Longitudinal Changes in Choroidal and Retinal Thicknesses in Children With Myopic Shift

Jin, Peiyao; Zou, Haidong; Xu, Xun; Chang, Ta Chen; Zhu, Jianfeng; Deng, Junjie; Lv, Minzhi; Jin, Jiali; Sun, Sifei; Ling, Wang; He, Xiangui

doi:10.1097/iae.0000000000002090

Cited by 86 publications

(81 citation statements)

References 22 publications

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“…Interestingly, this study also found a significant relationship between the baseline choroidal thickness and the rate of eye growth, with a thicker choroid at baseline being associated with a slower rate of axial eye growth. More recently, a significant thinning of the choroid over time (mean change of 11 μm) was also reported over a 12‐month period, in 88 Chinese school children with a documented myopic shift in refraction of > 0.50 D . This population at baseline included myopic, emmetropic and hyperopic children, indicating that choroidal thinning is a feature observed in myopia progression, as well as in emmetropic children who are developing myopia.…”

Section: Choroidal Changes In Myopiamentioning

confidence: 69%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

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Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.

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Section: Choroidal Changes In Myopiamentioning

confidence: 69%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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“…22 The thinning of the choroid is noted early in myopic progression, and increases in AL and choroidal thinning are associated independently with myopic shift. 23 A study that evaluated the progression pattern of disc and retinal lesions in highly myopic adolescents found that progressive worsening of myopia and early-onset fundus tessellation were associated with thinner choroid. 24 Therefore, it is important to explore the associations between tilted optic discs and ChT in young myopic patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Morphologic Characteristics of Optic Disc on Choroidal Thickness in Young Myopic Patients

Chen

Yao

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…20 Additionally, a 1-year follow-up study of 118 Chinese children aged 7 to 12 years found choroidal thinning in eyes with a myopic shift in refraction, but not in eyes without such shift. 22 Consequently, the choroid appears to thicken in normallydeveloping young eyes and thin in eyes that have myopia. Our finding of a decreased thickening of the choroid in eyes that had a negative refractive development supports this association.…”

Section: Discussionmentioning

confidence: 99%

“…1,[17][18][19][20] Given this complexity, it is obvious that prospective studies are particularly valuable. [21][22][23] Previous longitudinal studies have been relatively small and mainly investigated populations with high myopia rates. 21,22 We describe changes in choroidal thickness from the age of 11 to 16 years in a prospective cohort study, and its association with baseline parameters and various aspect of ocular and systemic development during the observation period.…”

mentioning

confidence: 99%

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Hansen

Larsen

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We describe changes in choroidal thickness from age 11 to 16 years and its association with ocular biometrics and body development. METHOD. In this longitudinal, population-based observational study, choroidal thickness was measured subfoveally and 1-and 3-mm temporal thereof using enhanced depth imaging spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted for age and the time of day that the scan was performed. RESULTS. The study included 687 participants (304 boys). Median (interquartile range [IQR]) age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in choroidal thickness was 33, 27, and 11 lm at the three respective locations. The subfoveal choroid thickened less in eyes whose axial length increased more (boys, b ¼ À85 lm/mm; 95% confidence interval [CI], À104 to À66, P < 0.0001; girls, b ¼ À105 lm/mm; 95% CI, À121 to À89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11 lm/diopters [D]; 95% CI, 4.0 to 18, P ¼ 0.0022; girls, 22 lm/D; 95% CI, 16 to 27, P < 0.0001). Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner stage 4 vs. 1; À39 lm' 95% CI, À72 to À5.9, P ¼ 0.021) and who had a longer baseline axial length (b ¼ À8.6 lm/mm; 95% CI, À15 to À2.7, P ¼ 0.0043), and more in girls who grew taller (b ¼ 0.9 lm/cm; 95% CI, 0.1 to 1.7, P ¼ 0.026). CONCLUSIONS. The choroid increased in thickness from age 11 to 16 years. The increase was greater in girls with later sexual maturation and smaller in eyes that added more axial length and had a relatively negative refractive development.

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Longitudinal Changes in Choroidal and Retinal Thicknesses in Children With Myopic Shift

Cited by 86 publications

References 22 publications

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Impact of the Morphologic Characteristics of Optic Disc on Choroidal Thickness in Young Myopic Patients

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

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