Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab

Schwedt, Todd J.; Nikolova, Simona; Dumkrieger, Gina; Li, Jing; Wu, Teresa; Chong, Catherine D.

doi:10.1186/s10194-022-01526-5

Cited by 14 publications

(19 citation statements)

References 65 publications

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“…Recent MRI studies on resting-state functional connectivity and BOLD (i.e. blood-oxygen-level-dependent) measurements in response to moderately painful heat stimulation in patients treated with erenumab, showed that, in responders, there was a different response within the network elaborating pain stimuli (27). These studies are in favor of connectivity changes within the pain-related cortical areas, coherent with the therapeutic response.…”

Section: Discussionmentioning

confidence: 99%

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Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients

et al. 2023

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Background Monoclonal antibodies against calcitonin gene-related peptides (CGRP) are innovative therapies for migraine treatment. Although they are clinically effective, how anti-CGRP treatment reduces migraine attacks still remains unclear. Objective In this observational case–control study, we aimed to apply graph theory to EEG data from 20 migraine patients and 10 controls to investigate the effects of 3 months of galcanezumab on brain connectivity. Methods We analyzed EEG rhythms during black-white pattern reversal stimulation with 0.5 cycle per degree spatial frequency before (T0) galcanezumab injection, as well as after 3 months (T2). EEG recordings made 1 hour after galcanezumab administration served as the control session (T1). Patients’ connectivity patterns obtained at T0, T1 and T2 were compared with normal controls. Results We found that galcanezumab increased network integration (with a 5% significance level corrected with the false discovery rate), changing the intensity of connections between the occipital through the frontal areas. At 3 months follow up, patients with persistent high headache intensity had a minor effect on the strength of connections (evaluated using Kendall’s rank correlation test and p < 0.05). Conclusions The potent anti-nociceptive action that galcanezumab exerts at a peripheral level could restore cortical connections and possibly factors predisposing to attack onset.

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Section: Discussionmentioning

confidence: 99%

“…four frequency bands that we considered: delta (0.5-3.5 Hz), theta (4-7 Hz), alpha (8-12 Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

Section: Network Analysismentioning

confidence: 99%

Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients

et al. 2023

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“…The older age of the patients may suffer from the longer duration of migraine, together with CM and MOH, leading to changes in the brain's structure [ 18 , 19 ] and making it more difficult for the CGRP-mABs to be effective. In such cases, erenumab, which has been suggested to have the potential to improve the functional structure of the brain [ 20 ], maybe a better choice. It is also possible that those who were ineffective were already taking several medications, and they may have modified the CGRP-mABs effects.…”

Section: Discussionmentioning

confidence: 99%

Fremanezumab for Migraine Prevention in Japanese Elderly Aged Over 70 Years Old

Katsuki¹,

Kashiwagi²,

Kawamura³

et al. 2023

Cureus

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BackgroundElderly migraine is a public health problem with prolonged life expectancy, and effective prophylactic treatment is needed. There were no reports on fremanezumab for the elderly. We described the real-world data of fremanezumab, calcitonin gene-related peptide-related monoclonal antibody (CGRP-mAB), for migraine in elderly over 70 years old. MethodsWe retrospectively investigated six elderly migraine patients over 70 years old treated with fremanezumab. Headache impact test-6 (HIT-6), monthly headache days (MHD), and monthly acute medication intake days (AMD) before one and three months after starting fremanezumab treatment were evaluated. ResultsThree women and three men (median age 78; range: 71-99) were included. One was chronic migraine (CM), three were CM and medication-overuse headache, and two were episodic migraine and tension-type headache. All six patients received monthly fremanezumab. The median MHD before, during one, and three months after treatment were 30 (4-30), 30 (4-30), and 29 (15-30, n=4). Those of AMD were 17 (0-30), 9.5 (0-30), and 1 (0-28). Those about HIT-6 were 64 (56-72), 59.5 (52-70), and 55. 5 (48-64). Two (33.3%) of the six patients experienced therapeutic effectiveness. There were no side effects. ConclusionWe described the six elderly migraine patients aged over 70 years old treated with fremanezumab. Two (33.3%) of the six patients experienced therapeutic effectiveness. This is the first report of fremanezumab for elderly migraine patients aged over 70 years old. Further evidence accumulation is needed about CGRP-mABs for the elderly.

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“…The structural and functional properties of graphs of brain networks can be quantitatively investigated through measures of [ 239 ]: Functional segregation, e.g., clustering coefficients [ 248 , 249 , 250 , 251 , 252 ] and modularity [ 253 ]. Functional integration, based on the concept of path [ 248 , 254 ] and estimating the ease of communication between brain areas.…”

Section: Functional Connectivity Estimation Approachesmentioning

confidence: 99%

“…Functional segregation, e.g., clustering coefficients [ 248 , 249 , 250 , 251 , 252 ] and modularity [ 253 ].…”

Section: Functional Connectivity Estimation Approachesmentioning

confidence: 99%

Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends

et al. 2023

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Understanding how different areas of the human brain communicate with each other is a crucial issue in neuroscience. The concepts of structural, functional and effective connectivity have been widely exploited to describe the human connectome, consisting of brain networks, their structural connections and functional interactions. Despite high-spatial-resolution imaging techniques such as functional magnetic resonance imaging (fMRI) being widely used to map this complex network of multiple interactions, electroencephalographic (EEG) recordings claim high temporal resolution and are thus perfectly suitable to describe either spatially distributed and temporally dynamic patterns of neural activation and connectivity. In this work, we provide a technical account and a categorization of the most-used data-driven approaches to assess brain-functional connectivity, intended as the study of the statistical dependencies between the recorded EEG signals. Different pairwise and multivariate, as well as directed and non-directed connectivity metrics are discussed with a pros–cons approach, in the time, frequency, and information-theoretic domains. The establishment of conceptual and mathematical relationships between metrics from these three frameworks, and the discussion of novel methodological approaches, will allow the reader to go deep into the problem of inferring functional connectivity in complex networks. Furthermore, emerging trends for the description of extended forms of connectivity (e.g., high-order interactions) are also discussed, along with graph-theory tools exploring the topological properties of the network of connections provided by the proposed metrics. Applications to EEG data are reviewed. In addition, the importance of source localization, and the impacts of signal acquisition and pre-processing techniques (e.g., filtering, source localization, and artifact rejection) on the connectivity estimates are recognized and discussed. By going through this review, the reader could delve deeply into the entire process of EEG pre-processing and analysis for the study of brain functional connectivity and learning, thereby exploiting novel methodologies and approaches to the problem of inferring connectivity within complex networks.

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Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab

Cited by 14 publications

References 65 publications

Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients

Galcanezumab treatment changes visual related EEG connectivity patterns in migraine patients

Fremanezumab for Migraine Prevention in Japanese Elderly Aged Over 70 Years Old

Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends

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