Oral cobalamin remains medicine's best kept secret

Graham, Ian D.; Tetroe, Jacqueline; Robinson, Nicole; Milne, Sarah; Mitchell, Susan L.

doi:10.1016/j.archger.2006.02.003

Cited by 23 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the recommendation of oral vitamin B12 as a definitive treatment has not yet been fully validated in current clinical practice. So far, several authors have suggested that oral vitamin B12 therapy remains one of 'medicine's best kept secrets' [30]. Nevertheless, the following can be proposed: ongoing supplementation is needed until any associated disorders are corrected (e.g., by halting the ingestion of the offending medication or exogenosis, or by treating H. pylori infection or pancreatic exocrine failure) [8,29].…”

Section: Expert Opinionmentioning

confidence: 99%

Efficacy of oral cobalamin (vitamin B12) therapy

Andrès

Fothergill

Mecili

2010

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

Section: Expert Opinionmentioning

confidence: 99%

Efficacy of oral cobalamin (vitamin B12) therapy

Andrès

Fothergill

Mecili

2010

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…The procedure for oral cobalamin treatment has, however, not been completely validated yet in real life, particularly the long-term efficacy [50]. To date, as several authors suggest, oral cobalamin therapy remains one of “medicine's best kept secrets” [51]. Since loading doses of cobalamin far exceed physiologic requirements, clinical responses may result from pharmacologic effects on either cobalamin-related processes or on cellular functions completely unrelated to the known biochemical actions of cobalamin [52].…”

Section: Oral Cobalamin Therapymentioning

confidence: 99%

Cobalamin Deficiency in Elderly Patients: A Personal View

Andrès

Vogel

Fédérici

et al. 2008

Current Gerontology and Geriatrics Research

View full text Add to dashboard Cite

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

show abstract

“…The procedure for oral cobalamin treatment has, however, not been completely validated yet in real life, particularly the long-term efficacy [51]. To date, as several authors suggest, oral cobalamin therapy remains one of "medicine's best kept secrets" [52]. Nevertheless, the following can be proposed: ongoing supplementation until associated disorders is corrected (e.g.…”

Section: Oral Cobalamin Therapymentioning

confidence: 99%

Update of Food-Cobalamin Malabsorption and Oral Cobalamin Therapy

Andrès¹,

Vidal-Alaball²,

Fédérici³

et al. 2009

TOGMJ

View full text Add to dashboard Cite

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age), but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspectives. In the general population, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome, which has only recently been identified, is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well codified, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

show abstract

Oral cobalamin remains medicine's best kept secret

Cited by 23 publications

References 24 publications

Efficacy of oral cobalamin (vitamin B12) therapy

Efficacy of oral cobalamin (vitamin B12) therapy

Cobalamin Deficiency in Elderly Patients: A Personal View

Update of Food-Cobalamin Malabsorption and Oral Cobalamin Therapy

Contact Info

Product

Resources

About