Longitudinal melanonychia on multiple nails induced by hydroxyurea

Nguyen, Anh Ly; Körver, J.E.M.; Theunissen, Chantal C W

doi:10.1136/bcr-2016-218644

Cited by 13 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 The prevalence of melanonychia is reported to be 1% in the general population, 10 whereas the estimated risk in patients receiving HU is 3.4%, with the condition more often observed in female patients. 11 The reported occurrence of HU-associated skin hyperpigmentation and melanonychia ranged from 7 weeks to 5 years after the initiation of HU therapy. 12 However, these manifestations were neither dose-dependent nor related to the duration of therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Although HU therapy is considered safe, it could be associated with many side effects, such as nail changes mainly noted as melanonychia, skin hyperpigmentation, and mucocutaneous ulcerations of the oral cavity 9,10 . The prevalence of melanonychia is reported to be 1% in the general population, 10 whereas the estimated risk in patients receiving HU is 3.4%, with the condition more often observed in female patients 11 . The reported occurrence of HU‐associated skin hyperpigmentation and melanonychia ranged from 7 weeks to 5 years after the initiation of HU therapy 12 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral hyperpigmentation associated with hydroxyurea in a patient with polycythemia vera: A case report

Alshammasi

Albasry

Meshikhes

2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral hyperpigmentation associated with hydroxyurea in a patient with polycythemia vera: A case report

Alshammasi

Albasry

Meshikhes

2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…When medical history and clinical findings of our patients examined, it was evaluated that nail changes could be attributed to hydroxyurea. It is demonstrates that an iatrogenic (drug-induced) cause should be considered in the case of longitudinal melanonychia affecting multiple nails [8].…”

Section: Discussionmentioning

confidence: 99%

Melanonychia Caused by Hydroxyurea in Hematologic Patients: Report of 4 Cases

Sd¹

2018

CDOAJ

View full text Add to dashboard Cite

Melanonychia is a nail pigmentation disorder which is predominantly seen in female patients treated by hydroxyurea; especially in patients with diagnosed myeloproliferative disorders. Hydroxyurea inhibits DNA synthesis through its action on ribonucleoside diphosphate-reductase, and can be lead to dermatological disorders including mucocutaneous side effects and nail disorders such as onycholysis, onychodystrophy, and melanonychia. The pathogenesis of hydroxyurea-induced melanonychia is not clear. We present the cases of 4 female patients that two of four patients with diagnosed as polycythaemia rubravera and two of four patients with diagnosed as essential thrombocytosis who are developed melanonychia during hydroxyurea therapy. It is emphasized that the side effects of chemotherapeutic drugs should asses carefully by observing the clinical historyin hematologic patients and treatment should modify, although the side effects will quickly disappear with the reduction or discontinuation of the drug.

show abstract

“…Pseudo‐micro‐Hutchinson sign (pigmentation of the cuticle only observable by dermoscopy but invisible to a naked eye) may also be seen (Fig. ) . In melanonychia striata due to melanocytic hyperplasia in the nail matrix, dermoscopy often shows a gray background and regular, parallel, longitudinal, homogeneous brown to black lines which are usually darker than those seen in melanonychia striata due to melanocytic activation .…”

Section: Diagnosis and Diagnostic Studiesmentioning

confidence: 99%

“…Melanonychia striata may result from melanocytic activation or melanocytic hyperplasia (Tables and ) . In most of the cases, melanonychia striata results from melanocytic activation in the nail matrix (an increase in activity of melanocytes with the subsequent increased synthesis of melanin in the nail matrix and subsequent deposition of melanin in the nail plate without a concurrent increase in the number of melanocytes) .…”

Section: Etiologymentioning

confidence: 99%

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century

et al. 2019

View full text Add to dashboard Cite

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate.Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Other causes of melanonychia striata related to melanocytic activation include pregnancy, chronic local trauma, infections, medications, dermatological disorders, endocrine disorders, alkaptonuria, hemochromatosis, porphyria, graft-vs-host disease, Peutz-Jeghers syndrome, and Laugier-Hunziker syndrome. Causes of melanonychia striata associated with melanocytic hyperplasia include nail matrix melanocytic nevus, nail lentigo, and nail apparatus/subungual in situ and invasive melanoma. In most cases, melanonychia striata is a benign condition, especially in children. Consequently, most investigators advocate a wait-and-see approach. Nail apparatus/subungual melanoma should be suspected if there is an abrupt onset after middle age, personal or family history of melanoma, rapid growth, darkening of a melanonychia band, pigment variegation, blurry lateral borders, irregular elevation of the surface, a bandwidth >3 mm, proximal widening, associated nail plate dystrophy, single rather than multiple digit involvement, and periungual spread of pigmentation onto the adjacent cuticle and/or proximal and/or lateral nail folds (Hutchinson sign). Prolonged follow-up is mandatory for early detection of possible malignant changes.

show abstract

Longitudinal melanonychia on multiple nails induced by hydroxyurea

Cited by 13 publications

References 4 publications

Oral hyperpigmentation associated with hydroxyurea in a patient with polycythemia vera: A case report

Oral hyperpigmentation associated with hydroxyurea in a patient with polycythemia vera: A case report

Melanonychia Caused by Hydroxyurea in Hematologic Patients: Report of 4 Cases

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century

Contact Info

Product

Resources

About