Longer Duration of Sleep and Risk of Cognitive Decline: A Meta-Analysis of Observational Studies

Kim, Hong Bae; Myung, Seung‐Kwon; Lee, Sun-Mi; Park, Yon Chul

doi:10.1159/000454737

Cited by 28 publications

(19 citation statements)

References 51 publications

(82 reference statements)

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“…To our best knowledge, this is the first study simultaneously exploring the independent and combined association of postlunch napping duration and night-time sleep duration on risk of cognitive impairment. Several population-based studies have investigated the independent relationship between night-time sleep duration and cognitive impairment 5 19. We found that longer night-time sleep duration was independently associated with a significantly worse cognitive function (MMSE), in agreement with the majority of previous studies 7 20–22.…”

Section: Discussionsupporting

confidence: 91%

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Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study

Lin

Chen³

et al. 2018

BMJ Open

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ObjectiveTo analyse the independent and combined associations of postlunch napping duration and night-time sleep duration with risk of cognitive impairment among Chinese elderly.DesignA cross-sectional study.SettingWe analysed the data from Zhejiang Ageing and Health Cohort, a population-based survey of seven counties located in Zhejiang province in eastern China.Participants10 740 participants aged 60 years or older were included in final analysis.Primary and secondary outcome measuresCognitive impairment was assessed through Mini-Mental State Examination. Data on sleep-related characteristics was collected in the behavioural habits section within the questionnaire.ResultsRelative to participants with 1–30 min of postlunch napping, those who did not nap and who napped longer had significantly higher risks for cognitive impairment. OR of cognitive impairment were 1.41 (95% CI 1.14 to 1.75) for participants with longer night-time sleep duration (≥9 hours), compared with those sleeping 7–8.9 hours. In addition, combined effects were further identified. Participants with both longer night-time sleep duration (≥9 hours) and longer postlunch napping duration (>60 min) (OR=2.01, 95% CI 1.30 to 3.13), as well as those with both longer night-time sleep duration (≥9 hours) and appropriate postlunch napping duration (1–30 min) (OR=2.01, 95% CI 1.20 to 3.38), showed significantly higher risk of cognitive impairment than those with sleeping 7–8 hours and napping 1–30 min. Meanwhile, a 34% increase in odds of cognitive impairment was observed in participants with both shorter night-time sleep duration (5–6.9 hours) and no napping.ConclusionBoth postlunch napping duration and night-time sleep duration were independently and jointly associated with cognitive impairment, which needs verification in prospective studies.

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Section: Discussionsupporting

confidence: 91%

“…Unfortunately, epidemiological data on the association between night-time sleep duration and cognitive impairment is still inconsistent and limited. The majority of studies supported that longer self-reported night-time sleep duration was associated with cognitive impairment 5. On the contrary, some others observed no association 6 7.…”

Section: Introductionmentioning

confidence: 98%

Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study

Lin

Chen³

et al. 2018

BMJ Open

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“…However, whether change of sleep duration itself or short sleep duration is the primary cause of higher MCI risk cannot be answered by our study. www.nature.com/scientificreports www.nature.com/scientificreports/ Regarding long sleep duration, several studies showed long sleep to be associated with impaired cognitive performance 13,[40][41][42] . For instance, Ramos et al (2019) 40 found long sleep (> 9 hours) to be predictive for seven-year cognitive decline in episodic learning and memory.…”

