Longitudinal Characteristics of Lymphocyte Responses and Cytokine Profiles in the Peripheral Blood of SARS-CoV-2 Infected Patients

Liu, Jing; Li, Sumeng; Liang, Boyun; Wang, Xiaobei; Li, Wei; Wang, Hua; Tong, Qiaoxia; Yi, Jianhua; Zhao, Lei; Xiong, Lijuan; Guo, Chunmei; Jin, Tian; Luo, Jing; Yao, Jinghong; Pang, Ran; Shen, Hui; Peng, Cheng; Liu, Ting; Zhang, Qian; Wu, Jun; Xu, Ling; Lu, Sihong; Wang, Baoju; Weng, Zhihong; Han, Caixia; Zhu, Huabing; Zhou, Ruxia; Zhou, Haoran; Chen, Xiliu; Ye, Pian; Zhu, Bin; He, Shengsong; He, Yueqiu; Shen, Jie; Wei, Ping; Zhang, Jianao; Lu, Yinping; Wang, Weixian; Zhang, Li; Li, Ling; Zhou, Fangyuan; Wang, Jun; Dittmer, Ulf; Lu, Mengji; Hu, Yu; Yang, Dongliang; Zheng, Xin

doi:10.2139/ssrn.3539682

Cited by 409 publications

(645 citation statements)

References 6 publications

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“…These results suggested that the liver injury occurred in COVID‐19 patients may be due to the damage to bile duct cells, but not liver cells by the virus infection. Besides, the inflammatory cytokine storm was observed in severe COVID‐19 cases, 55 yet whether it results in liver damage in patients remains to be investigated. Postmortem biopsies were recently performed in a death COVID‐19 patient, and the results showed moderate microvascular steatosis and mild lobular and portal activity, indicating the injury could have been caused by either SARS‐CoV‐2 infection or drug‐induced liver injury 56 .…”

Section: Sars‐cov‐2 and Liver Injurymentioning

confidence: 99%

Liver injury during highly pathogenic human coronavirus infections

Liu

et al. 2020

Liver International

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776

836

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The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019 novel coronavirus disease (COVID‐19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS‐CoV‐2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS‐CoV‐2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus – severe acute respiratory syndrome coronavirus (SARS‐CoV) and the Middle East respiratory syndrome coronavirus (MERS‐CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS‐CoV, MERS‐CoV as well as SARS‐CoV‐2 infection were summarized, which may provide help for further studies on the liver injury of COVID‐19.

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Section: Sars‐cov‐2 and Liver Injurymentioning

confidence: 99%

Liver injury during highly pathogenic human coronavirus infections

Liu

et al. 2020

Liver International

Self Cite

776

836

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“…Several possible mechanisms are indicated as below. Immune mediated damage as a result of the severe inflammatory response following COVID‐19 infection 6 : the inflammation biomarkers including C reactive protein (CRP), serum ferritin, LDH, D‐dimer, IL‐6, IL‐2, were significant elevated in severe patients with COVID‐19 16 Direct cytotoxicity as a result of active viral replication in hepatic cells: SARS‐CoV‐2 binds to target cells through ACE2.…”

Section: Mechanisms Of Liver Injurymentioning

confidence: 99%

COVID‐19 and liver disease

Sun

Aghemo

Forner

et al. 2020

Liver International

302

318

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“…The disruption of endothelial lining initiates a vicious cycle of tissue damage due to the in ammatory response facilitated by the accumulation of regional macrophages, neutrophils, and lymphocytes, resulting in "cytokine storm." Subsequent multiorgan failure because of direct viral replication in other organs and the systemic "cytokine storm" lead to hypoxemic respiratory failure, acute respiratory distress syndrome, and sepsis (4,7).…”

Section: Introductionmentioning

confidence: 99%

Perspectives on the Early Quality of Evidence Guiding the Therapeutic Management of SARS CoV-2: A Systematic Literature Review

Subramanian¹,

Nalli²,

Senthil³

et al. 2020

Preprint

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Abstract Background:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a serious health concern. Repurposing of existing drugs indicated for other conditions seems to be the first choice for immediate therapeutic management. The quality of early evidence favoring the different treatment options needs to be apprised for informed decision making. Methods:In this systematic literature review, we apprised the quality of available evidence for different therapeutic options and also the basis for different treatment guidelines. In order to include all studies that are in different stages of publications, we also included studies from the preprint servers, BioRxiv, MedRxiv and published studies from PubMed. Results:We retrieved 5621 articles and included 20 studies for the systematic review. Based on our study, chloroquine/hydroxychloroquine either alone or in combination with azithromycin, remdesivir, corticosteroids, convalescent sera, ritonavir/lopinavir and arbidol were evaluated as therapeutic options. The data from different study designs reveal contradictory findings except for convalescent sera for which the evidence available is only from case series. Based on these early evidence, various national guidelines recommend remdesivir, convalescent sera, corticosteroids, hydroxychloroquine in different sub set of patients. Conclusion:Establishing consensus with respect to the endpoints to be assessed for respiratory viruses may enhance the quality of evidences in case of future pandemics. Further clinical evidence from the ongoing trials may lead to evolution of treatment guidelines with the addition of more therapeutic options.

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Longitudinal Characteristics of Lymphocyte Responses and Cytokine Profiles in the Peripheral Blood of SARS-CoV-2 Infected Patients

Abstract: Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients, EBioMedicine (2020), doi:

Cited by 409 publications

References 6 publications

Liver injury during highly pathogenic human coronavirus infections

Liver injury during highly pathogenic human coronavirus infections

COVID‐19 and liver disease

Perspectives on the Early Quality of Evidence Guiding the Therapeutic Management of SARS CoV-2: A Systematic Literature Review

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