Long-term supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood

Moberget, Torgeir; Andersson, Stein; Lundar, Tryggve; Due-Tønnessen, Bernt Johan; Heldal, Anne Taraldsen; Endestad, Tor; Westlye, Lars T.

doi:10.1016/j.neuropsychologia.2015.02.007

Cited by 37 publications

(30 citation statements)

References 116 publications

(148 reference statements)

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“…Maldevelopment of the cerebellum may lead to structural and functional abnormalities of fronto-limbic brain structures that in MDD and BPD are more commonly associated with pathophysiology ( Reeber et al, 2013 ). Indeed, cerebellar tumor resection during early childhood leads to cognitive dysfunction and associated structural deficits of the cortex and hippocampus ( Moberget et al, 2015 ). Consequently, it is plausible that increased HHV-6A and HHV-6B infection in BPD and MDD presented here, could impact structure and function of fronto-limbic brain regions; highlighting the need for future studies of HHV-6A and HHV-6B in other brain regions.…”

Section: Discussionmentioning

confidence: 99%

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

et al. 2018

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Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can later be activated causing cognitive and behavioral disturbances. Hence, this study was designed to evaluate possible association of HHV-6A and HHV-6B activation with three different groups of psychiatric patients. DNA qPCR, immunofluorescence and FISH studies were carried out in post-mortem posterior cerebellum from 50 cases each of bipolar disorder (BPD), schizophrenia, 15 major depressive disorder (MDD) and 50 appropriate control samples obtained from two well-known brain collections (Stanley Medical Research Institute). HHV-6A and HHV-6B late proteins (indicating active infection) and viral DNA were detected more frequently (p < 0.001 for each virus) in human cerebellum in MDD and BPD relative to controls. These roseolovirus proteins and DNA were found less frequently in schizophrenia cases. Active HHV-6A and HHV-6B infection in cerebellar Purkinje cells were detected frequently in BPD and MDD cases. Furthermore, we found a significant association of HHV-6A infection with reduced Purkinje cell size, suggesting virus-mediated abnormal Purkinje cell function in these disorders. Finally, gene expression analysis of cerebellar tissue revealed changes in pathways reflecting an inflammatory response possibly to HHV-6A infection. Our results provide molecular evidence to support a role for active HHV-6A and HHV-6B infection in BPD and MDD.

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Section: Discussionmentioning

confidence: 99%

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

et al. 2018

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“…Several studies have investigated the effects of tumor location on long-term neurocognitive functioning. The cerebellum, with its connections to extensive regions of the cerebrum, is the most common site of PBTs, and is known to be involved in both motor and cognitive functions, including EF (Moberget et al, 2015). The cerebellum appears to play a crucial role during neurodevelopment, as lesions to the cerebellum and disruptions of the cerebellocerebral connectivity in children generally lead to more pronounced neurocognitive deficits than in adults (Ailion et al, 2016;Moberget et al, 2015).…”

Section: Medical Late Effectsmentioning

confidence: 99%

“…The cerebellum, with its connections to extensive regions of the cerebrum, is the most common site of PBTs, and is known to be involved in both motor and cognitive functions, including EF (Moberget et al, 2015). The cerebellum appears to play a crucial role during neurodevelopment, as lesions to the cerebellum and disruptions of the cerebellocerebral connectivity in children generally lead to more pronounced neurocognitive deficits than in adults (Ailion et al, 2016;Moberget et al, 2015). Moreover, some findings suggest that patients with infratentorial tumors (i.e., below the tentorium) have greater neurocognitive impairments than those with supratentorial tumors (i.e., above the tentorium) (Stavinoha et al, 2018).…”

Section: Medical Late Effectsmentioning

confidence: 99%

“…It is now generally acknowledged that EFs rely greatly on the intactness of multiple cooperating cortical and subcortical networks, and that the prefrontal regions may be viewed as analog to a "conductor" or orchestrator of EF skills (Gioia et al, 2001;Goldberg, 2001;Kalbfleisch, 2017;Stuss & Alexander, 2000). EFs are therefore vulnerable not only to frontal lobe lesions, but also to lesions in other parts of the brain, for example the cerebellum, a common site for PBT (Anderson, Jacobs, & Harvey, 2008;Moberget et al, 2015;Riva & Giorgi, 2000). Furthermore, as the structural maturation and remodeling of the frontal lobes is prolonged, spanning from infancy to young adulthood, so is the developmental trajectory of EFs, thus creating a vulnerability to damages at any time point of brain development (De Luca & Leventer, 2008).…”

