Longitudinal genetic analysis of anxiety sensitivity.

Zavos, Helena; Gregory, Alice M.; Eley, Thalia C.

doi:10.1037/a0024996

Cited by 49 publications

(54 citation statements)

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“…[9] However, in stark contrast to the literature on the effect of stressful life events and depression; that on anxiety in general, and anxiety sensitivity in particular is very minimal. In the only previous study to specifically examine stressful life events, they were found to be associated with subsequent increases in anxiety sensitivity.…”

Section: Introductionmentioning

confidence: 44%

Anxiety Sensitivity in Adolescence and Young Adulthood: The Role of Stressful Life Events, 5httlpr and Their Interaction

et al. 2012

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Background: Cognitive biases have long been hypothesized to influence the development and maintenance of symptoms of internalizing problems. Anxiety sensitivity represents one such bias and refers to sensitivity to the physical and emotional symptoms of anxiety and the belief that these are harmful. Twin studies indicate a role for both environmental and genetic influences on anxiety sensitivity. However, little work has been done specifying environments or genes involved in this phenotype. In light of this, we looked at the association between stressful life events, the serotonin transporter gene polymorphism (5HTTLPR), and anxiety sensitivity in a longitudinal sample of adolescents. Methods: Stressful life events and anxiety sensitivity were measured in over 1,500 individuals at three time points (mean ages 15, 17, and 20 years). 5HTTLPR was genotyped in 1,109 participants. Results: There was consistent evidence for an association between stressful life events and both anxiety sensitivity and change in anxiety sensitivity over time. Although the effect of independent stressful life events was relatively short lived, dependent stressful life events were associated with anxiety sensitivity over time. There was no evidence for a main effect of 5HTTLPR on anxiety sensitivity. 5HTTLPR genotype did not moderate the effect of stressful life events on anxiety sensitivity. Conclusions: The current study extends previous work by showing that stressful life events, independent of the individual, explained change in cognitions associated with anxiety and depression. This effect does not, however, appear to be moderated by genotype. Depression and Anxiety 29:400-408, 2012.C 2012 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 44%

Anxiety Sensitivity in Adolescence and Young Adulthood: The Role of Stressful Life Events, 5httlpr and Their Interaction

et al. 2012

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“…14.21 ± 3.48 14.32 ± 3.76 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] 0 13.55 ± 6.04 14.02 ± 6.41 0.427 (Z = -0.79) 13.53 ± 6.03 14.23 ± 6.50 0.249 (Z = -1. 14.56 ± 3.95 14.12 ± 3.54 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] 0.447 (Z = -0.76)…”

Section: B a I A P 3 I S A S S O C I A T E D W I T H A N X I E T Y A unclassified

“…To evaluate whether Baiap3 genotype would affect the propensity for di- D 1 9 : 1 3 5 -1 4 8 , 2 0 1 3 14.42 ± 3.70 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] 0.680 (Z = -0.41)…”

Section: Baiap3 Ko Mice Have An Increased Seizure Propensitymentioning

confidence: 99%

“…Online address: http://www.molmed.org doi: 10.2119/molmed.2013. 00033 tional and varies by the type of anxiety (16), genetically determined anxiousness personality traits may make the development of an addiction more likely (2,(17)(18)(19). The recommended first-line pharmacological treatments of anxiety disorders are selective serotonin or serotonin/norepinephrine reuptake inhibitors and the calcium channel modulator pregabaline (6).…”

Section: Introductionmentioning

confidence: 99%

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Genetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender Specifically Associated with Anxiety and Benzodiazepine Abuse in Mice and Humans

