Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic‐bomb survivors

Yoshida, Kengo; Misumi, Munechika; Kusunoki, Yoichiro; Yamada, Michiko

doi:10.1111/bjh.17296

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Most mutations exhibited characteristics of radiation-induced molecular changes, clearly demonstrating that radiation exposure induces the development of CH-associated mutations in mice; CH expansion is difficult to analyze in mice because of their short lifespan 24 . In addition, 3 Gy-irradiated mice exhibited radiation-associated increases in both their peripheral blood myeloid cell numbers and RDW values, which are often observed in survivors exposed to atomic-bomb radiation and in humans with CH 1 , 8 , 28 .…”

Section: Discussionmentioning

confidence: 92%

“…CH-associated gene mutations are involved in the pathogenesis of CVD 34 , and higher VAFs, typically > 0.1, in CH cases are closely associated with increased morbidity and mortality 35 . Increases in blood myeloid cell numbers and RDW are also strong predictors of prognosis and mortality due to various diseases, including cancer and CVD 23 , and have been observed in atomic-bomb survivors 8 , 28 . However, there was no significant association between VAFs of CH-associated mutations and these blood markers in the irradiated mice examined in this study.…”

Section: Discussionmentioning

confidence: 99%

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Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation

Yoshida

Satoh

Uchimura

et al. 2022

Sci Rep

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Clonal hematopoiesis (CH) is prevalent in the elderly and associates with hematologic malignancy and cardiovascular disease. Although the risk of developing these diseases increases with radiation doses in atomic-bomb survivors, the causal relationship between radiation exposure and CH is unclear. This study investigated whether radiation exposure induces CH in mice 12–18 months after 3-Gy whole-body irradiation. We found radiation-associated increases in peripheral blood myeloid cells and red blood cell distribution width (RDW). Deep sequencing of bone marrow and non-hematopoietic tissue cells revealed recurrent somatic mutations specifically in the hematopoietic system in 11 of 12 irradiated mice but none in 6 non-irradiated mice. The irradiated mice possessed mutations with variant allele frequencies (VAFs) of > 0.02 on an average of 5.8 per mouse; mutations with VAFs of > 0.1 and/or deletion were prevalent. Examining hematopoietic stem/progenitor cells in two irradiated mice revealed several mutations co-existing in the same clones and multiple independent clones that deliver 60–80% of bone marrow nuclear cells. Our results indicate development of massive CH due to radiation exposure. Moreover, we have characterized mutations in radiation-induced CH.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation

Yoshida

Satoh

Uchimura

et al. 2022

Sci Rep

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“…10 Moreover, any other factor such as toxic substances, chemotherapeutic agents, radiation, and other drugs impacting the bone marrow stem cells' life cycle, may increase the RDW. [11][12][13] Obesity and metabolic syndrome which are well-known causes of chronic lowgrade systemic inflammation are also associated with higher RDW. 14 Apart from abnormal erythropoiesis, any factor causing RBC fragmentation in peripheral blood could raise the RDW.…”

Section: The Mechanistic Link Between Rdw and Cardiovascular Disordersmentioning

confidence: 99%

Is Red Cell Distribution Width a Reliable Marker for Cardiovascular Diseases? A Narrative Review

Heshmat-Ghahdarijani

Fakhrolmobasheri

2022

Cardiology in Review

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Red cell distribution width (RDW) is an easy-to-access marker which is routinely measured in complete blood count (CBC) test. Besides the classic use of RDW as a marker for discriminating different types of anemia, recent studies had indicated the relationship between high RDW and cardiovascular diseases. High RDW is not only useful in the diagnosis and prognostication of various cardiovascular conditions but also could be used as a valuable tool for predicting the incidence of cardiovascular diseases. population-based studies have indicated that higher RDW could effectively predict the incidence of heart failure (HF), atherosclerotic diseases, and atrial fibrillation (AF). It has been also demonstrated that higher RDW is associated with worse outcomes in these diseases. Recent studies have shown that high RDW is also associated with other cardiovascular conditions including cardiomyopathies, and pulmonary hypertension. The predictive role of RDW in endovascular interventions has also been demonstrated by many recent studies.Here in this review, we attempt to compile the most recent findings with older reports regarding the relation between high RDW and HF, cardiomyopathies, pulmonary hypertension, AF, atherosclerotic disorders, primary hypertension, and the outcomes of endovascular interventions. we also discussed the role of RDW in the prognostication of different cardiovascular conditions when combined with classic classification criteria.

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High variability in short and long-term recovery kinetic of blood cell count and blood chemistry in a partial body irradiation mouse model

Tang,

Zawaski,

Sabek

et al. 2024

International Journal of Radiation Biology

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Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic‐bomb survivors

Cited by 3 publications

References 15 publications

Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation

Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation

Is Red Cell Distribution Width a Reliable Marker for Cardiovascular Diseases? A Narrative Review

High variability in short and long-term recovery kinetic of blood cell count and blood chemistry in a partial body irradiation mouse model

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