Long-Term Survival of an Elderly Patient with Carcinosarcoma of the Gallbladder after Cholecystectomy

Abstract

Carcinosarcomas, often referred to as malignant mixed tumors, are rare neoplasm. We reported herein a carcinosarcoma of the gallbladder in an elderly patient with long-term survival (4 years). The operation carried out was open cholecystectomy under the preoperative diagnosis of chronic cholecystitis and tumor of the gallbladder. Anticancer chemotherapy after cholecystectomy was performed by oral low-dose FT therapy. He was alive with no evidence of disease 48 months after surgery. Long-term survival for only cholecystectomy treatment as in this case may be possible if oral low-dose FT anticancer therapy is effective against carcinosarcoma of the gallbladder.

Carcinosarcoma of the Gallbladder with Chondrosarcomatous Differentiation and Intracytoplasmic Eosinophilic Hyaline Globules (Thanatosomes): A Report of a Case and Review of the Literature

“…Their ages ranged from 38 to 91 years (Mean age 67 years). In addition to the presence of chondroid differentiation, twelve tumors showed additional osteoid differentiation [5, 7, 17, 21, 22, 25, 28, 31, 33, 36, 38, 39], two cases showed additional rhabdomyosarcomatous differentiation only [7, 26], and one case showed additional both rhabdomyosarcomatous and osteoid differentiation [24]. Metastatic spread, particularly to the liver was documented in 18 cases (62%).…”

“…Allover survival was 13.5 months, ranging from 0 to 54 months. Prolonged survival had been emphasized in two patients, one survived 48 months [31], and the other 54 months [29].…”

“…Abdominal mass, fever, nausea, vomiting, abdominal pain, anorexia, loss of weight, and painless jaundice are some of the nonspecific presentations of this tumor [24, 31]. Our patient was admitted initially to the Emergency Department due to abdominal pain with vomiting but without jaundice.…”

Carcinosarcoma of the Gallbladder: A Rare Tumor

“…Of these reports, most patients (83%) had documented gallstones. The size of the tumor on initial diagnosis was reported in 63 patients only, while in 13 cases [11][12][13][14][15][16][17][18][19][20][21][22][23] the tumor size was not available. Average tumor size on initial diagnosis by the different radiological tests used (US, CT and MRI scan) has a wide range of variability.…”

Clinicopathologic Analysis of Gallbladder Carcinosarcoma

“…Long-term survival after surgical treatment might be possible if the tumor was restricted within the gallbladder serosa. 3…”