Longitudinal analysis of antigen specific response in individuals with Schistosoma mansoni infection in an endemic area of Minas Gerais, Brazil

Matoso, Leonardo Ferreira; Oliveira-Prado, Roberta; Abreu, Mery Natali Silva; Fujiwara, Ricardo Toshio; LoVerde, Philip T.; Kloos, Helmut; Gazzinelli, Andréa; Correa-Oliveira, Rodrigo

doi:10.1093/trstmh/trt091

Cited by 8 publications

(9 citation statements)

References 47 publications

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“…Interestingly, although the levels of IgG1 raised against RP26 and sm31 declined soon after the PZQ treatment to some extent with significance, IgG1 to serpin significantly declined at 10 weeks after the treatment. The kinetics of the IgG1 response to SEA in this study were similar to those reported by Matoso et al [ 38 ]. Their study was conducted with human sera and suggested that anti-SEA IgG4 reactivity can be used as a biomarker for the serological monitoring of S .…”

Section: Discussionsupporting

confidence: 91%

Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

et al. 2020

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Section: Discussionsupporting

confidence: 91%

Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

et al. 2020

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“…Studies in Brazil evaluating the risks of infection by Matoso et al [ 5 ] showed an increased risk in children and young adults who fished and crossed streams. Similar observations with schoolchildren have been shown by Massara et al [ 35 ], who observed that activities with both high and low water contact exposure (e.g., bathing, fishing, crossing streams, working in agriculture, watering plants and working in sand extraction) were significantly associated with infection.…”

Section: Discussionmentioning

confidence: 99%

“…mansoni infection occurs when individuals enter fecally contaminated water inhabited by infected intermediate hosts ( Biomphalaria glabrata ), the transmission of this neglected tropical disease also has a complex social, biological, and environmental basis that must be considered for successful control and elimination programs. While the importance of these factors in the occurrence of schistosomiasis has been intensively studied [ 3 – 5 ], the complexity of socioeconomic and behavioral factors can vary considerably on a local level as well as on a global scale. For example, a study conducted on the shores and islands of Lake Victoria in Nyanza Province, Kenya showed that human population density was a major factor driving Schistosoma transmission, with individual socioeconomic factors appearing not to significantly affect transmission [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling

et al. 2017

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Praziquantel (PZQ) is an effective chemotherapy for schistosomiasis mansoni and a mainstay for its control and potential elimination. However, it does not prevent against reinfection, which can occur rapidly in areas with active transmission. A guide to ranking the risk factors for Schistosoma mansoni reinfection would greatly contribute to prioritizing resources and focusing prevention and control measures to prevent rapid reinfection. The objective of the current study was to explore the relationship among the socioeconomic, demographic, and epidemiological factors that can influence reinfection by S. mansoni one year after successful treatment with PZQ in school-aged children in Northeastern Minas Gerais state Brazil. Parasitological, socioeconomic, demographic, and water contact information were surveyed in 506 S. mansoni-infected individuals, aged 6 to 15 years, resident in these endemic areas. Eligible individuals were treated with PZQ until they were determined to be negative by the absence of S. mansoni eggs in the feces on two consecutive days of Kato-Katz fecal thick smear. These individuals were surveyed again 12 months from the date of successful treatment with PZQ. A classification and regression tree modeling (CART) was then used to explore the relationship between socioeconomic, demographic, and epidemiological variables and their reinfection status. The most important risk factor identified for S. mansoni reinfection was their “heavy” infection at baseline. Additional analyses, excluding heavy infection status, showed that lower socioeconomic status and a lower level of education of the household head were also most important risk factors for S. mansoni reinfection. Our results provide an important contribution toward the control and possible elimination of schistosomiasis by identifying three major risk factors that can be used for targeted treatment and monitoring of reinfection. We suggest that control measures that target heavily infected children in the most economically disadvantaged households would be most beneficial to maintain the success of mass chemotherapy campaigns.

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“…The fraction antigen ELISA (FA-ELISA) is another modified ELISA method, which uses fractionated SEA and provides a high sensitivity and specificity in case detection, as well as providing effective assessment of the efficacy of therapy for S. japonicum infection (139). It has also been shown that IgG4 reactivity to SEA in ELISA can be used as an immune biomarker for the monitoring of infection with S. mansoni in areas of endemicity (140). Recently, the S. mansoni 200-kDa tegumental protein (Sm200) was used in an ELISA for the diagnosis of S. mansoni infection in a murine model, exhibiting more than 90% sensitivity and specificity, denoting it as a promising reagent for diagnosis (141).…”

Section: Antibody Detectionmentioning

confidence: 99%

Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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Longitudinal analysis of antigen specific response in individuals with Schistosoma mansoni infection in an endemic area of Minas Gerais, Brazil

Cited by 8 publications

References 47 publications

Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

Dynamics of serological responses to defined recombinant proteins during Schistosoma mansoni infection in mice before and after the treatment with praziquantel

Schistosoma mansoni reinfection: Analysis of risk factors by classification and regression tree (CART) modeling

Advances in the Diagnosis of Human Schistosomiasis

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