Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity

Qi, Zhengtang; Xia, Jie; Xue, Xiangli; He, Qing; Liu, Ji; Ding, Shuzhe

doi:10.1016/j.jnutbio.2016.07.005

Cited by 33 publications

(26 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAM administration (100 mg/kg/day for 8 weeks) resulted in increased lipid levels and decreased glycogen content in skeletal muscle of rats, which was associated with increased levels of lipids in the muscle, and probably due to reduced capacity of free fatty acid oxidation (Qi et al 2016). NAM (vitamin B3) is the only vitamin which can be synthesized.…”

Section: Discussionmentioning

confidence: 99%

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

et al. 2017

View full text Add to dashboard Cite

Nicotinamide (NAM) could enhance the availability of NAD ? and be beneficial to cell function. However, NAM can inhibit the activities of SIRT1 and PARP. The effect of NAM supplementation on the aging process is not well known. In the present study exogenous NAM (1-0.5% in drinking water) was supplemented for 5 weeks and in the last 4 weeks moderate treadmill running was given to 5 mo and 28 mo old rats. The content of SIRT1 was not effected by NAM treatment alone. However, the activity of SIRT1, judged from the acetylated p53/p53 ratio, increased in both NAM treated age groups, suggesting beneficial effects of exogenous NAM. This was confirmed by the finding of increased PGC-1a and pCREB/CREB ratio in the gastrocnemius muscle of old but not young NAM treated animals. Our data suggest NAM administration can attenuate the aging process in skeletal muscle of rats, but NAM administration together with exercise training might be too great challenge to cope with in the old animals, since it leads to decreased levels of SIRT1.

show abstract

Section: Discussionmentioning

confidence: 99%

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Lipotoxicity is characterized by excessive accumulation of lipid in non-adipose tissues, including liver and muscle, leading to cellular dysfunction. Excessive triglyceride accumulation in muscle is an important contributor to obesity and insulin resistance, and it is also known as a marker of insulin resistance [14]. The increased triglyceride content in the liver and muscle of the HE offspring further con rmed that maternal low-energy diet is bene cial to the glucose homeostasis of the offspring.…”

Section: Discussionmentioning

confidence: 95%

Dietary Energy Levels from Middle to Late Gestation of Guangdong Small-Ear Spotted Pig: Effects on Body Weight, Muscle Development, and Glucose Metabolism of its Newborn Piglets

Yang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Guangdong Small-ear Spotted pigs are Chinese indigenous pig that have the characteristic of desired meat quality and resistance to coarse feeding. However, no study has elucidated the effects of dietary energy levels on body weight, muscle development and glucose metabolism of its newborn piglets. Therefore, a total of 66 pregnant gilts with an average body weight of 80.6±6.6 kg at day 60 of gestation were randomly divided into two groups: control group (CON group; 11.50 MJ/kg digestible energy), and high-energy diet group (HE group; 13.42 MJ/kg digestible energy). Results: The results showed that the maternal HE diet was shown to decrease the birth weight of piglets that from the gilts with total or alive litter size of 12 to 13. Additionally, the HE diet group were shown to impair the glucose tolerance of newborn piglets, as evidenced by the glucose tolerance test and the inhibition of insulin signaling pathway in liver and soleus muscle. Despite no significant change in the muscle weight in the two groups, the maternal HE diet was shown to downregulate the protein level of slow-twitch fiber myosin heavy chain I (MyHC I), and upregulate the protein levels of fast-twitch fiber myosin heavy chain IIb (MyHC IIb) and IIx (MyHC IIx) in soleus muscle of their progeny. Furthermore, the newborn piglets in HE group were showed a decrease in mitochondrial biogenesis in liver and soleus muscle when compared to that in CON group. Conclusions: Maternal high-energy diet from middle to late gestation decreases the birth weight of piglets that from the gilts with total or alive litter size of 12 to 13, induces the formation of glycolytic muscle fibers, and impairs glucose tolerance of their newborn piglets.

show abstract

“…Insulin resistance may further reduce the contents of musclular and hepatic glycogen, and subsequently causes T2DM. In addition, it has been reported that long-term nicotinamide intake impairs mitochondrial respiration capacity and energy production in skeletal muscle (23), which may be an alternative mechanism for Vitamin B3-induced insulin resistance and decreased glycogen synthesis in the liver and muscle.…”

Section: Discussionmentioning

confidence: 99%

Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats

et al. 2017

View full text Add to dashboard Cite

It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H₂O₂ levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H₂O₂ generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.

show abstract

Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity

Cited by 33 publications

References 74 publications

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Dietary Energy Levels from Middle to Late Gestation of Guangdong Small-Ear Spotted Pig: Effects on Body Weight, Muscle Development, and Glucose Metabolism of its Newborn Piglets

Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats

Contact Info

Product

Resources

About