Longitudinal Analysis of Bidirectional Relationships between Nocturia and Depressive Symptoms: The Nagahama Study

Funada, Satoshi; Tabara, Yasuharu; Negoro, Hiromitsu; Akamatsu, Shusuke; Yoshino, Takayuki; Yoshimura, Koji; Watanabe, Norio; Furukawa, Toshi A; Matsuda, Fumihiko; Ogawa, Osamu

doi:10.1097/ju.0000000000000683

Cited by 19 publications

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“…Several cross-sectional studies also suggested the positive association between sleep disorder and frequency of nocturia [27, 28]. However, only a few longitudinal studies have evaluated the influence of sleep problems on nocturia [21, 25, 29]. Branche et al [29] reported a longitudinal study including 2,258 men (median age 62, IQR 58–67 years) who were evaluated by the 6 items of the Medical Outcomes Study Sleep Scale (MOS-Sleep) and IPSS for 4 years as a part of the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) study.…”

Section: Discussionmentioning

confidence: 99%

“…Although several studies reported the association between sleep problem and nocturia, clinical implication needs careful interpretation because of the background difference in the target population in each study. A community-based study or clinical trial tends to include patients from 40 to 70 years of age [20, 25, 29, 30], while a clinical practice-based study is likely to include patients from 60 to 80 years of age [20, 31]. For example, a previous study suggested that mean frequency of nocturia and age in the patients who visited the urology department due to LUTS were 2.61 and 70.9 years, respectively [31], while those in this study were 0.62 ± 0.49 and 61.4 years, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The bidirectionality association between sleep disorder and frequency of nocturia was evaluated using a cross-lagged panel analysis adjusted for age and sex. This analysis estimated standardized coefficients between 2 related variables over time and evaluated the strength of the temporal relationship [25]. Goodness of fit of the panel was evaluated by a comparative fit index (CFI ≥ 0.90), the Tucker-Lewis index (TLI ≥ 0.90), root mean square error of approximation (RMSEA ≤ 0.08), and standardized root mean square residual (SRMR ≤ 0.08) [25].…”

Section: Discussionmentioning

confidence: 99%

“…This analysis estimated standardized coefficients between 2 related variables over time and evaluated the strength of the temporal relationship [25]. Goodness of fit of the panel was evaluated by a comparative fit index (CFI ≥ 0.90), the Tucker-Lewis index (TLI ≥ 0.90), root mean square error of approximation (RMSEA ≤ 0.08), and standardized root mean square residual (SRMR ≤ 0.08) [25]. A standardized regression coefficient of a cross-lagged panel analysis was defined by the β value.…”

Section: Methodsmentioning

confidence: 99%

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A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project

et al. 2020

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Introduction: The causal relationship between sleep disorder and frequency of nocturia remains unclear. Methods: We longitudinally evaluated sleep disorder and frequency of nocturia in 547 community-dwelling adults between baseline and 5-year follow-up. We included participants ≥50 years old who have no sleep disorder (the Pittsburgh Sleep Quality Index [PSQI] ≥ 5) nor nocturia (≥1). For 5 years, we evaluated the temporal changes in sleep disorder and nocturia and the bidirectional relationships between sleep disorder and nocturia. Results: Of the 547 participants, we included 268 adults with a median age of 61 years in this study. Median PSQI and nocturia were significantly increased for 5 years from 2 to 3 and from 1 to 2, respectively. New onset of sleep disorder (PSQI > 5) and nocturia >1 was observed in 42 (16%) and 137 (51%) participants, respectively. The cross-lagged panel analysis showed that the path coefficient from PSQI to nocturia (β = 0.22, p = 0.031) was significantly higher than that from nocturia to PSQI (β = 0.02, p = 0.941). Conclusions: Our longitudinal study showed the effect of sleep disorder on nocturia was significant, although nocturia may not significantly worsen sleep disorder in community-dwelling adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project

et al. 2020

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“…Recently, nocturia, which is a common lower urinary tract symptom in older people, has been found to be not only a cause of decreased quality of life, but also a risk factor for depression and death [6,7]. The causes of nocturia include global polyuria, nocturnal polyuria, bladder storage problems, and sleep disorders [15], of which the most common cause is nocturnal polyuria [2].…”

Section: Discussionmentioning

confidence: 99%

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Takezawa

Kuribayashi

Okada

et al. 2021

Preprint

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Purpose: To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction.Methods: Patients who underwent laparoscopic nephrectomy were studied prospectively. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day two and postoperative day seven. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated by multiple linear regression analysis.Results: Forty-nine patients were included. The eGFR decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg (P < 0.01) and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (P < 0.01) with nephrectomy. Multiple linear regression analysis revealed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate.Conclusion: A decrease in renal function causes an increase in the nighttime urine volume rate, mainly due to an increase in nighttime salt excretion.Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry)Date of registration: From June 1st, 2019 to October 31th 2020

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Impact of Overactive Bladder and Dry Mouth on Subjective and Comprehensive Sleep Quality in Older Adults With Nocturia

Natsume,

Shimizu,

Fujimoto

2024

Neurourology and Urodynamics

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BackgroundNocturia is among the most common and bothersome urinary tract symptoms in older adults. While sleep quality is key to nocturia management, there is little information on the impact of nocturia itself on sleep quality. We investigated the impacts of nocturia on sleep quality and quality of life and explored factors contributing to reduced sleep quality.MethodsA total of 186 men, aged 42–88 years (patients with nocturia and a control group), were evaluated using the Pittsburgh Sleep Quality Index, the Nocturia Quality‐of‐Life questionnaire, a visual analog scale measurement of dry mouth, and the Overactive Bladder Symptom Score, among other tools. Patients were graded into four categories of nocturia severity based on 3‐day frequency volume charts. Factors associated with reduced subjective and comprehensive sleep quality were investigated using multiple regression analysis.ResultsInitial undisturbed sleep duration was negatively associated with nocturia frequency. Subjective and comprehensive sleep quality, overactive bladder scores, sleep efficiency and oral dryness were significantly associated with nocturia‐related quality of life, when controlled for both age and nocturia severity. Sleep efficiency was a major predictor of reduced subjective and comprehensive sleep quality; overactive bladder scores and oral dryness were also independently significantly associated with reduced subjective and comprehensive sleep quality on multiple regression analysis, although nocturia frequency and initial undisturbed sleep duration were not.ConclusionsIt may be beneficial to conduct a comprehensive assessment for overactive bladder and dry mouth when managing nocturia in older adults with poor sleep quality.

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Longitudinal Analysis of Bidirectional Relationships between Nocturia and Depressive Symptoms: The Nagahama Study

Cited by 19 publications

References 0 publications

A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project

A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project

Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime

Impact of Overactive Bladder and Dry Mouth on Subjective and Comprehensive Sleep Quality in Older Adults With Nocturia

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