Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain

Xing, Guo-Gang; Liu, Fengyu; Qu, Xiao-Xiu; Han, Ji-Sheng; Wan, You

doi:10.1016/j.expneurol.2007.09.004

Cited by 112 publications

(80 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanical allodynia in the SNL rats with neuropathic nociception was comparable to the results reported earlier [16,17,21,22] . Here the electrophysiological studies showed that L5 SNL resulted in sensitization of spinal WDR neurons, including an enlargement of receptive field size, an increase in the proportion of WDR neurons that exhibited spontaneous activity, decreases of C-response threshold and latency and an increase in the C-response duration.…”

Section: Discussionsupporting

confidence: 90%

“…allodynia, a behavioral measurement of neuropathic pain, was assessed by measuring 50% paw withdrawal threshold (PWT) as described in the previous reports [16,17] . The 50% PWT in response to a series of von Frey filaments was determined by the up and down method [18] and was calculated as previously described [19] .…”

Section: Assessment Of Mechanical Allodynia Mechanicalmentioning

confidence: 99%

See 1 more Smart Citation

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Liu

Cai

et al. 2011

Neurosci. Bull.

Self Cite

View full text Add to dashboard Cite

Objective The present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats with neuropathic pain induced by lumber 5 (L5) spinal nerve ligation (SNL) in a large size of samples. Methods Adult Sprague-Dawley rats were divided into normal and SNL groups. Electrophysiological technique was used to record the characteristics of WDR neurons in the spinal dorsal horn. Results Compared with the WDR neurons in normal rats, the WDR neurons in SNL rats showed an increase in excitability, manifested by an enlargement of the receptive field size, an increase in the proportion of neurons that exhibited spontaneous activities, decreases in the Cresponse threshold and latency, and an increase in the C-response duration. In addition, the numbers of A  -and C-fiberevoked discharges were smaller in SNL rats than in normal rats. Conclusion The excitability of spinal WDR neurons increased in rats with neuropathic pain induced by L5 SNL. The increase in excitability of WDR neurons may contribute to the development of neuropathic pain.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Assessment Of Mechanical Allodynia Mechanicalmentioning

confidence: 99%

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Liu

Cai

et al. 2011

Neurosci. Bull.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Low frequency electroacupuncture has previously been shown to reduce C-fiber-evoked nerve volleys in the dorsal horn following sciatic nerve stimulation. However, this effect was inhibited by the opioid receptor antagonist naloxone; thus suggesting that endogenous opioids may also have a role in modifying pain signals (20). Future studies should investigate the underlying mechanisms of Tuina massage modified pain signaling.…”

Section: Discussionmentioning

confidence: 99%

Analgesic effects of Chinese Tuina massage in a rat model of pain

Jiang

Hao

Fang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Previous clinical trials have suggested that theChinese Tuina massage may exert transient analgesic effects. However, further investigation regarding the underlying mechanism has been hindered by the lack of a suitable animal model of pain. The present study established a rat model of hind leg pain by injecting 5.8% hypertonic saline solution (HSS) into the left gastrocnemius muscle. The effects of various Tuina massages on the pain thresholds of the rats were then measured. In addition, the effects of ipsilateral and contralateral Tuina massages on C-fiber-evoked field potentials following electrical stimulation of the left sciatic nerve were determined. Alterations in the gastrocnemius muscle tissues following various Tuina applications were investigated using hematoxylin and eosin, and desmin staining, as well as malondialdehyde and superoxide dismutase assays. Heavy hand pressure transiently reduced the pain sensitivity of both posterior limbs, despite HSS only being injected into the left hind leg. Tuina massage treatments that lasted for 15 min were associated with the best results and an absence of local tissue changes. The results of electrical sciatic nerve stimulation demonstrated that ipsilateral and contralateral Tuina massage may decrease the level of peripheral nociceptive C-fiber activity. In the present study, the Chinese Tuina massage exerted analgesic effects in a rat model of pain, which did not involve tissue damage, following a 15 min massage. Therefore, the rat model of pain used in the present study may provide a novel approach for investigating the molecular and physiological mechanisms underlying the therapeutic effects of Tuina massage. IntroductionNociception is a sensory process that leads to pain triggered by nociceptors, which are primary sensory neurons that respond to thermal, mechanical or chemical stimuli (1). There are various major pain theories, including the intensity theory of pain, which postulates that any sensory stimulus with enough intensity can generate pain (2). The peripheral pattern theory suggests that pain is produced by intense stimulation of all skin fiber endings (3), which contradicts the specificity theory, which proposes that there are numerous types of sensory receptors, with each one responding to a specific type of stimuli (4). All of these theories propose that pain is induced by the hyperstimulation of sensory receptors; however, research has suggested that pain may be associated with other sensory stimuli, such as touch (5).The Chinese Tuina massage is a traditional hand massage, which has previously been associated with pain relief. There are six main styles of physical Tuina therapy, including wobbling, rubbing, vibrating, squeezing, knocking and articular moving. Squeezing involves pressing, pinching, kneading, grasping and rubbing, and is commonly used in Tuina pain treatments (6). Constant softness and penetration under consistent intensities, frequencies and manipulation durations are applied to all styles of Tuina. Clinical practice h...

show abstract

“…Evidence from animal studies has demonstrated that acupuncture stimulation can facilitate the release of certain neuropeptides in the central nervous system (CNS), eliciting profound physiological effects and even activating selfhealing mechanisms [2][3][4]. Studies of electroacupuncture in rats revealed that both low-frequency and high-frequency stimulation could induce analgesia, but that there are differential effects of low-and high-frequency acupuncture on the types of endorphins released [5].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Bai¹,

Qin²,

Liang³

et al. 2009

CMIR

View full text Add to dashboard Cite

Acupuncture, an ancient therapeutic technique, is currently gaining popularity as an important modality of alternative and complementary medicine in the West world. Concurrently, scientific interests in exploring whether acupuncture is therapeutically effective are raised alongside those about the means by which it may operate. Modern neuroimaging techniques such as functional magnetic resonance imaging, positron emission tomography, electroencephalography, and magnetoencephalography provide a means to safely monitor brain activity in humans. In this review, we have summarized evidence derived from the neuroimaging studies and tried to elucidate the neurophysiological correlates of acupuncture. Previous investigations on the neural responses to acupuncture mainly focus on its acute effects and explore the correlation between the specific acupoints and cortical activations only in the spatial domain. However, abundant clinical reports and psychophysical analysis suggest the kinetics of acupuncture is longer acting as a function of time. Consequentially, an accurate interpretation of acupuncture actions depends on how effectively we can characterize the nature of temporal variations underlying neural activities, rather than simply detect the occurrence of such changes. This emerging picture indicates that both designing paradigms and statistical models involved in acupuncture studies should be applied with great care.

show abstract

Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain

Cited by 112 publications

References 65 publications

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation

Analgesic effects of Chinese Tuina massage in a rat model of pain

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Contact Info

Product

Resources

About