Longevity of Implantable Pulse Generators in Bilateral Deep Brain Stimulation for Movement Disorders

Niemann, Marcel; Schneider, Gerd‐Helge; Kühn, Andrea A.; Vajkoczy, Peter; Faust, Katharina

doi:10.1111/ner.12743

Cited by 23 publications

(28 citation statements)

References 32 publications

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“…Pacemaker design. Due to their excellent energy-efficiency 29 , most existing implantable pulse generators (IPGs) rely on the voltage-controlled stimulation (VCS) scheme 30 . The proposed pacemaker utilizes the VCS scheme with the core circuitry detailed in ref.…”

Section: Resultsmentioning

confidence: 99%

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu

John²,

Burkland

et al. 2020

Sci Rep

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About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers. With their flexible form factors, two pacemakers were implanted epicardially on the right and left ventricles of a porcine model and were inductively powered at 13.56 MHz and 40.68 MHz industrial, scientific, and medical (ISM) bands, respectively. The power consumption of these pacemakers is reduced to µW-level by a novel integrated circuit design, which considerably extends the maximum operating distance. Leadless BiV pacing is demonstrated for the first time in both open-chest and closed-chest porcine settings. The clinical outcomes associated with different interventricular delays are verified through electrophysiologic and hemodynamic responses. The closed-chest pacing only requires the external source power of 0.3 W and 0.8 W at 13.56 MHz and 40.68 MHz, respectively, which leads to specific absorption rates (SARs) 2-3 orders of magnitude lower than the safety regulation limit. This work serves as a basis for future wirelessly powered leadless pacemakers that address various cardiac resynchronization challenges.

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Section: Resultsmentioning

confidence: 99%

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu

John²,

Burkland

et al. 2020

Sci Rep

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show abstract

“…Out of 128 patients planned for elective IPG replacement during the recruitment period, 47 patients (24 females) could be included in the study cohort. In detail, this process was already described elsewhere . The final cohort consisted of 19 PD, 7 ET, and 21 dystonia patients.…”

Section: Resultsmentioning

confidence: 99%

“…When replacing the precursor model Kinetra® (Model 7428) with one of the currently available dual‐channel IPGs, Medtronic's Pocket Adapter (Model 64001/64002) is needed. Unfortunately, there is only little evidence on the implications of implanting such additional hardware .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Efficacy of Bilateral Deep Brain Stimulation Does Not Change After Implantable Pulse Generator Replacement but the Impedances Do: A Prospective Study

Niemann

Schneider

Kühn

et al. 2020

Neuromodulation: Technology at the Neural Interface

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“…In Niemann et al , the authors recently indicated that the published manuscript provided data with numerical errors in IPG longevities of ET patients and VIM DBS in Table 2, IPG longevities of VIM DBS of “Comparison of IPG Longevities, the Influence of Teed and Previous Replacements” section, and in the correlation coefficient of Figure 2b caption. The authors have now provided the correct numbers for this Corrigendum.…”

Section: Dbs Therapy Characteristics and Ipg Longevitymentioning

confidence: 99%