2016
DOI: 10.1167/iovs.15-19005
|View full text |Cite
|
Sign up to set email alerts
|

Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation

Abstract: Citation: Downie LE, Choi J, Lim JKH, Chinnery HR. Longitudinal changes to tight junction expression and endothelial cell integrity in a mouse model of sterile corneal inflammation. Invest Ophthalmol Vis Sci. 2016;57:3477-3484. DOI:10.1167/iovs.15-19005 PURPOSE. We previously reported that applying toll-like receptor (TLR) ligands to an injured cornea induces corneal edema at 24 hours, which subsides by 1 week. We tested the hypotheses that endothelial expression of the tight-junction protein, zonula occlud… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
6
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 10 publications
(6 citation statements)
references
References 34 publications
0
6
0
Order By: Relevance
“…In a follow‐up study, the chronic pathological changes induced by topical application of the TLR9 ligand, CpG‐DNA, to the injured mouse cornea was clinically assessed using SD‐OCT. In these studies, elevated corneal thickness was associated with reduced endothelial cell density and morphology, and the presence of giant macrophages in the corneal stroma, four weeks post‐treatment …”
Section: As‐oct Imaging In Animalsmentioning
confidence: 90%
See 3 more Smart Citations
“…In a follow‐up study, the chronic pathological changes induced by topical application of the TLR9 ligand, CpG‐DNA, to the injured mouse cornea was clinically assessed using SD‐OCT. In these studies, elevated corneal thickness was associated with reduced endothelial cell density and morphology, and the presence of giant macrophages in the corneal stroma, four weeks post‐treatment …”
Section: As‐oct Imaging In Animalsmentioning
confidence: 90%
“…In a mouse model of sterile inflammation caused by topical application of endotoxin or CpG‐DNA, corneal oedema, endothelial inflammatory cells (keratic precipitates), anterior chamber cells, and stromal opacities were longitudinally monitored . In these studies, the differences in strain responses were striking, with the corneas of C57BL/6 J mice appearing to have fully recovered by seven days post‐injury, whereas BALB/c mice exhibited signs of ongoing inflammation (corneal opacity and oedema) at the same time point …”
Section: As‐oct Imaging In Animalsmentioning
confidence: 99%
See 2 more Smart Citations
“…To induce the nerve injury, a 2 mm trephine was used to mark the central cornea and the epithelium within this zone was debrided using a corneal rust ring remover (Algerbrush II; Alger Equipment Co., Lago Vista, TX, USA). 39 , 40 To prevent dryness of the ocular surface, a 2 µL drop of sterile saline was applied. After one week, the mice were euthanized by lethal injection of Lethabarb (100 mg/kg, intraperitoneal; Lyppard, Keysborough, VIC, Australia).…”
Section: Methodsmentioning
confidence: 99%