Section: Discussionmentioning

confidence: 99%

Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

Brachem

Winkler

Tebrügge

et al. 2020

Sci Rep

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Associations of sleep characteristics with mild cognitive impairment (Mci) have been examined in cross-sectional, but rarely in longitudinal studies. incident Mci and sleep characteristics were assessed in 1,890 participants of the first and second follow-up of the Heinz Nixdorf Recall study, a populationbased cohort study in Germany (age at first follow-up 50−80 years, mean follow-up 5.2 years). MCI was assessed with extensive cognitive tests. Sleep questionnaires including pSQi (pittsburgh Sleep Quality index) were used to assess sleep quality, sleep disturbances, time asleep, and time in bed. Relative risks (RR) of developing Mci when exposed to sleep characteristics were assessed in regression models adjusted for sociodemographic and cardiovascular risk factors. poor sleep quality (pSQi > 5) (RR = 1.43, 95% CI: 1.12−1.82, fully adjusted, reference: PSQI ≤ 5) and difficulties initiating sleep (almost nightly versus never) (RR = 1.40, 0.94−2.08) were associated with incident MCI. For time in bed, the risk of MCI was increased for ≤ 5 hours (RR = 2.86, 1.24─6.60, reference:7 to <8 hours). In this longitudinal study with older participants, MCI risk was increased in persons with poor sleep quality, difficulties initiating sleep, and short time in bed. Dementia is a growing public health burden worldwide. In 2013 an estimated 44.35 million persons had a prevalent dementia 1. By 2050 it is expected that this number triples to 135.46 million prevalent dementia cases 2,3. Because no effective causal medical therapies are available for dementia, primary prevention of dementia and of its early precursors is the most promising option currently available to cap the rising prevalence 4,5. Subjects with mild cognitive impairment (MCI) have an increased risk of progression to Alzheimer's disease (AD) and other forms of dementia. Therefore, identification of modifiable risk factors for incident MCI is important, and poor sleep is considered a potential risk factor for cognitive decline and disease progression 6-13. Sleep characteristics were suggested as modifiable risk factors for cognitive decline, for example by influencing hippocampal volume 14,15. Two up-to-date reviews on this relationship indicate an association between cognitive decline and sleep problems, such as poor sleep quality, short or long sleep duration, and sleep disturbances 12,16. However, both reviews concluded that there is still a need for long term prospective studies to ensure that sleep problems precede cognitive decline 12,16. Two recently published cohort studies on sleep characteristics and dementia were not included in these reviews 17,18. Both suggest that self-reported long sleep duration as well as self-reported sleep disturbances increase the risk of dementia. Additionally, Jackowska and Cadar 19 found an association between decreased cognitive function and self-reported long and short sleep duration in their

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“…Негативное влияние нарушений сна на когнитивные функции касается все аспектов этой патологии. Метаанализ обсервационных исследований, опубликованных в PubMed, EMBASE, включивший 53 942 участника (средний возраст 66,9 года), показал, что при большей продолжительности сна относительный риск когнитивного снижения составлял 1,42 (95% ДИ 1,27-1,59) (для УКР 1,38 (95% ДИ 1,23-1,56) и для деменции 1,42 (95% ДИ 1,15-1,77)) [49].…”

Section: сонunclassified

A contemporary view of the possibilities of preventing dementia

Боголепова

2019

Medicinskij sovet

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The prevalence of dementia increases progressively, which actualizes the issue of prevention. Primary prevention of dementia involves preventing the transformation of mild cognitive impairment (MCI) into dementia, secondary prevention involves the early detection and early treatment of dementia, and tertiary prevention involves slowing down the progression of dementia. Current studies pay much attention to the correction of modifiable risk factors due to lifestyle, as primary prevention. Physical activity is a very important component of a healthy lifestyle, which is aimed at preventing the development of cognitive decline. The mechanisms of the positive effect of physical activity on cognitive functions are associated with decreased risk of cardiovascular disease, increased cerebral perfusion and cerebral blood flow, changes in neurogenesis and neuronal plasticity. Nutrition strategies focus on dieting, among which the Mediterranean diet has produced hopeful results. Sleep normalization is also considered a very important aspect of the prevention of cognitive impairment, because sleep disturbances provoke the development of cardiovascular pathology and affect the amyloid metabolism. However, along with combating risk factors, more and more attention is now being paid to the possibilities of drug treatments to prevent dementia. The experimental studies confirmed the neuroprotective effect of Akatinol (memantine). The clinical studies proved the efficacy of Akatinol in the treatment of Alzheimer’s disease and vascular dementia and showed the disease-modifying effect.

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Longer Duration of Sleep and Risk of Cognitive Decline: A Meta-Analysis of Observational Studies

Cited by 28 publications

References 51 publications

Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study

Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study

Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

A contemporary view of the possibilities of preventing dementia

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