Long-term stable measurement phantoms for magnetic particle imaging

Wöckel, Lucas; Wells, James; Kosch, Olaf; Lyer, Stefan; Grüttner, Cordula; Wiekhorst, Frank; Dutz, Silvio

doi:10.1016/j.jmmm.2018.09.012

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…Furthermore, it will be investigated whether new material compositions can be used to generate MR signals similar to other soft tissues with longer relaxation times, such as white matter. Furthermore, it is possible to introduce MPI tracers directly into the still liquid photopolymers [ 8 , 15 ] and to process them afterwards by AM. Since the MPI tracers obliterate the MR signal, multi-material DLP printers must be used to produce compartments with and without MPI tracers [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…In MPI imaging, it is advantageous if the phantoms serve both imaging modalities, MPI and MRI, simultaneously. MPI phantoms are usually solid bodies with cavities of different sizes and geometries filled with different concentrations of MPI tracer [ 6 , 7 , 8 ]. Biomimetic phantoms with cavities corresponding to anatomical geometries are used to simulate the uptake of MPI tracer in a given organ [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of Phantoms for Multimodal Magnetic Resonance Imaging and Magnetic Particle Imaging

et al. 2022

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Phantoms are crucial for the development of imaging techniques based on magnetic nanoparticles (MNP). They serve as test objects to simulate application scenarios but are also used for quality assurance and interlaboratory comparisons. Magnetic particle imaging (MPI) is excellent for specifically detecting magnetic nanoparticles (MNP) without any background signals. To obtain information about the surrounding soft tissue, MPI is often used in combination with magnetic resonance imaging (MRI). For such application scenarios, this poses a challenge for phantom fabrication, as they need to accommodate MNP as well as provide MR visibility. Recently, layer-by-layer fabrication of parts using Additive Manufacturing (AM) has emerged as a powerful tool for creating complex and patient-specific phantoms, but these are characterized by poor MR visibility of the AM material. We present the systematic screening of AM materials as candidates for multimodal MRI/MPI imaging. Of all investigated materials, silicone (Dreve, Biotec) exhibited the best properties with sufficient MR-signal performance and the lowest absorption of MNP at the interface of AM materials. With the help of AM and the selection of appropriate materials, we have been able to produce suitable MRI/MPI phantoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Phantoms for Multimodal Magnetic Resonance Imaging and Magnetic Particle Imaging

et al. 2022

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“… 5 The creation of imaging phantoms has evolved due to recent advances with three‐dimensional (3D) printing, which has enabled rapid, low‐cost, and reproducible phantom development. 6 3D‐printed phantoms for MPI studies have been primarily utilized to evaluate instrument performance 7 , 8 , 9 and SPION tracer characteristics 10 , 11 to ensure reproducibility of experiments in the field. In addition, phantoms have been used to explore potential biomedical applications of MPI such as magnetic hyperthermia, 12 measurement of blood flow velocity, 13 quantification of vascular stenoses, 14 and stent placement guidance.…”

Section: Introductionmentioning

confidence: 99%

“…5 The creation of imaging phantoms has evolved due to recent advances with three-dimensional (3D) printing, which has enabled rapid, low-cost, and reproducible phantom development. 6 3D-printed phantoms for MPI studies have been primarily utilized to evaluate instrument performance [7][8][9] and SPION tracer characteristics 10,11 to ensure reproducibility of experiments in the field.…”

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confidence: 99%

An anatomically correct 3D‐printed mouse phantom for magnetic particle imaging studies

Sarna

Marrero-Morales

DeGroff

et al. 2022

Bioengineering & Transla Med

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We report anatomically correct 3D‐printed mouse phantoms that can be used to plan experiments and evaluate analysis protocols for magnetic particle imaging (MPI) studies. The 3D‐printed phantoms were based on the Digimouse 3D whole body mouse atlas and incorporate cavities representative of a liver, brain tumor, and orthotopic breast cancer tumor placed in anatomically correct locations, allowing evaluation of the effect of precise doses of MPI tracer. To illustrate their use, a constant tracer iron mass was present in the liver for the breast (200 μgFe) and brain tumor (10 μgFe) model, respectively, while a series of decreasing tracer iron mass was placed in the tumor region. MPI scans were acquired in 2D and 3D high sensitivity and high sensitivity/high resolution (HSHR) modes using a MOMENTUM imager. A thresholding algorithm was used to define regions of interest (ROIs) in the scans and the tracer mass in the liver and tumors was calculated by comparison of the signal in their respective ROI against that of known mass fiducials that were included in each scan. The results demonstrate that this approach to image analysis provides accurate estimates of tracer mass. Additionally, the results show how the limit of detection in MPI is sensitive to the details of tracer distribution in the subject, as we found that a greater tracer mass in the liver cavity resulted in poorer sensitivity in tumor regions. These experiments illustrate the utility of the reported 3D‐printed anatomically correct mouse phantoms in evaluating methods to analyze MPI scans and plan in vivo experiments.

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“…[17][18][19] Currently, there are ve commercially available MNP preparations exploited in magnetic particle imaging (MPI) such as Perimag (micromod Partikeltechnologie, Rostock, Germany), FerraSpin-R (nanoPET-Pharma, Berlin, Germany), uidMag-D 50 (chemicell, Berlin, Germany), Ferucarbotran (Meito Sangyo, Nagoya, Japan) and SEONLA-BSA (SEON group, Erlangen, Germany). 20 Earlier applications of MPI focused on vascular imaging such as 3D imaging of a beating mouse heart using commercial nanoparticle suspensions, like Resovist, composed of super-paramagnetic iron oxide MNPs. 21 Furthermore, studies have shown that synergies between magnetic particle imaging and magnetic hyperthermia goes through the design of better scanners and an improvement of the current resolution.…”

Section: Introductionmentioning

confidence: 99%