Long-term use of spironolactone for acne in women: A case series of 403 patients

Garg, Vaibhav; Choi, Juliana K.; James, William D.; Barbieri, John S.

doi:10.1016/j.jaad.2020.12.071

Cited by 21 publications

(24 citation statements)

References 24 publications

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“…scribed positive experiences with spironolactone, which may represent an effective alternative to oral antibiotics for women with acne. 28,[34][35][36][37][38] The Institute of Medicine designates long-term treatments for acne as 1 of the top priorities for comparative effectiveness research, and patients in the current study were generally willing to participate in such research, which could provide important evidence to guide practice. 17,39…”

Section: Table 4 Experiences With Common Acne Treatmentsmentioning

confidence: 99%

Patient Perspectives on the Lived Experience of Acne and Its Treatment Among Adult Women With Acne

et al. 2021

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cne is responsible for a greater global burden of disease than psoriasis, cellulitis, and melanoma. [1][2][3] Not only can acne be associated with physical disfigurement, such as permanent scarring, but its emotional impact can lead to social isolation, depression, and suicidality. In fact, treatment of acne is associated with reduced symptoms of depression. [4][5][6] Given the profound association of acne with quality of life, several qualitative studies [7][8][9][10][11] have sought to understand the lived experience of acne among adolescents. These studies [7][8][9][10][11] have highlighted that acne can have important effects on social and emotional functioning, relationships, school, and work. 12 However, few studies have specifically explored the lived experience of acne in adult populations, and these studies 13,14 have been limited by small sample sizes. Because acne often persists into adulthood in women, understanding their perspectives on acne and its treatment is important to guide clinical management in this population. 15 The purpose of this study was to examine the lived experience of acne and its treatment among a large cohort of adult women. Methods Study ParticipantsFemale patients 18 to 40 years of age with moderate to severe acne were recruited from clinics at the University of Pennsylvania Health System and Dermatologists of Southwest Ohio (a INTRODUCTION Acne often persists into adulthood in women. However, few studies have specifically explored the lived experience of acne in adult populations.OBJECTIVE To examine the lived experience of acne and its treatment among a cohort of adult women. DESIGN, SETTING, AND PARTICIPANTSA qualitative analysis was conducted from free listing and open-ended, semistructured interviews of patients at a large academic health care system (University of Pennsylvania Health System) and a private practice (Dermatologists of Southwest Ohio). Fifty women 18 to 40 years of age with moderate to severe acne participated in interviews conducted between August 30, 2019, and December 31, 2020. MAIN OUTCOMES AND MEASURESFree-listing data from interviews were used to calculate the Smith S, a measure of saliency for each list item. Semistructured interviews were examined to detect themes about patient perspectives regarding their acne and its treatment.RESULTS Fifty participants (mean [SD] age, 28 [5.38] years; 24 [48%] White) described acne-related concerns about their appearance that affected their social, professional, and personal lives, with many altering their behavior because of their acne. Depression, anxiety, and social isolation were commonly reported. Participants described successful treatment as having completely clear skin over time or a manageable number of blemishes. Many participants described frustration with finding a dermatologist with whom they were comfortable and with identifying effective treatments for their acne. CONCLUSIONS AND RELEVANCEThe results of this qualitative study suggest that women with acne have strong concerns about appearance and exp...

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Section: Table 4 Experiences With Common Acne Treatmentsmentioning

confidence: 99%

Patient Perspectives on the Lived Experience of Acne and Its Treatment Among Adult Women With Acne

et al. 2021

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“…The conclusion of this study is that spironolactone is prescribed 3–7 times less than antibiotics, that it can be used in late female acne of facial and thoracic topography in doses of 100 mg for at least 2 years 13 …”

Section: Methodsmentioning

confidence: 96%

Spironolactone in dermatology

Medina

Cazarín

Magaña

2022

Dermatologic Therapy

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Spironolactone is a drug, similar in structure to aldosterone and acts as an aldosterone receptor antagonist with an anti-androgenic effect. This drug has proven to be useful in several dermatological entities, however its use has not been well explored.Its use in diseases such as acne has opened the door to the possibility of new therapies depending on the clinical manifestations of the patients, as well as its possible to use it as a first line treatment. Other diseases associated with the use of spironolactone where its effects have been shown to be useful are hidradenitis suppurativa, hirsutism, and female pattern androgenetic alopecia. In this review, we discuss the use of spironolactone in different skin diseases that are common in our environment, dosage according to different studies, treatment recommendations and adverse effects; all of the above mentioned in order to use this drug in a daily clinical practice.

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“…Spironolactone is efficient not only in clearing facial acne, but also truncal acne, which can be particularly difficult to treat. Over two-thirds of women in a recent retrospective study achieved complete clearance of their truncal acne (47). A randomized double-blind trial is currently undergoing in Nantes, France to demonstrate the superiority of spironolactone in terms of efficacy, in order to establish it as an alternative to cyclines (48).…”

Section: Treatment Of Adult Female Acnementioning

confidence: 99%

Adult female acne: Clinical and therapeutic particularities (Review)

et al. 2021

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Acne is a chronic inflammatory condition affecting the pilosebaceous unit that was traditionally viewed as a disease of the adolescence. However, over the past several years, an increasing number of adult women have been reported to suffer from this condition. The prevalence of adult female acne ranges between 12 and 54%. Two clinical types can be distinguished in this population, a 'retentional' and an 'inflammatory' type, which usually tend to overlap. In terms of evolution, three main subtypes can be identified: Persistent acne, which is the most frequent subtype, late-onset acne and recurrent acne. This type of acne is mainly mild-to-moderate in severity and may be refractory to conventional treatment. The etiopathogenesis is complex and has yet to be fully elucidated. It appears to involve an interaction among genetic predisposition, hormonal factors, and chronic activation of the innate immune system overlapping with external factors, such as daily stress, Western-type diet, use of tobacco and cosmetics. The treatment may be challenging and a holistic approach is required, with special attention to the individual needs and particularities of adult women. Both topical and systemic treatments are available, with hormonal therapies being of special value in this population. The aim of the present article was to provide up-to-date, evidence-based information on the clinical presentation, etiopathogenesis and treatment of adult female acne. Contents1. Introduction 2. Prevalence 3. Clinical presentation 4. Etiopathogenesis 5. Treatment of adult female acne 6. Conclusions

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Long-term use of spironolactone for acne in women: A case series of 403 patients

Cited by 21 publications

References 24 publications

Patient Perspectives on the Lived Experience of Acne and Its Treatment Among Adult Women With Acne

Patient Perspectives on the Lived Experience of Acne and Its Treatment Among Adult Women With Acne

Spironolactone in dermatology

Adult female acne: Clinical and therapeutic particularities (Review)

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