Longitudinal Changes in Glucose Metabolism of Denervated Muscle after Complete Peripheral Nerve Injury

Pak, Kyoungjune; Shin, Myung Jun; Hwang, Sung-Jun; Shin, Jin-Hong; Shin, Hwa Kyoung; Kim, Seong Jang; Kim, In Joo

doi:10.1007/s11307-016-0948-7

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…It is well known that PNI-derived denervation leads to myoatrophy in the target muscles. Once regenerating axons reach and reinnervate the target muscles, myoatrophy can be reversed (Pak et al, 2016). Here, we performed histomorphometry on the gastrocnemius muscle and found larger myofibers in the AA-treated animals compared with those in the saline-treated control animals.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Fan

et al. 2019

Front. Cell. Neurosci.

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Ascorbic acid (AA) is an essential micronutrient that has been safely used in the clinic for many years. The present study indicates that AA has an unexpected function in facilitating nerve regeneration. Using a mouse model of sciatic nerve crush injury, we found that AA can significantly accelerate axonal regrowth in the early stage [3 days post-injury (dpi)], a finding that was revealed by immunostaining and Western blotting for antibodies against GAP-43 and SCG10. On day 28 post-injury, histomorphometric assessments demonstrated that AA treatment increased the density, size, and remyelination of regenerated axons in the injured nerve and alleviated myoatrophy in the gastrocnemius. Moreover, the results from various behavioral tests and electrophysiological assays revealed that nerve injury-derived functional defects in motor and sensory behavior as well as in nerve conduction were significantly attenuated by treatment with AA. The potential mechanisms of AA in nerve regeneration were further explored by investigating the effects of AA on three types of cells involved in this process [neurons, Schwann cells (SCs) and macrophages] through a series of experiments. Overall, the data illustrated that AA treatment in cultured dorsal root ganglionic neurons resulted in increased neurite growth and lower expression of RhoA, which is an important inhibitory factor in neural regeneration. In SCs, proliferation, phagocytosis, and neurotrophin expression were all enhanced by AA. Meanwhile, AA treatment also improved proliferation, migration, phagocytosis, and anti-inflammatory polarization in macrophages. In conclusion, this study demonstrated that treatment with AA can promote the morphological and functional recovery of injured peripheral nerves and that this effect is potentially due to AA’s bioeffects on neurons, SCs and macrophages, three of most important types of cells involved in nerve injury and regeneration.

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Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Fan

et al. 2019

Front. Cell. Neurosci.

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“…These findings are in line with those in previous studies, although LNRmean values in this study were smaller than those in former reports. In rat models of complete sciatic nerve injury, the denervated muscles showed about 5 to 10‐times higher uptake than contralateral muscles in FDG‐PET . In a human case series of patients with spinal accessory neuropathy, their denervated trapezius muscles showed about 2 to 3‐times higher mean uptake than the unaffected side in FDG‐PET .…”

Section: Discussionmentioning

confidence: 93%

¹⁸F‐FDG uptake in denervated muscles of patients with peripheral nerve injury

Choi

Seo

et al. 2019

Ann Clin Transl Neurol

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Objective: We aimed to investigate the clinical significance of increased uptake in 18 F-fluorodeoxyglucose positron emission tomography in patients with peripheral nerve lesions. Methods: We selected patients with unilateral peripheral nerve lesions confirmed with electromyography who had undergone 18 Ffluorodeoxyglucose positron emission tomography covering the lesions. In the denervated muscles and their contralateral corresponding pairs, a mean (SUVmean) and maximum standardized uptake value (SUVmax) were obtained from 18 F-fluorodeoxyglucose positron emission tomography images. We analyzed the difference in these values between the denervated and normal muscles. The lesion-to-normal ratio of the SUVmean (LNRmean) between each muscle pair was also obtained. Subgroup analysis was performed to find whether these three parameters were related to severity, abundance of abnormal spontaneous activity, and etiology. Results: Twenty-three patients with 38 denervated muscles were included. Compared to their normal counterparts, the denervated muscles showed significantly higher SUVmax (1.33 AE 0.49 vs. 1.10 AE 0.37, n = 38, P < 0.001) and SUVmean (0.91 AE 0.31 vs. 0.77 AE 0.28, n = 38, P < 0.001). The muscles with severe neuropathy showed significantly higher LNRmean than those with mild neuropathy (1.30 AE 0.36, n = 19 vs. 1.11 AE 0.24, n = 19; P = 0.046), and the muscles with traumatic neuropathy showed significantly higher LNRmean than those with nontraumatic neuropathy (1.32 AE 0.28, n = 13 vs. 1.14 AE 0.33, n = 23; P = 0.015). Interpretation: Denervated muscles with peripheral nerve injury showed higher uptake than normal muscles in 18 Ffluorodeoxyglucose positron emission tomography, and this was associated with severity and etiology.

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“…It is well known that nerve injury results in the denervation of target muscles, and furthermore, the denervation leads ultimately to muscle atrophy. 20 The muscle atrophy and the collagenous fibrosis of the gastrocnemius muscle can be reversed by gradual functional recovery of sciatic nerve. 21,22 The gastrocnemius muscles were taken out from both the injured and uninjured sides, and the wet weights of the muscles were measured.…”

Section: Examination Of the Gastrocnemius Musclementioning

confidence: 99%

Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury

Yao

Cui²,

Zhao

et al. 2017

J Biomed Mater Res

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The research on artificial nerve conduits has become a focus of study in peripheral nerve reconstruction so as a possible replacement for the treatment of autologous nerve grafts in clinics. In this study, we used longitudinally oriented collagen conduit (LOCC) combined with nerve growth factor (NGF) to reconstruct long distance of sciatic nerve defects (35 mm) in adult dog model. The long term follow-up evaluation demonstrated that the LOCC/NGF conduit allowed functional and morphological nerve regeneration at the transection site of the injured sciatic nerve. Furthermore, the functional study confirmed that when NGF was loaded onto LOCC it promoted a better recovery of regenerated axons than LOCC alone. The gastrocnemius muscle mass in the LOCC/NGF group was significantly greater than in the LOCC alone group. The results indicated that when LOCC conduit combined with NGF it would provide a preferential environment for sciatic nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2131-2139, 2018.

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Longitudinal Changes in Glucose Metabolism of Denervated Muscle after Complete Peripheral Nerve Injury

Cited by 16 publications

References 28 publications

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

¹⁸F‐FDG uptake in denervated muscles of patients with peripheral nerve injury

Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury

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Longitudinal Changes in Glucose Metabolism of Denervated Muscle after Complete Peripheral Nerve Injury

Cited by 16 publications

References 28 publications

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

18F‐FDG uptake in denervated muscles of patients with peripheral nerve injury

Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury

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Product

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¹⁸F‐FDG uptake in denervated muscles of patients with peripheral nerve injury