Wojcik

Tantra

Stepniak

et al. 2013

Mol Med

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Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together. Unfortunately, treatment of anxiety disorders still includes benzodiazepines, and patients with an existing comorbid benzodiazepine use disorder or a genetic susceptibility for benzodiazepine use disorder may be at risk of adverse treatment outcomes. The identification of genetic predictors for anxiety disorders, and especially for benzodiazepine use disorder, could aid the selection of the best treatment option and improve clinical outcomes. The brain-specific angiogenesis inhibitor I-associated protein 3 (Baiap3) is a member of the mammalian uncoordinated 13 (Munc13) protein family of synaptic regulators of neurotransmitter exocytosis, with a striking expression pattern in amygdalae, hypothalamus and periaqueductal gray. Deletion of Baiap3 in mice leads to enhanced seizure propensity and increased anxiety, with the latter being more pronounced in female than in male animals. We hypothesized that genetic variation in human BAIAP3 may also be associated with anxiety. By using a phenotype-based genetic association study, we identified two human BAIAP3 single-nucleotide polymorphism risk genotypes (AA for rs2235632, TT for rs1132358) that show a significant association with anxiety in women and, surprisingly, with benzodiazepine abuse in men. Returning to mice, we found that male, but not female, Baiap3 knockout (KO) mice develop tolerance to diazepam more quickly than control animals. Analysis of cultured Baiap3 KO hypothalamus slices revealed an increase in basal network activity and an altered response to diazepam withdrawal. Thus, Baiap3/BAIAP3 is gender specifically associated with anxiety and benzodiazepine use disorder, and the analysis of Baiap3/BAIAP3-related functions may help elucidate mechanisms underlying the development of both disorders.

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“…Anxiety-related temperamental traits, such as anxiety sensitivity (AS) and trait anxiety (Eysenck, 1992; Reiss, Peterson, Gursky, & McNally, 1986), have consistently been found to be predictive of anxiety disorders and symptoms in youth (McLaughlin, Stewart, & Taylor, 2007; Muris, Schmidt, Merckelbach, & Schouten, 2001; Schmidt, Zvolensky, & Maner, 2006; Schmidt et al, 2010; Weems et al, 2007), particularly panic disorder symptoms (Hayward, Killen, Kraemer, & Taylor, 2000; Schmidt et al, 2006). Such temperamental traits are considered developmentally stable risk factors for anxiety (Garcia et al, 2013; Zavos, Gregory, & Eley, 2012; Zavos, Rijsdijk, & Eley, 2012). …”

Section: Introductionmentioning

confidence: 99%

No gene-by-environment interaction of BDNF Val66Met polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample

Martin

Hemmings

Kidd

et al. 2018

European Journal of Psychotraumatology

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Background: Anxiety disorders in youth are attributable to multiple causal mechanisms, comprising biological vulnerabilities, such as genetics and temperament, and unfavourable environmental influences, such as childhood maltreatment (CM).Objective: A gene-environment (G x E) interaction study was conducted to determine the interactive effect of the BDNF Val66Met polymorphism and CM to increase susceptibility to anxiety sensitivity (AS) in a sample of mixed race adolescents.Method: Participants (n = 308, mean age = 15.8 years) who were all secondary school students and who completed measures for AS and CM were genotyped for the BDNF Val66Met polymorphism. Hierarchical multiple regression analysis was conducted to assess G x E influences on AS. Age and gender were included in the models as covariates as age was significantly associated with AS total score (p < .05), and females had significantly higher AS scores than males (p < .05).Results: A main effect of CM on AS was evident (p < .05), however, no main effect of BDNF genotype on AS was observed (p > .05). A non-significant G x E effect on AS was revealed (p < .05).Conclusions: Our results suggest that CM does not have a moderating role in the relationship between the BDNF Val66Met genotype and the increased risk of anxiety-related phenotypes, such as AS. Given the exploratory nature of this study, findings require replication in larger samples and adjustment for population stratification to further explore the role of BDNF Val66Met and CM on AS in mixed race adolescents.

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Longitudinal genetic analysis of anxiety sensitivity.

Abstract: Longitudinal genetic analysis of anxiety sensitivity 2 2 Abstract Background. Anxiety sensitivity is associated with both anxiety and depression and has

Cited by 49 publications

References 48 publications

Anxiety Sensitivity in Adolescence and Young Adulthood: The Role of Stressful Life Events, 5httlpr and Their Interaction

Anxiety Sensitivity in Adolescence and Young Adulthood: The Role of Stressful Life Events, 5httlpr and Their Interaction

Genetic Markers of a Munc13 Protein Family Member, BAIAP3, Are Gender Specifically Associated with Anxiety and Benzodiazepine Abuse in Mice and Humans

No gene-by-environment interaction of BDNF Val66Met polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample

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