Long-term Trial of Oral Treatment of Pernicious Anaemia with Vitamin-B12-Peptide

Withey, J. L.; Jones, J. H.; Kilpatrick, G. S.

doi:10.1136/bmj.1.5345.1583

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…There are two distinct mechanisms by which B12 is absorbed: 1) passive diffusion across the mucous membranes of the gastrointestinal tract ( Berlin et al, 1968 ) and 2) a receptor-mediated absorption process ( Figure 1 ). Only an estimated 1%–2% of oral B12 can be passively absorbed and therefore, high dosages of oral B12 are required to provide therapeutic benefit in cases where the receptor-mediated process malfunctions ( Withey et al, 1963 ).…”

Section: Introductionmentioning

confidence: 99%

Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?

Elangovan

Baruteau

2022

Front. Pharmacol.

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Vitamin B12 or cobalamin deficiency is a commonly encountered clinical scenario and most clinicians will have familiarity prescribing Vitamin B12 to treat their patients. Despite the high prevalence of this condition, there is widespread heterogeneity regarding routes, schedules and dosages of vitamin B12 administration. In this review, we summarise the complex metabolic pathway of Vitamin B12, the inherited and acquired causes of Vitamin B12 deficiency and subsequently highlight the disparate international practice of prescribing Vitamin B12 replacement therapy. We describe the evidence base underpinning the novel sublingual, intranasal and subcutaneous modes of B12 replacement in comparison to intramuscular and oral routes, with their respective benefits for patient compliance and cost-saving.

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Section: Introductionmentioning

confidence: 99%