chen²,

Xu³

et al. 2020

CMAR

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Section: Discussionsupporting

confidence: 91%

<p>Short-Term Quality of Life, Functional Status, and Their Predictors in Tongue Cancer Patients After Anterolateral Thigh Free Flap Reconstruction: A Single-Center, Prospective, Comparative Study</p>

Tamer¹,

Chen²,

Xu³

et al. 2020

CMAR

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“…Moreover, there are many detrimental side effects caused by chemotherapy and radiotherapy, including xerostomia, loss of taste, mucositis, dermatitis, osteoradionecrosis, peripheral neuropathy and nephrotoxicity etc. (Romer et al, 2019;Bashir et al, 2020), which greatly affect the life quality of the patients. Therefore, there is a pressing need to find more anticancer drugs or therapies which are more efficient but with less side effects for oral cancer.…”

Section: Introductionmentioning

confidence: 99%

PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells

Luo

Gan

et al. 2021

Front. Cell Dev. Biol.

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The anticancer properties of erianin have been recently discovered. However, the antitumor effect of erianin in oral squamous cell carcinoma (OSCC) remains unclear. In this study, we demonstrated that erianin can hamper OSCC cells growth both in vitro and in vivo. Erianin induced obvious G2/M arrest as well as apoptosis and gasdermin E (GSDME)-dependent pyroptosis in OSCC cells. Moreover, erianin increased autophagosome formation but decreased autolysosome function. Further study indicated that erianin significantly suppressed the expression of protein-palmitoyl thioesterase 1 (PPT1) and mTOR signaling. PPT1 has been reported to be a critical regulator of cancer progression by its modulation of autophagy and mTOR signaling. According to online databases, higher expression of PPT1 has been observed in OSCC tissues and is associated with poorer patient prognosis. As overexpression of PPT1 significantly reversed erianin-induced growth inhibition in OSCC cells, we identified the importance of PPT1 reduction in erianin-induced growth suppression. With the xenograft model, we confirmed the antitumor effect of erianin in vivo. Erianin efficiently decreased the tumor sizes, together with visibly reduced expression of PPT1 and phosphorylation of mTOR in the xenograft tumor tissues. Therefore, the present study indicated that erianin may be potentially used in OSCC therapy.

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“…Notably, about 40% of OSCC patients may have metastasis ( 5 ). In addition, for non-metastatic patients, local resection of the primary tumor can achieve an ideal therapeutic effect, while metastatic patients generally need neck lymph node dissection, which not only increases the risk of surgery but also often causes postoperative dysfunction and maxillofacial deformities ( 6 , 7 ). Whereas, it is still difficult to accurately determine whether OSCC patients have metastasis before surgery, which may lead to over-medical treatment (performing neck dissection for patients without lymph node metastasis) or insufficient treatment (patients with lymph node metastasis did not undergo neck dissection).…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

Jiang²,

Shao³

et al. 2021

Front. Oncol.

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Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Metastasis is the main cause of the death of OSCC patients. Long noncoding RNAs (lncRNAs), one of the key factors affecting OSCC metastasis, are a subtype of RNA with a length of more than 200 nucleotides that has little or no coding potential. In recent years, the important role played by lncRNAs in biological processes, such as chromatin modification, transcription regulation, RNA stability regulation, and mRNA translation, has been gradually revealed. More and more studies have shown that lncRNAs can regulate the metastasis of various tumors including OSCC at epigenetic, transcriptional, and post-transcriptional levels. In this review, we mainly discussed the role and possible mechanisms of lncRNAs in OSCC metastasis. Most lncRNAs act as oncogenes and only a few lncRNAs have been shown to inhibit OSCC metastasis. Besides, we briefly introduced the research status of cancer-associated fibroblasts-related lncRNAs in OSCC metastasis. Finally, we discussed the research prospects of lncRNAs-mediated crosstalk between OSCC cells and the tumor microenvironment in OSCC metastasis, especially the potential research value of exosomes and lymphangiogenesis. In general, lncRNAs are expected to be used for screening, treatment, and prognosis monitoring of OSCC metastasis, but more work is still required to better understand the biological function of lncRNAs.

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Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma

Cited by 21 publications

References 30 publications

<p>Short-Term Quality of Life, Functional Status, and Their Predictors in Tongue Cancer Patients After Anterolateral Thigh Free Flap Reconstruction: A Single-Center, Prospective, Comparative Study</p>

<p>Short-Term Quality of Life, Functional Status, and Their Predictors in Tongue Cancer Patients After Anterolateral Thigh Free Flap Reconstruction: A Single-Center, Prospective, Comparative Study</p>

PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells

Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma

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