Longitudinal correlative analysis of epileptic baboon, Papio papio

Wada, Juhn A.; Terao, Akira; Booker, Harold E.

doi:10.1212/wnl.22.12.1272

Cited by 57 publications

(22 citation statements)

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“…Modifications of previous protocols (Fischer-Williams et al, 1968; Wada et al, 1972; Naquet et al, 1975) included the adaptation of continuous video-EEG monitoring to record spontaneous generalized myoclonic and tonic-clonic seizures, and the implementation of a combination of subdural grid, strip and depth electrodes instead of merely depth electrodes to improve spatial resolution of ictal or interictal epileptic discharges on the cortical surface. Furthermore, cerebral blood flow (CBF) studies were utilized to generate targets for electrode placement (Szabó et al, 2007; Szabó et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

et al. 2012

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The baboon provides a natural non-human primate model for photosensitive, generalized epilepsy. This study describes an implantation procedure for the placement of subdural grid and strip electrodes for continuous video-EEG monitoring in the epileptic baboon to evaluate the generation and propagation of ictal and interictal epileptic discharges. Subdural grid, strip and depth electrodes were implanted in six baboons, targeting brain regions that were activated in functional neuroimaging studies during photoparoxysmal responses. The baboons were monitored with continuous video-EEG monitoring for 2–21 (mean 9) days. Although the animals were tethered, the EEG signal was transmitted wirelessly to optimize their mobility. Spontaneous seizures, interictal epileptic discharges (IEDs), and responses to intermittent light stimulation (ILS) were assessed. Due to cortical injuries related to the electrode implantation and their displacement, the procedure was modified. Habitual myoclonic and generalized tonic-clonic seizures were recorded in three baboons, all associated with a generalized ictal discharge, but were triggered multiregionally, in the frontal, parietal and occipital cortices. IEDs were similarly expressed multiregionally, and responsible for triggering most generalized spike-and-wave discharges. Generalized photoparoxysmal responses were activated only in one baboon, while driving responses recorded in all three photosensitive baboons were 2.5 times the stimulus rate. In contrast to previous intracranial investigations in this model, generalized ictal and interictal epileptic discharges were triggered by parietal and occipital, in addition to the frontocentral cortices. Furthermore, targeted visual areas responded differently to ILS in photosensitive than nonphotosensitive baboons, but further studies are required before mechanisms can be implicated for ILS-induced activation of the epileptic networks.

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Section: Discussionmentioning

confidence: 99%

“…Photoparoxysmal and –convulsive responses could be reliably recorded and monitored with invasive, intracerebral depth electrodes (Fischer-Williams et al, 1968; Wada et al, 1972; Naquet et al, 1975). One of the shortcomings of these earlier studies was the inability to record continuously and, hence, record spontaneous seizures.…”

Section: Introductionmentioning

confidence: 99%

Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

et al. 2012

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“…All animals underwent monthly evaluation of photosensitivity for >1 year before the start of study, according to the procedure established in our laboratory (10). Only 1 animal (W244) showed an infrequent and minimal eyelid twitching response (described herein).…”

Section: Methodsmentioning

confidence: 99%

Role of the Claustrum in Convulsive Evolution of Visual Afferent and Partial Nonconvulsive Seizure in Primates

Wada

Tsuchimochi

1997

Epilepsia

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Summary: Purpose: We tested cross-species validity of the role of the claustrum in the convulsive evolution of the visual afferent and amygdaloid seizure and the specificity of the claustral lesioning effect.Methods: In 7 Senegalese baboons, we examined the effect of unilateral claustral lesioning on generalized convulsive seizures either kindled from the amygdaloid nucleus (AM) and cingulate cortex (CG) or induced by intermittent photic stimulation (IPS) after systemic administration of D,L-allylglycine (AG).Results: A lesioned area common to all animals was the anterior half of the left claustrum. Postoperative restimulation of the kindled left AM or CG evoked only nonconvulsive seizures. When few convulsive seizures emerged in 1 CG-kindled animal, they were mirror image of the kindled seizure and arose from the nonlesioned right hemisphere. Restimulation of the kindled right AM or CG reactivated kindled seizures. An IPSinduced generalized convulsive seizure was transformed into a secondarily generalized seizure arising from the nonlesioned right hemisphere.Conclusions: The primate claustrum regulates the convulsive evolution of partial seizures originating from nonmotor structures such as the AM and CG and also regulates the convulsive development that follows IPS. Our findings suggest that predisposed susceptibility expressed at the claustrum may be involved in the clinical variation with respect to convulsive evolution of nonmotor partial seizures and convulsive susceptibility to IPS in human primates.

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“…Indeed, in the laboratory studies it was possible to determine the animals' reactivity time under ILS, which was significantly variable (Killam et al, 1967;Wada et al, 1972). However, in the field studies the average reactivity of each animal in a given population was not obtainable because of the methodology used.…”

Section: Discussionmentioning

confidence: 99%

Excessive Light Sensitivity inPap₁₀ papio: Its Variation with Age, Sex, and Geographic Origin

Balzamo¹,

Bert²,

Ménini³

et al. 1975

Epilepsia

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Excessive sensitivity (levels 3 and 4) in a population of 1,122 Papio papio was related with age, sex, and geographical origin. (1) Age. There was no clinical response to intermittent light stimulation under the age of 5 months. These was no difference between animals 6 months to 2 years (J1) and those aged 2 to 4 years (J2). Adult females were less often light sensitive (levels 3 and 4 = 32.9%) than immature females (52.4%). Adult males could usually not be tested, but were probably less often sensitive than immature males. (2) Sex. Immature females (J1 + J2) were more often light sensitive (52.4%) than immature males (38.1%). (3) Geographical origin. No animals from East Senegal (Sansande Region) were very light sensitive. Animals from Casamance were more often light sensitive (56.2%) than those from the Niokolo-Koba National Park (N.K.N.P.) (20%). Of two samples taken at one spot between these two regions, one group resembled the population from Casamance and the second resembled that from the N.K.N.P. This observation raises several questions about the respective roles of genetic, ecological, and ethological factors.

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Longitudinal correlative analysis of epileptic baboon, Papio papio

Cited by 57 publications

References 0 publications

Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

Role of the Claustrum in Convulsive Evolution of Visual Afferent and Partial Nonconvulsive Seizure in Primates

Excessive Light Sensitivity inPap₁₀ papio: Its Variation with Age, Sex, and Geographic Origin

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Longitudinal correlative analysis of epileptic baboon, Papio papio

Cited by 57 publications

References 0 publications

Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

Baboon model of generalized epilepsy: Continuous intracranial video-EEG monitoring with subdural electrodes

Role of the Claustrum in Convulsive Evolution of Visual Afferent and Partial Nonconvulsive Seizure in Primates

Excessive Light Sensitivity inPap10 papio: Its Variation with Age, Sex, and Geographic Origin

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Excessive Light Sensitivity inPap₁₀ papio: Its Variation with Age, Sex, and Geographic Origin