Longitudinal Approaches to the Search for the Causes of Schizophrenia: Past, Present and Future

Jones, Peter

doi:10.1007/978-3-642-47076-9_6

Cited by 13 publications

(9 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that these studies were underpowered to find an effect, as the mean difference in birth weights between groups was actually very similar to that originally reported by Lane and Albee (9). The epidemiological concept of a "population shift" did not come to attention again until recent years (14).…”

Section: Research On Low Birth Weight (1966-1970)mentioning

confidence: 88%

“…In the coming decade we may see the first reports of studies that examine precisely measured genetic and environmental causes of schizophrenia in the same population (116). However, to adequately model interactive effects involving rare environmental risk factors (such as individual obstetric complications) and genes of small effect, sample sizes of tens of thousands will be required (14). We also have to take into account the dynamic interplay between genes and environment in utero (117).…”

Section: Interactive or Subgroup Effectsmentioning

confidence: 98%

See 1 more Smart Citation

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

1,009

664

View full text Add to dashboard Cite

Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness. Lack of statistical power to measure small and interactive effects and lack of detailed information about the prenatal period are major problems with current approaches. A combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.

show abstract

Section: Research On Low Birth Weight (1966-1970)mentioning

confidence: 88%

Section: Interactive or Subgroup Effectsmentioning

confidence: 98%

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

1,009

664

View full text Add to dashboard Cite

show abstract

“…A "neuro-developmental" subtype (Castle and Murray 1991, Castle et al 1996) which is characterized by early onset, poor pre-morbid sociality, and male preponderance has been proposed. Others (Jones 1999) have put forward the view that developmental abnormalities may be more widespread, the majority being hidden within the wide range of normal variation in the population. Thus, a comprehensive model of schizophrenia must encompass these early manifestations of dysfunction as well as the immediate pre-morbid and post-morbid period, and gender.…”

Section: Scholastic Performancementioning

confidence: 99%

Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 Birth Cohort – a descriptive life-span model

Isohanni

Jones

Kemppainen

et al. 2000

European Archives of Psychiatry and Clinical Neurosciences

View full text Add to dashboard Cite

Subtle motor, emotional, cognitive and behavioral abnormalities are often present in apparently healthy children and adolescents who later develop schizophrenia. This suggests that some aspects of causation are established long before psychosis is manifest. We aim to develop a descriptive model of the factors contributing to the development of schizophrenia. Our main focus is on genetic factors, pregnancy and delivery complications, early development and scholastic performance. This is done by reviewing the Northern Finland 1966 Birth Cohort, its scientific activities (publications and work in progress) and selected literature.

show abstract

“…Central to this hypothesis is the identification of developmental deficits preceding overt clinical symptoms of adult schizophrenia. [4][5][6] In this study, we apply a life-course approach to the study of schizophrenia and focus on developmental risk factors in early life Several different research strategies have been used to examine the developmental precursors of adult schizophrenia, including the use of archived infor-mation, follow-up studies of existing birth cohorts, and genetic high-risk studies that follow offspring of an affected parent throughout childhood and adolescence. Such strategies have uncovered robust evidence for childhood motor, language, cognitive, and behavioral precursors to schizophrenia [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] but there are 3 caveats.…”

mentioning

confidence: 99%