2015
DOI: 10.1093/europace/euv117
|View full text |Cite
|
Sign up to set email alerts
|

Longer right to left ventricular activation delay at cardiac resynchronization therapy implantation is associated with improved clinical outcome in left bundle branch block patients

Abstract: AimsData on longer right to left ventricular activation delay (RV-LV AD) predicting clinical outcome after cardiac resynchronization therapy (CRT) by left bundle branch block (LBBB) are limited. We aimed to evaluate the impact of RV-LV AD on N-terminal pro–B-type natriuretic peptide (NT-proBNP), ejection fraction (EF), and clinical outcome in patients implanted with CRT, stratified by LBBB at baseline.Methods and resultsHeart failure (HF) patients undergoing CRT implantation with EF ≤ 35% and QRS ≥ 120 ms were… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
21
2
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 20 publications
(27 citation statements)
references
References 23 publications
3
21
2
1
Order By: Relevance
“…1A). This difference translated into a 77% reduction in the risk of HF or death (HR = 0.23; 95% CI 0.11-0.49; p < 0.001), after adjustment for relevant clinical covariates [25]. Similar findings were observed for all-cause mortality (Fig.…”
Section: Procedure-related Parameterssupporting
confidence: 72%
See 1 more Smart Citation
“…1A). This difference translated into a 77% reduction in the risk of HF or death (HR = 0.23; 95% CI 0.11-0.49; p < 0.001), after adjustment for relevant clinical covariates [25]. Similar findings were observed for all-cause mortality (Fig.…”
Section: Procedure-related Parameterssupporting
confidence: 72%
“…In a few small studies the RV-LV AD or QRS to LV sensed (Q-LV) delay [23,24] were able to predict the clinical and echocardiographic response to CRT. In a pro-spective study of our group, during a median follow-up of 2.2 years, 44 (35%) patients experienced HF events or death, and 36 (29%) patients died [25]. Patients with a longer activation delay (RV-LV AD ≥ 86 ms) had a lower rate of HF and death analysed cumulatively as compared to those with RV-LV AD < 86 ms. All-cause mortality occurred less frequently in the former group compared to the latter group.…”
Section: Procedure-related Parametersmentioning
confidence: 85%
“…Third, recent work has highlighted the potential survival benefit associated with electric-based LV lead implantation strategies in CRT. 27 Given the association between persistent MR and decreased survival in CRT, 3,4 our findings suggest a potential role for an electric-based optimization strategy post implant (eg, RV-LV electric distance and paced QRS width) particularly in those with nonresponse (clinical and echocardiographic) or persistent MR after CRT. Final, the impact of CRT on MR remains a point of active investigation with an emerging recognition of novel applications of LV pacing for the treatment of MR in heart failure.…”
Section: Discussionmentioning
confidence: 68%
“…First, conflicting findings about the benefits of anatomic-based lead targeting strategies 11,12 have refocused interest in electric-targeting strategies, such as LV electric delay (ie, QLV) or RV-LV electric delay. 27 Longer QLV has been associated with acute hemodynamic benefits, 10 6-month reverse remodeling, 9 and clinical outcomes 12-month postimplant. 8 With the expanding use of multisite LV Table III in the Data Supplement. †MR response was assessed in patients with >mild MR (N=225).…”
Section: Discussionmentioning
confidence: 99%
“…While the presented risk score is useful in predicting the long-term clinical outcome, it has some weaknesses, such as the lack of procedure-related parameters, e.g. the targeted coronary sinus side branch or the activation delays between the right and left ventricular leads, which might also influence the outcome of patients after CRT implantation [5].…”
mentioning
confidence: 99%