Longitudinal Diffusion Tensor Magnetic Resonance Imaging Study of Radiation-Induced White Matter Damage in a Rat Model

Wang, Silun; Wu, Ed X.; Qiu, Deqiang; Leung, LP; Lau, Ho-Fai; Khong, Pek‐Lan

doi:10.1158/0008-5472.can-08-2661

Cited by 113 publications

(114 citation statements)

References 35 publications

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“…32,33 In the posterior part of the cingulum, the means of the RD were increased by 11.4% at the end of RT (p < 0.001) and by 10.5% 1-month post-RT from pre-RT (p < 0.008), while the means in the AD were not changed significantly at both time points, suggesting the radiationinduced demyelination is predominant. Similarly, in the fornix, the means of the RD were increased by 7.1% at the end II.…”

Section: Iiic1 Longitudinal Percentage Changes In Diffusion Indicesmentioning

confidence: 98%

Radiation therapy effects on white matter fiber tracts of the limbic circuit

et al. 2012

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Purpose: To segment fiber tracts in the limbic circuit and to assess their sensitivity to radiation therapy (RT). Methods: Twelve patients with brain metastases who had received fractionated whole brain radiation therapy to 30 Gy or 37.5 Gy were included in the study. Diffusion weighted images were acquired pre-RT, at the end of RT, and 1-month post-RT. The fornix, corpus callosum, and cingulum were extracted from diffusion weighted images by combining fiber tracking and segmentation methods based upon characteristics of the fiber bundles. Cingulum was segmented by a seed-based tractography, fornix by a region of interests (ROI)-based tractography, and corpus callosum by a level-set segmentation algorithm. The radiation-induced longitudinal changes of diffusion indices of the structures were evaluated. Results: Significant decreases were observed in the fractional anisotropy of the posterior part of the cingulum, fornix, and corpus callosum from pre-RT to end of RT by -14.0%, -12.5%, and -5.2%, respectively (p < 0.001), and from pre-RT to 1-month post-RT by -11.9%, -12.8%, and -6.4%, respectively (p < 0.001). Moreover, significant increases were observed in the mean diffusivity of the corpus callosum and the posterior part of the cingulum from pre-RT to end of RT by 6.8% and 6.5%, respectively, and from pre-RT to 1-month post-RT by 8.5% and 6.3%, respectively. The increase in the radial diffusivity primarily contributed to the significant decrease in the fractional anisotropy, indicating that demyelination is the predominant radiation effect on the white matter structures. Conclusions: Our findings indicate that the fornix and the posterior part of the cingulum are significantly susceptible to radiation damage. We have developed robust computer-aided semiautomatic segmentation and fiber tracking tools to facilitate the ROI delineation of critical structures, which is important for assessment of radiation damage in a longitudinal fashion.

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Section: Iiic1 Longitudinal Percentage Changes In Diffusion Indicesmentioning

confidence: 98%

Radiation therapy effects on white matter fiber tracts of the limbic circuit

et al. 2012

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“…Decreased FA is common in white matter injury, typically attributed to its association with an increased radial diffusivity (λr); this is observed in periventricular white matter in hydrocephalus, posterior reversible encephalopathy syndrome, peritumoral edema (10), and mitochondrial disease (13). A few disease states are reported in which a decreased FA is associated with decreased axial diffusivity (λa), including radiation injury (21). However, we identified few disease states reported with an increased axial diffusivity, the pattern we observed in this study.…”

Section: Pediatric Diabetic Ketoacidosismentioning

confidence: 99%

Change in fractional anisotropy during treatment of diabetic ketoacidosis in children

et al. 2013

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BACKGROUND:The pathophysiology resulting in cerebral edema in pediatric diabetic ketoacidosis (DKA) is unknown. To investigate the changes in white matter microstructure in this disease, we measured diffusion tensor imaging (DTI) parameters, including apparent diffusion coefficient (ADC), fractional anisotropy (FA), and radial and axial diffusivity in children with DKA at two time points during treatment. METHODS: A prospective observational study was conducted at Seattle Children's Hospital, Seattle, WA. Thirty-two children admitted with DKA (pH < 7.3, bicarbonate < 15 mEq/l, glucose > 300 mg/dl, and ketosis; 11.9 ± 3.2 y; and 47% male) were enrolled and underwent two serial paired diffusion magnetic resonance imaging (MRI) scans following hospital admission. Seventeen of the 32 participants had diffusion tensor images of adequate quality for tract-based spatial statistics (TBSS) analysis. RESULTS: TBSS mapping demonstrated main white matter tract areas with a significant increase in FA and areas with a significant decrease in ADC, from the first to the second MRI. Both radial and axial diffusivity terms showed change, with a diffuse pattern of involvement. CONCLUSION: Consistent DTI changes occurred during DKA treatment over a short time frame. These findings describe widespread water diffusion abnormalities in DKA, supporting an association between clinical illness and DTI markers of microstructural change in white matter.

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“…It is commonly used to evaluate the WM in rodent models. 4,19,20 2) It has been reported that the EC is a major WM damage region in the mild-HI-injury neonatal rat model, 4,18 whereas mild HI insult produces a relative sparing injury of GM. …”

Section: Image Analysismentioning

confidence: 99%