1987
DOI: 10.1016/0278-6915(87)90287-0
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Long-term toxicity study of amaranth in rats using animals exposed in utero

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Cited by 27 publications
(24 citation statements)
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“…Mutation Research, v. 206, n. 4, p. 467-470, 1988 a weak mutagen. Clode et al (1987) showed that at doses up to 1250 mg/kg/day in rats, this colorant showed no adverse effects on fertility, hematological parameters, and serum chemistry or tumor incidence. Borzelleca and Hallagan (1988) also showed that tartrazine was not toxic or carcinogenic in a chronic study on rats.…”
Section: Chromosomal Aberration Testmentioning
confidence: 99%
“…Mutation Research, v. 206, n. 4, p. 467-470, 1988 a weak mutagen. Clode et al (1987) showed that at doses up to 1250 mg/kg/day in rats, this colorant showed no adverse effects on fertility, hematological parameters, and serum chemistry or tumor incidence. Borzelleca and Hallagan (1988) also showed that tartrazine was not toxic or carcinogenic in a chronic study on rats.…”
Section: Chromosomal Aberration Testmentioning
confidence: 99%
“…Apart from the effects of Amaranth on body weight and on caecal weight in the F1 generation, the main treatment-related effects seen in the study were on the kidneys of female rats (Clode et al, 1987). High-dose females excreted more protein in the urine after 18 months and on histopathological examination females in all treated groups showed an increased incidence of renal calcification and renal pelvic epithelial hyperplasia.…”
Section: Chronic Toxicity and Carcinogenicitymentioning
confidence: 79%
“…High-dose females excreted more protein in the urine after 18 months and on histopathological examination females in all treated groups showed an increased incidence of renal calcification and renal pelvic epithelial hyperplasia. According to the authors of the study, because of the effects of Amaranth on the kidneys of the females, it was not possible to identify a no-untoward-effect level in this study (Clode et al, 1987). The renal changes appeared specific for female rats as no treatment-related renal changes were observed in male rats.…”
Section: Chronic Toxicity and Carcinogenicitymentioning
confidence: 81%
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“…2) was banned for its association with an increased incidence in embryotoxicity as well as renal pelvis hyperplasia and calcifi cation. 80,81 Lipidsoluble formulations of erythrosine (FD & C Red No. 3) were banned because of the increased incidence of thyroid tumors in male rats fed this dye.…”
Section: Coloring Agentsmentioning
confidence: 99%