Long-term stability of sensitivity to intracortical microstimulation of somatosensory cortex

Callier, Thierri; Schlüter, E.; Tabot, Gregg; Miller, Lee E.; Tenore, Francesco V.; Bensmaı̈a, Sliman J.

doi:10.1088/1741-2560/12/5/056010

Cited by 40 publications

(36 citation statements)

References 45 publications

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“…The age of the implanted arrays used in these studies ranged from 2 mo to 4 y. The stability of sensitivity to ICMS in area 1 over multiple years has been documented (29).…”

Section: Methodsmentioning

confidence: 99%

The frequency of cortical microstimulation shapes artificial touch

Callier

Brantly

Caravelli

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Intracortical microstimulation (ICMS) of the somatosensory cortex evokes vivid tactile sensations and can be used to convey sensory feedback from brain-controlled bionic hands. Changes in ICMS frequency lead to changes in the resulting sensation, but the discriminability of frequency has only been investigated over a narrow range of low frequencies. Furthermore, the sensory correlates of changes in ICMS frequency remain poorly understood. Specifically, it remains to be elucidated whether changes in frequency only modulate sensation magnitude—as do changes in amplitude—or whether they also modulate the quality of the sensation. To fill these gaps, we trained monkeys to discriminate the frequency of ICMS pulse trains over a wide range of frequencies (from 10 to 400 Hz). ICMS amplitude also varied across stimuli to dissociate sensation magnitude from ICMS frequency and ensure that animals could not make frequency judgments based on magnitude. We found that animals could consistently discriminate ICMS frequency up to ∼200 Hz but that the sensory correlates of frequency were highly electrode dependent: On some electrodes, changes in frequency were perceptually distinguishable from changes in amplitude—seemingly giving rise to a change in sensory quality; on others, they were not. We discuss the implications of our findings for neural coding and for brain-controlled bionic hands.

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“…The age of the implanted arrays used in these studies ranged from 2 mo to 4 y. The stability of sensitivity to ICMS in area 1 over multiple years has been documented (29).…”

Section: Methodsmentioning

confidence: 99%

The frequency of cortical microstimulation shapes artificial touch

Callier

Brantly

Caravelli

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

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“…Similar probes have also been used for chronic recordings in freely behaving animals (Michon et al, 2016 ) and interfaced with telemetric devices (Fan et al, 2011 ), which may even allow researchers to investigate high-order sensorimotor and sociocognitive functions in freely behaving large animals, such as nonhuman primates. Although we did not monitor the stability over time of ICMS-evoked behavioral effects, it has been shown in previous studies that they remain stable over periods of several months with chronically implanted electrode arrays (Callier et al, 2015 ).…”

Section: Discussionmentioning

confidence: 98%

Comparative Performance of Linear Multielectrode Probes and Single-Tip Electrodes for Intracortical Microstimulation and Single-Neuron Recording in Macaque Monkey

Ferroni

Maranesi

Livi

et al. 2017

Front. Syst. Neurosci.

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Intracortical microstimulation (ICMS) is one of the most widely employed techniques for providing causal evidence of the relationship between neuronal activity and specific motor, perceptual, or even cognitive functions. In recent years, several new types of linear multielectrode silicon probes have been developed, allowing researchers to sample neuronal activity at different depths along the same cortical site simultaneously and with high spatial precision. Nevertheless, silicon multielectrode probes have been rarely employed for ICMS studies and, more importantly, it is unknown whether and to what extent they can be used for combined recording and stimulation experiments. Here, we addressed these issues during both acute and chronic conditions. First, we compared the behavioral outcomes of ICMS delivered to the hand region of a monkey's motor cortex with multielectrode silicon probes, commercially available multisite stainless-steel probes and single-tip glass-coated tungsten microelectrodes. The results for all three of the probes were reliable and similar. Furthermore, we tested the impact of long-train ICMS delivered through chronically implanted silicon probes at different time intervals, from 1 to 198 days after ICMS sessions, showing that although the number of recorded neurons decreased over time, in line with previous studies, ICMS did not alter silicon probes' recording capabilities. These findings indicate that in ICMS experiments, the performance of linear multielectrode silicon probes is comparable to that of both single-tip and multielectrode stainless-steel probes, suggesting that the silicon probes can be successfully used for combined recording and stimulation studies in chronic conditions.

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“…Our findings allow us to speculate that the intracorticalmicrostimulation could be combined with the BONP in awake transgenic-animals expressing ChR2. This could be beneficial for the development of new technologies for long-lasting intracortical microstimulation with brain-machine interfaces in animal models (Callier et al, 2015); which is of importance for future clinical applications in the human brain.…”

Section: Discussionmentioning

confidence: 99%

Noisy Light Augments the Na+ Current in Somatosensory Pyramidal Neurons of Optogenetic Transgenic Mice

et al. 2020

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Long-term stability of sensitivity to intracortical microstimulation of somatosensory cortex

Abstract: Given the stability of the sensations that it evokes, ICMS may thus be a viable approach for sensory restoration.

Cited by 40 publications

References 45 publications

The frequency of cortical microstimulation shapes artificial touch

The frequency of cortical microstimulation shapes artificial touch

Comparative Performance of Linear Multielectrode Probes and Single-Tip Electrodes for Intracortical Microstimulation and Single-Neuron Recording in Macaque Monkey

Noisy Light Augments the Na+ Current in Somatosensory Pyramidal Neurons of Optogenetic Transgenic Mice

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