Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu, Hongming; John, Mathews; Burkland, David; Greet, Brian; Post, Allison; Babakhani, Aydin; Razavi, Mehdi

doi:10.1038/s41598-020-59017-z

Cited by 32 publications

(12 citation statements)

References 37 publications

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“…In the case of far- and near-field coupling, the range of operation is comparable to the wavelength, and higher tissue attenuation at higher frequencies causes a shorter operation distance 3 , 20 , 21 . Ultrasound power transfer techniques, which rely on vibrations to transfer power, suffer from attenuation by obstructions such as bone and muscle and they require a gel to be applied on the skin and physical contact, which limits their use 24 , 41 . In Ref.…”

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs

Habibagahi

Omidbeigi

Hadaya

et al. 2022

Sci Rep

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Neuromodulation of peripheral nerves has been clinically used for a wide range of indications. Wireless and batteryless stimulators offer important capabilities such as no need for reoperation, and extended life compared to their wired counterparts. However, there are challenging trade-offs between the device size and its operating range, which can limit their use. This study aimed to examine the functionality of newly designed wirelessly powered and controlled implants in vagus nerve stimulation for pigs. The implant used near field inductive coupling at 13.56 MHz industrial, scientific, and medical band to harvest power from an external coil. The circular implant had a diameter of 13 mm and weighed 483 mg with cuff electrodes. The efficiency of the inductive link and robustness to distance and misalignment were optimized. As a result, the specific absorption rate was orders of magnitude lower than the safety limit, and the stimulation can be performed using only 0.1 W of external power. For the first time, wireless and batteryless VNS with more than 5 cm operation range was demonstrated in pigs. A total of 84 vagus nerve stimulations (10 s each) have been performed in three adult pigs. In a quantitative comparison of the effectiveness of VNS devices, the efficiency of systems on reducing heart rate was similar in both conventional (75%) and wireless (78.5%) systems. The pulse width and frequency of the stimulation were swept on both systems, and the response for physiological markers was drawn. The results were easily reproducible, and methods used in this study can serve as a basis for future wirelessly powered implants.

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Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs

Habibagahi

Omidbeigi

Hadaya

et al. 2022

Sci Rep

Self Cite

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“…A synchronized biventricular leadless pacing system was implemented as a wirelessly energized pacemaker and presented by Lyu et al. [115]. The design was based on an inductive system involving manufactured coils in flexible polyamide implemented on the right and left ventricles of a pig's heart, operated for 13.56, 40.68 MHz, and about 11 8.5 cm as an optimum transfer distance, respectively.…”

Section: Previous Work On Near‐field Wireless Power Transfermentioning

confidence: 99%

“…(a) Photographic image of the synchronous rectifier implemented on a four‐layer printed circuit board proposed in [114]. (b) Transmitter (up) and receiver (down) of inductive coupling link pacing left ventricle proposed in [115]. (c) Magnetic resonant coupling wireless power transfer experimental setup proposed for use in a left ventricular assist device in [116].…”

Section: Previous Work On Near‐field Wireless Power Transfermentioning

confidence: 99%

Near‐field wireless power transfer used in biomedical implants: A comprehensive review

Mahmood

Gharghan

Soliman

2022

IET Power Electronics

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Wireless power transfer (WPT) techniques have been utilized in various biomedical applications to overcome the challenges of battery capacity and lifetime, and high-cost surgical interventions, using biomedical implants (BMIs) and biomedical sensors (BMSs), including deep brain stimulators, capsule endoscopes, pacemakers, and cardiac monitoring sensors. In this article, near-field WPT methods in BMIs and BMSs, including magnetic resonator coupling (MRC), inductive coupling (IC), and capacitive coupling (CC), are reviewed, and some biomedical applications of these methods are highlighted. The applications of WPT have been explored in recent years to enhance the major performance metrics of BMIs. The main topologies of MRC-WPT are presented, and the main mathematical models related to each type were extracted from previous studies and detailed here. Additionally, the main performance metrics and results achieved, along with their suggested biomedical applications, are summarized in a comparison table. Some challenges and limitations of using WPT in the biomedical field and suggestions for improving the efficiency of WPT for biomedical applications are also discussed. Furthermore, future trends in WPT-based BMIs are also highlighted.

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“…presented a wirelessly powered pacemaker implanted on the surface of the right and left ventricle (RV and LV) of a porcine heart (Figure 3f, left). [ 113 ] While conventional cardiac pacemakers are bulky owing to the battery, this research work proposed IPT‐based wireless powering for miniaturized biventricular pacing, and thus the entire module size could be miniaturized to 11 × 11 mm. The device was implemented on a flexible polyimide substrate with a thickness of 25 µm (Figure 3f, right), and thereby was compatible with the curved surface of the porcine heart.…”

Section: Wireless Poweringmentioning

confidence: 99%

Wireless Power Transfer and Telemetry for Implantable Bioelectronics

Yoo

Lee

Joo

et al. 2021

Adv Healthcare Materials

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Implantable bioelectronic devices are becoming useful and prospective solutions for various diseases owing to their ability to monitor or manipulate body functions. However, conventional implantable devices (e.g., pacemaker and neurostimulator) are still bulky and rigid, which is mostly due to the energy storage component. In addition to mechanical mismatch between the bulky and rigid implantable device and the soft human tissue, another significant drawback is that the entire device should be surgically replaced once the initially stored energy is exhausted. Besides, retrieving physiological information across a closed epidermis is a tricky procedure. However, wireless interfaces for power and data transfer utilizing radio frequency (RF) microwave offer a promising solution for resolving such issues. While the RF interfacing devices for power and data transfer are extensively investigated and developed using conventional electronics, their application to implantable bioelectronics is still a challenge owing to the constraints and requirements of in vivo environments, such as mechanical softness, small module size, tissue attenuation, and biocompatibility. This work elucidates the recent advances in RF‐based power transfer and telemetry for implantable bioelectronics to tackle such challenges.

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Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Cited by 32 publications

References 37 publications

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs

Vagus nerve stimulation using a miniaturized wirelessly powered stimulator in pigs

Near‐field wireless power transfer used in biomedical implants: A comprehensive review

Wireless Power Transfer and Telemetry for Implantable Bioelectronics

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