Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from
            <scp>SARS‐CoV</scp>
            ‐2 infection

Stute, Nina L.; Szeghy, Rachel E.; Stickford, Jonathon L.; Province, Valesha P.; Augenreich, Marc; Ratchford, Stephen M.; Stickford, Abigail S.L.

doi:10.14814/phy2.15423

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…In the first study that followed 14 young participants from the first to sixth month post-infection, the authors reported a decrease in cfPWV (decrease by 0.82 m/s), SBP (by 11 mmHg), MAP (by 11 mmHg) with time; and no change in time was found for AIx@HR75 [ 40 ]. The second study followed 10 young adults for 6 months after the COVID-19 infection and found that SBP and DBP decreased throughout the study: with SBP decreasing by 15 mmHg and DBP decreasing by 10 mmHg [ 41 ]. Given that both of these longitudinal studies reported participant attrition on very small sample sizes, used inappropriate statistics (mean and standard deviation) to describe the distribution of limited data, and removed outliers from a small sample size [ 40 ], the reported results could be the result of methodological issues.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Podrug

Koren

Maras

et al. 2023

JCM

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COVID-19-associated vascular disease complications are primarily associated with endothelial dysfunction; however, the consequences of disease on vascular structure and function, particularly in the long term (> 7 weeks post-infection), remain unexplored. Individual pre- and post-infection changes in arterial stiffness as well as central and systemic hemodynamic parameters were measured in patients diagnosed with mild COVID-19. As part of in-laboratory observational studies, baseline measurements were taken up to two years before, whereas the post-infection measurements were made 2–3 months after the onset of COVID-19. We used the same measurement protocol throughout the study as well as linear and mixed-effects regression models to analyze the data. Patients (N = 32) were predominantly healthy and young (mean age ± SD: 36.6 ± 12.6). We found that various parameters of arterial stiffness and central hemodynamics—cfPWV, AIx@HR75, and cDBP as well as DBP and MAP—responded to a mild COVID-19 disease. The magnitude of these responses was dependent on the time since the onset of COVID-19 as well as age (pregression_models ≤ 0.013). In fact, mixed-effects models predicted a clinically significant progression of vascular impairment within the period of 2–3 months following infection (change in cfPWV by +1.4 m/s, +15% in AIx@HR75, approximately +8 mmHg in DBP, cDBP, and MAP). The results point toward the existence of a widespread and long-lasting pathological process in the vasculature following mild COVID-19 disease, with heterogeneous individual responses, some of which may be triggered by an autoimmune response to COVID-19.

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Section: Discussionmentioning

confidence: 99%

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Podrug

Koren

Maras

et al. 2023

JCM

View full text Add to dashboard Cite

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“…On the other hand, Stute et al [70] performed study assesing the impact of SARS-CoV-2 on sympathetic neural activity and hemodynamics over 6 months following SARS-CoV-2 infection. Sympathetic neural parameters was estimated using the microneurographic technique, muscle sympathetic nerve activity (MSNA) and transduction was calculated using an open-source program by O'Brien et al [101].…”

Section: Studies Suggesting a Transient Increase In Bp Following An A...mentioning

confidence: 99%

Elevated Arterial Blood Pressure as a Delayed Complication Following COVID-19 -Systemic Review

Bielecka,

Sielatycki,

Pietraszko

et al. 2023

Preprint

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Hypertension is one of the most common and significant cardiovascular risk factor. With the emergence of COVID-19, concerns have arisen about its potential to exacerbate cardiovascular morbidity and mortality. Several theories have emerged linking hypertension with COVID-19. However, the relationship between SARS-CoV-2 infection and long-term risk of hypertension remains insufficiently explored. Therefore, our study aimed to investigate the impact of COVID-19 infection on blood pressure and long-term risk of hypertension developing. A comprehensive search was conducted in the PubMed and SCOPUS databases up to 10th August 2023 for relevant papers. The analysis included 35 eligible articles. The majority of the latest studies pointed to increase BP after COVID-19 infection. However, several observations contradicted the influence of SARS-CoV-2 on the hypertension development or suggesting a transient effect. The possible role of the loss of angiotensin-converting enzyme 2, cytokine storm, increased sympathetic activity, and endothelial dysfunction were considered. On the other hand, BP changes following COVID-19 could be a consequence of lifestyle changes, which often accompanied COVID-19 infection. Our findings highlight the urgent need for comprehensive research on the COVID-19 and hypertension link. These insights are crucial for implementing effective prevention and management strategies for individuals with the history of COVID-19 infection.

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“…The Big Ten Conference later published its registry data of 1,597 athletes, which identified that 2.3% of athletes infected with SARS-CoV-2 developed clinical and subclinical myocarditis ( Daniels et al, 2021 ). Following these initial ( Nandadeva et al, 2021 ; Ratchford et al, 2021 ; Stute et al, 2021 ) and follow-up studies ( Stute et al, 2022 ), the question of whether any alterations in autonomic or vascular function exist in collegiate athletes following SARS-CoV-2 infection remains unanswered and is the purpose for the present investigation.…”

Section: Introductionmentioning

confidence: 99%

Autonomic and vascular function testing in collegiate athletes following SARS-CoV-2 infection: an exploratory study

et al. 2023

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Introduction: Recent studies suggest that SARS-CoV-2 infection alters autonomic and vascular function in young, otherwise healthy, adults. However, whether these alterations exist in young competitive athletes remains unknown. This study aimed to assess the effects of COVID-19 on cardiac autonomic control and vascular function in collegiate athletes who tested positive for COVID-19, acknowledging the limitations imposed by the early stages of the pandemic.Methods: Sixteen collegiate athletes from various sports underwent a battery of commonly used autonomic and vascular function tests (23 ± 9, range: 12–44 days post-infection). Additionally, data from 26 healthy control participants were included.Results: In response to the Valsalva maneuver, nine athletes had a reduced early phase II blood pressure response and/or reduced Valsalva ratio. A depressed respiratory sinus arrhythmia amplitude was observed in three athletes. Three athletes became presyncopal during standing and did not complete the 10-min orthostatic challenge. Brachial artery flow-mediated dilation, when allometrically scaled to account for differences in baseline diameter, was not different between athletes and controls (10.0% ± 3.5% vs. 7.1% ± 2.4%, p = 0.058). Additionally, no differences were observed between groups when FMD responses were normalized by shear rate (athletes: 0.055% ± 0.026%/s-1, controls: 0.068% ± 0.049%/s-1, p = 0.40).Discussion: Few atypical and borderline responses to autonomic function tests were observed in athletes following an acute SARS-CoV-2 infection. The most meaningful autonomic abnormality being the failure of three athletes to complete a 10-min orthostatic challenge. These findings suggest that some athletes may develop mild alterations in autonomic function in the weeks after developing COVID-19, while vascular function is not significantly impaired.

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Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV ‐2 infection

Cited by 7 publications

References 57 publications

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

Elevated Arterial Blood Pressure as a Delayed Complication Following COVID-19 -Systemic Review

Autonomic and vascular function testing in collegiate athletes following SARS-CoV-2 infection: an exploratory study

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