Longitudinal changes in optic disc topography of adult patients after trabeculectomy11The authors have no proprietary interest in any of the materials used in this study.

Topouzis, Fotis; Peng, Frank; Kotas-Neumann, Ronit; Garcia, Rudy; Sanguinet, Jackie; Yu, Fei; Coleman, Anne L.

doi:10.1016/s0161-6420(99)90248-8

Cited by 52 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduction of IOP seemed to be the most influencing parameter. 24 This phenomenon could also be observed using SD-OCT derived parameters.…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes

Koenig¹,

Hirneiß²

2021

OPTH

View full text Add to dashboard Cite

Purpose Lowering the intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) with filtration surgery can induce morphological changes to the bulbus and structures of the retina. In this study, we have evaluated changes of Bruch’s membrane-based parameters and retinal nerve fiber layer (RNFL) derived by spectral-domain optical coherence tomography (SD-OCT) in eyes that have undergone glaucoma filtration surgery. Patients and Methods SD-OCT imaging of the optic nerve head (ONH) and of the RNFL was performed in 54 eyes of 54 patients with medically uncontrolled POAG before and after IOP-lowering surgery (trabeculectomy or deep sclerectomy). The ONH parameter minimum rim width (MRW) and the size of the Bruch’s membrane opening (BMO-Area) were derived from 24 radial B-scans centered on the ONH. Results The average preoperative IOP was 23.1 ± 7.5 mmHg. One month postoperatively, the average IOP decreased to 12.1 ± 4.6 mmHg (p < 0.01), which caused a significant increase in the thickness of neuroretinal rim. There was no significant change in the automatically detected BMO-Area (p = 0.32). The pressure-related increase in MRW correlated well with the postoperative IOP and cup-to-disc ratio (CDR). In regression analysis, the alteration in thickness of the neuroretinal rim could be well predicted in a model including CDR, change of IOP and mean deviation (MD) (R 2 = 0.414, p < 0.001). RNFL showed a significant increase as well. Conclusion IOP-lowering surgery in patients with medically uncontrolled POAG causes an increased thickness of the SD-OCT derived ONH parameters. The changes of the RNFL after surgery showed no significant correlations with IOP changes. In contrast to this, highly significant correlations of MRW values with the IOP could be observed. The BMO-Area remained completely stable A preferred use of RNFL for follow-up should be discussed.

show abstract

“…The reduction of IOP seemed to be the most influencing parameter. 24 This phenomenon could also be observed using SD-OCT derived parameters.…”

Section: Discussionmentioning

confidence: 71%

“…The reduction of IOP seemed to be the most influencing parameter. 24 This phenomenon could also be observed using SD-OCT derived parameters. BMO-Area is known to be larger in size in glaucoma patients than compared to healthy individuals.…”

Section: Discussionmentioning

confidence: 71%

Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes

Koenig¹,

Hirneiß²

2021

OPTH

View full text Add to dashboard Cite

show abstract

“…Topouzis et al[13] did not find any significant changes in optic nerve head (ONH) parameters 8 months after surgery. This result might be due to the high degree of pre-existing glaucomatous damage (MD, -13.2 dB), because experimental studies[141516] have shown that reversal of damage is more likely to occur in earlier stages of glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomographic assessment of retinal nerve fiber layer thickness changes before and after glaucoma filtration surgery

Sarkar¹,

Das²,

Ranabir³

et al. 2014

Oman J Ophthalmol

View full text Add to dashboard Cite

Background: Glaucomatous Optic Neuropathy (GON) is very common in the glaucoma patients, and impaired effect of glaucoma is measured by the Retinal Nerve Fiber Layer (RNFL) thickness.Objective: The study was conducted to find out the mean RNFL thickness, RNFL thickness in different quadrants, Intra-Ocular Pressure (IOP) changes, and visual field changes after filtration surgery in different ages and genders using Optical Coherence Tomography (OCT).Materials and Methods:The study was an interventional case-series conducted at the Glaucoma Clinic at the Regional Institute of Ophthalmology at Kolkata from March 2009 to August 2010. Fifty-one eyes of 43 open angle glaucoma patients had been selected for clinical and ophthalmologic evaluation. All the eyes of glaucoma patients who fulfilled the inclusion criteria were registered in the study population. The glaucoma filtration surgery was done in these patients. The RNFL thickness, IOP, visual field changes were measured before and after intervention of filtration surgery. Pre-operative OCT images of RNFL were obtained 0 to 120 days before surgery, and post-operative images were obtained from 60 to 120 days after surgery. Data collected in a standard data collection form included schedule.Results: Paired t-test was used. RNFL thickness was (pre-operative: 52.56 ± 17.40, post-operative: 58.48 ± 20.20, P < 0.0001) significantly increased after filtration surgery measured by OCT with significant reduction of IOP (r = - 0.38, P = 0.005) irrespective of age and gender.Conclusions: An increase in RNFL thickness was observed after glaucoma filtration surgery that correlated with IOP reduction.

show abstract

“…It has been suggested that as IOP rises the accompanying mechanical responses of the tissues around the lamina cribrosa compress the vein, and outflow resistance is increased 1,5,9 . This theory is supported by the observations that variation in IOP causes movement of the optic disc 11 and lamina cribrosa, 12 and that reversal of cupping is seen following trabeculectomy 13,14 …”

Section: Discussionmentioning

confidence: 93%

A pilot study of in vivo venous pressures in the pig retinal circulation

Westlake

Morgan

2001

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Retinal venous pressure was examined in six pigs using a balanced servo-nulling micropuncture technique. The mean transmural venous pressure was 0.95 mmHg (SD 1.50 mmHg). The transmural venous pressure was lower at the optic disc than away from the disc (0.32 +/- 1.46 mmHg vs 1.69 +/- 1.19 mmHg, P < 0.01). At the disc a transmural pressure of zero or less (0 to -0.5 mmHg) was demonstrated in 10/21 (48%) of the disc readings. Over an intraocular pressure range of 15-26 mmHg there was a strong correlation between intraocular pressure and retinal venous pressure (Pearson coefficient r = 0.92). The results are compatible with the Starling resistor theory of venous outflow from the eye.

show abstract

Longitudinal changes in optic disc topography of adult patients after trabeculectomy11The authors have no proprietary interest in any of the materials used in this study.

Cited by 52 publications

References 17 publications

Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes

Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes

Optical coherence tomographic assessment of retinal nerve fiber layer thickness changes before and after glaucoma filtration surgery

A pilot study of in vivo venous pressures in the pig retinal circulation

Contact Info

Product

Resources

About