2016
DOI: 10.3341/kjo.2016.30.2.114
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Longitudinal Changes in Retinal Nerve Fiber Layer Thickness after Intravitreal Anti-vascular Endothelial Growth Factor Therapy

Abstract: PurposeTo determine the effects of intravitreal anti-vascular endothelial growth factor (VEGF) on thickness of the retinal nerve fiber layer (RNFL) in patients with age-related macular degeneration.MethodsTwenty eyes of 20 patients diagnosed with age-related macular degeneration who underwent intravitreal anti-VEGF injection were studied. Postinjection RNFL thickness was measured using optical coherence tomography. Average thickness, four-quadrant RNFL thicknesses, and intraocular pressure (IOP) in affected ey… Show more

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Cited by 23 publications
(15 citation statements)
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“…1; Supplementary Table S1). The literature search for studies investigating RNFLthickness yielded a total of 11 eligible articles 58,86,[96][97][98][99][100][101][102][103] , of which 9 were eligible for meta-analyses ( Fig. 1; Supplementary Table S1).…”
Section: Resultsmentioning
confidence: 99%
“…1; Supplementary Table S1). The literature search for studies investigating RNFLthickness yielded a total of 11 eligible articles 58,86,[96][97][98][99][100][101][102][103] , of which 9 were eligible for meta-analyses ( Fig. 1; Supplementary Table S1).…”
Section: Resultsmentioning
confidence: 99%
“…In both groups, the pRNFL thickness in the affected eye decreased as the CMT decreased. In this regard, a previous study including patients with diabetic retinopathy and age-related macular degeneration reported that the pRNFL was affected by macular lesions 27 , 28 . Macular edema due to RVO is known to involve the inner layers of retina, as compared to diabetic macular edema 29 .…”
Section: Discussionmentioning
confidence: 95%
“…This study demonstrates that, in the presence of macular edema, specific topographic changes of the macular RNFL occur secondary to active compressional strain from the macular cysts on the overlying RNFL. The focal nature of this phenomenon within the macula may explain previously reported inconsistent findings in studies in which correlation of macular edema with peripapillary, 32,33 rather than macular 34,35 RNFL thickness was sought. The absence of similar RNFL changes in nonedematous portions of the macula or in the fellow eye indicate that these changes are neither due to anti-VEGF injections nor to underlying retinal vascular diseases, nor a systemic vasculopathy.…”
Section: Discussionmentioning
confidence: 95%