Long time release of water soluble drug from hydrophilic nanofibrous material

Abstract

In this study, mesoporous silica nanoparticles (MSNs) were embedded into the hydrophilic poly(vinyl alcohol) (PVA) nanofibrous mats to achieve sustained release of water soluble drug from hydrophilic nanofibrous mats. MSNs were successfully prepared based on a sol-gel method. Water soluble drug naproxen sodium was then loaded into the mesopores of the MSNs, and different amounts of the drug-loaded MSNs were further incorporated into the fibers by the electrospinning process. Morphology of the nanofibrous mats was investigated, and it was found that all the fibers exhibited fibrous structure. Interestingly, lots of protrusions could be observed from the scanning electron microscopy images with high magnification, and numbers of the protrusions increased with the increasing of loading ratios of the MSNs from 5 to 15%. In addition, the wetting behaviors of the nanofibrous mats were also measured, and the water contact angles of all the mats were measured to be 0 . Finally, the drug release results indicated that all the PVA/MSNs composite nanofibrous mats showed an obviously prolonged drug release. The optimal loading ratio of the MSNs in the nanofibers was 10% due to the slowest drug release rate.

Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

“…A variety of nanocarriers, including cationic materials, recombinant protein materials, liposomes, and vesicles, have been applied to enhance the stability of guest molecules [1,2,3]. Moreover, mesoporous silica nanoparticles (MSNs) with controllable morphology and huge specific surface areas have been widely used as drug carriers in the last few decades [4,5,6]. These nanoparticles exhibit three-stage degradation behavior in the body and can be excreted by feces or urine without changing the microstructures of the kidneys.…”

Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system

“…Recently, nanofibrous materials for loading and controlled-release therapeutic drugs have been studied due to the structural similarity of nanofibers to the extracellular matrix and the porous structure. 3 Generally, the sustainedrelease method requires direct application or 1 College of Textile and Clothing, Xin Jiang University, China 2 Key Laboratory of Textile Science & Technology (Donghua University), Ministry of Education, China microencapsulation, 4 followed by wrapping in nanofiber membranes. However, the weak interaction between microspheres and the polymer matrix often leads to separation from the electrospun nanofiber membranes, and the loading of drugs with different hydrophilic and hydrophobic properties on the nanofiber may also be limited.…”