Section: Conceptualizations and Developmental Modelsmentioning

confidence: 99%

“…Today, the terms "executive functions" and "frontal lobe functions" are no longer used interchangeably, as it has become clear that these functions rely not only on the frontal lobes, but also on the intactness of multiple cooperating brain structures and networks (Gioia, Isquith, & Guy, 2001;Kalbfleisch, 2017;Stuss & Alexander, 2000). For example, the cerebellum, which is the most frequent location for PBTs, has rich neuroanatomical connections to the rest of the brain, including the frontal lobes, and thus plays a crucial role in EF and their development (Moberget et al, 2015;Stoodley & Schmahmann, 2009). Also, it has been acknowledged that the developmental trajectory of EFs is prolonged, spanning across the first three decades of life, paralleling the structural maturation and remodeling of the frontal lobes (Anderson, 2010;De Luca & Leventer, 2008) .…”

Section: Introductionmentioning

confidence: 99%

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Self-Reported Executive Dysfunction, Fatigue, and Psychological and Emotional Symptoms in Physically Well-Functioning Long-Term Survivors of Pediatric Brain Tumor

Puhr

Anderson

Due-Tønnesen

et al. 2018

Developmental Neuropsychology

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Completing this thesis has been one of most arduous ordeals I have taken on, but also one of the most educational, satisfying, and now at the end of it all, liberating, empowering and relieving experiences I might ever have had. The relief of completing is most likely not only felt by me; I imagine several people around me may feel somewhat relieved themselves to see that I finally reached the finish line. Parallel to working on this thesis, these years since I first started have been the most eventful of my life, both good and bad. I lost a father, but gained the two great loves of my life; my daughters, Eira and Frida. These two little girls have no doubt largely contributed to keeping me sane throughout this process, and have reminded me along the way of what really matters. The same must be said for Vegard; I am profoundly thankful for your patience, support, and for being my rock in all our years together. Thank you. And to my family and friends, thank you all for your kind, supportive words and understanding. I would like to thank one person in particular who has been of invaluable support to me in all things that matter; my friend, colleague and co-author, Anne-Britt Skarbø. I cannot express how much I appreciate how you have encouraged and cheered me on throughout this long process, in moments when I needed it the most. A very special thank you also to cocheerleader and former colleague, Torhild Berntsen, a strong and inspiring advocate for children with acquired brain injury, who initiated the idea of a study investigating long-term functioning in survivors of childhood brain tumor, and who has believed in this study ever since. I am very proud to present the final product of this study! This is all my own product; from forming the idea for the project, to achieving funding, collecting data, and finally, reporting findings. However, none of this could have been achieved without my team players. First of all, to my main supervisor, Stein Andersson. Stein, you have been the ideal supervisor in my view; knowledgeable, steadfast, straightforward, encouraging, easy going, providing clarity and a dash of pragmatism, and calming my nerves in a moment or two of frustration. Thank you for sticking with me throughout this endeavor! Also, a special thank you to my cosupervisors, Ellen Ruud and Arnstein Finset. To Ellen, for immediately believing in and contributing to the project from the beginning, and for guiding me through the jungle that it is to implement a clinical study, and to Arnstein, for sharing your valuable academic experience and insights.

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Cerebellar Agenesis

Romaniello

Borgatti

2021

Handbook of the Cerebellum and Cerebellar Disorders

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Cerebellar agenesis is an extremely rare condition in which patients show minute cerebellar tissue, usually corresponding to remnants of the lower cerebellar peduncles, anterior vermal lobules, and flocculi. Clinical presentation of cerebellar agenesis may cover a broad phenotypic spectrum of disabilities including not only motor disorders but also cognitive abilities, language disabilities, and affective disorders. The severity and range of motor, cognitive, and psychiatric impairments appears to be correlated with the earliness, localization, and extent of the agenesis of the cerebellum. Patients with congenital malformations display,

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Long-term supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood

Cited by 37 publications

References 116 publications

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

Self-Reported Executive Dysfunction, Fatigue, and Psychological and Emotional Symptoms in Physically Well-Functioning Long-Term Survivors of Pediatric Brain Tumor

Cerebellar Agenesis

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