Role of the Claustrum in Convulsive Evolution of Visual Afferent and Partial Nonconvulsive Seizure in Primates

Wada, Juhn A.; Tsuchimochi, Hirohito

doi:10.1111/j.1528-1157.1997.tb01255.x

Cited by 22 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus Kudo and Wada (1990) found that electrolytic lesions of the cat anterior claustrum ipsilateral to the kindled amygdala degraded generalized kindled seizures to partial seizures and retarded kindling. Similar results have also been observed in monkeys (Wada and Tsuchimochi, 1997). Radio-frequency (RF) lesions of the posterior claustrum delay amygdaloid kindling in rats (Mohapel et al, 2001).…”

Section: Abstract: Kindling; Epilepsy; Seizure; Claustrum; Pha-l; Flsupporting

confidence: 71%

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

et al. 2001

View full text Add to dashboard Cite

The claustrum has been implicated in the kindling of generalized seizures from limbic sites. We examined the susceptibility of the anterior claustrum itself to kindling and correlated this with an anatomical investigation of its afferent and efferent connections.Electrical stimulation of the anterior claustrum resulted in a pattern of rapid kindling with two distinct phases. Early kindling involved extremely rapid progression to bilaterally generalized seizures of short duration. With repeated daily kindling stimulations, early-phase generalized seizures abruptly became more elaborate and prolonged, resembling limbic-type seizures as triggered from the amygdala. We suggest that the rapid rate of kindling from the anterior claustrum is an indication that the claustrum is functionally close to the mechanisms of seizure generalization.In support of our hypothesis, we found significant afferent, efferent, and often reciprocal connections between the anterior claustrum and areas that have been implicated in the generation of generalized seizures, including frontal and motor cortex, limbic cortex, amygdala, and endopiriform nucleus. Additional connections were found with various other structures, including olfactory areas, nucleus accumbens, midline thalamus, and brainstem nuclei including the substantia nigra and the dorsal raphe nucleus. The anatomical connections of the anterior claustrum are consistent with its very high susceptibility to kindling and support the view that the claustrum is part of a forebrain network of structures participating in the generalization of seizures.

show abstract

Section: Abstract: Kindling; Epilepsy; Seizure; Claustrum; Pha-l; Flsupporting

confidence: 71%

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Indeed, the claustrum could be a key region in promoting the propagation and synchronization of abnormal epileptic activity from several cortical regions (12, 32). Two properties of claustrum neurons are relevant: (a) claustro-cortical fibers connect the claustrum with several cortical areas including the prefrontal, pre-postcentral, orbitofrontal, and medial temporal cortex (33, 34); (b) the claustrum is constituted by densely packed and tightly interconnected GABAergic interneurons whose damage could promote a state of hyper-synchronization and bindings of activity from several distant cortical regions (34–38). Notably, these experimental findings can account for the frequently observed presence of PD over one or both hemispheres during continuous EEG monitoring in our patients, as well as the often bi-hemispheric or independent seizure origin during the acute phase.…”

Section: Discussionmentioning

confidence: 99%

New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features

et al. 2017

View full text Add to dashboard Cite

New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign characterized by bilateral lesions of the claustrum. The group includes 31 patients (12 personal and 19 previously published cases; 17 females; mean age of 25 years). Fever preceded status epilepticus (SE) in 28 patients, by a mean of 6 days. SE was refractory/super-refractory in 74% of the patients, requiring third-line agents and a median of 15 days staying in an intensive care unit. Focal motor and tonic–clonic seizures were observed in 90%, complex partial seizures in 14%, and myoclonic seizures in 14% of the cases. All patients showed T2/FLAIR hyperintense foci in bilateral claustrum, appearing on average 10 days after SE onset. Other limbic (hippocampus, insular) alterations were present in 53% of patients. Within the personal cases, extensive search for known autoantibodies was inconclusive, though 7 of 11 patients had cerebrospinal fluid lymphocytic pleocytosis and 3 cases had oligoclonal bands. Two subjects died during the acute phase, one in the chronic phase (probable sudden unexplained death in epilepsy), and one developed a persistent vegetative state. Among survivors, 80% developed drug-resistant epilepsy. Febrile illness-related SE associated with bilateral claustrum hyperintensity on MRI represents a condition with defined clinical features and a presumed but unidentified autoimmune etiology. A better characterization of de novo SE is mandatory for the search of specific etiologies.

show abstract

“…This finding suggests that even a light projection entering these regions can be extensively distributed within the area and influence brain regions targeted by these nuclei. This might explain why the claustrum and the endopiriform nucleus are implicated as brain areas by means of which seizure activity originating in the temporal lobe can rapidly spread to various extratemporal regions (Kudo and Wada, 1990; Mohapel and Corcoran, 1996; Wada and Kudo, 1997; Wada and Tsuchimochi, 1997; Mohapel et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: A Phaseolus vulgaris leucoagglutinin study in the rat

Majak

Pikkarainen

Kemppainen

et al. 2002

J of Comparative Neurology

View full text Add to dashboard Cite

The claustrum and the endopiriform nucleus contribute to the spread of epileptiform activity from the amygdala to other brain areas. Data of the distribution of pathways underlying the information flow between these regions are, however, incomplete and controversial. To investigate the projections from the amygdala to the claustrum and the endopiriform nucleus, we injected the anterograde tracer Phaseolus vulgaris leucoagglutinin into various divisions of the amygdaloid complex, including the lateral, basal, accessory basal, central, anterior cortical and posterior cortical nuclei, the periamygdaloid cortex, and the amygdalohippocampal area in the rat. Analysis of immunohistochemically processed sections reveal that the heaviest projections to the claustrum originate in the magnocellular division of the basal nucleus. The projection is moderate in density and mainly terminates in the dorsal aspect of the anterior part of the claustrum. Light projections from the parvicellular and intermediate divisions of the basal nucleus terminate in the same region, whereas light projections from the accessory basal nucleus and the lateral division of the amygdalohippocampal area innervate the caudal part of the claustrum. The most substantial projections from the amygdala to the endopiriform nucleus originate in the lateral division of the amygdalohippocampal area. These projections terminate in the central and caudal parts of the endopiriform nucleus. Lighter projections originate in the anterior and posterior cortical nuclei, the periamygdaloid cortex, the medial division of the amygdalohippocampal area, and the accessory basal nucleus. These data provide an anatomic basis for recent functional studies demonstrating that the claustrum and the endopiriform nucleus are strategically located to synchronize and spread epileptiform activity from the amygdala to the other brain regions. These topographically organized pathways also provide a route by means of which the claustrum and the endopiriform nucleus have access to inputs from the amygdaloid networks that process emotionally significant information.

show abstract

Role of the Claustrum in Convulsive Evolution of Visual Afferent and Partial Nonconvulsive Seizure in Primates

Cited by 22 publications

References 34 publications

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

Susceptibility to Kindling and Neuronal Connections of the Anterior Claustrum

New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features

Projections from the amygdaloid complex to the claustrum and the endopiriform nucleus: A Phaseolus vulgaris leucoagglutinin study in the rat

Contact Info

Product

Resources

About