Longitudinal Optical Density Analysis of Subretinal Fluid After Surgical Repair of Rhegmatogenous Retinal Detachment

Kashani, Amir H; Cheung, Albert Y.; Robinson, Joshua; Williams, George A.

doi:10.1097/iae.0000000000000267

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…We demonstrated that reflectivity ratios can be used as diagnostic markers to differentiate between retinal pathologies. Kashani et al 24 used the same method to investigate changes in the OD of the SRF after RRD repair. They found that ODR measurements increase significantly over time after surgery, and might reflect an increased concentration of photoreceptor OS fragments in the SRF as the serous component is absorbed.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study of the SRF after surgical repair of RRD did not find ODR to be a significant predictor of visual acuity. 24 To the best of our knowledge, and based on a careful search of PubMed.com (1988-2014, [in the public domain] http://www.ncbi.nlm.nih.gov/pubmed), this appears to be the first study to describe the relationship between preoperative measurement of ODR in RRD and visual outcome. As discussed above, OD is influenced by changes in fluid composition.…”

Section: Discussionmentioning

confidence: 99%

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Optical Density of Subretinal Fluid in Retinal Detachment

Leshno

Barak

Loewenstein

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optical Density of Subretinal Fluid in Retinal Detachment

Leshno

Barak

Loewenstein

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…14 In another study, optical density ratios from OCT scans were used as a surrogate measure of SRF composition Table 3 Final visual acuities, foveola ellipsoid zone (EZ), and external limiting membrane (ELM) scores for patients in whom PSF was found on OCT and subsequently absorbed (resolved PSF group), compared with patients in whom subfoveolar fluid was not found on the first post-operative OCT scan (non-PSF group) following surgery. 16 This ratio increased in conjunction with a decrease in height of subretinal fluid and was suggested to reflect an increasing particulate concentration of subretinal fluid during the process of subretinal fluid absorption. 16 Retinal detachments secondary to atrophic holes and dialyses are not dependent upon development of a PVD.…”

Section: Discussionmentioning

confidence: 99%

“…16 This ratio increased in conjunction with a decrease in height of subretinal fluid and was suggested to reflect an increasing particulate concentration of subretinal fluid during the process of subretinal fluid absorption. 16 Retinal detachments secondary to atrophic holes and dialyses are not dependent upon development of a PVD. 17 They frequently present when acute symptomatic progression of a chronic asymptomatic peripheral detachment occurs.…”

Section: Discussionmentioning

confidence: 99%

Persistent subfoveolar fluid following retinal detachment surgery: an SD-OCT guided study on the incidence, aetiological associations, and natural history

Tee

Veckeneer

Laidlaw

2016

Eye

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Purpose To investigate the incidence and natural history of persistent subfoveolar fluid (PSF) following surgery for macular off rhegmatogenous retinal detachment and the effect of PSF on photoreceptor structure and final visual acuity. Methods Retrospective study of 61 cases with post-operative optical coherence tomography (OCT) performed within 12 weeks of surgery. Based on aetiology, cases were categorized into tractional retinal tears (TRT) group or atrophic round holes and dialyses (RHD) group to investigate the incidence and duration of PSF. A Kaplan-Meier graph was plotted to compare survival time of subfoveolar fluid for both groups. Following secondary reclassification of cases into those with and without PSF, the effect of PSF on final visual acuity and photoreceptor structure was investigated with Mann-Whitney U-test used for comparison. Spearman's correlation testing was used to probe associations between time to recorded resolution of PSF with final visual acuity and photoreceptor structure. Results Incidence of PSF was greater in the RHD group and persisted for longer compared with TRT group. No detectable adverse effect of PSF on final visual acuity was seen however an individual case of severe photoreceptor atrophy was observed. No significant correlation was found between the time to recorded resolution of PSF and the final visual acuity or to photoreceptor grading scores. Conclusions A difference in incidence of PSF was detected between the aetiological groups. PSF was ubiquitous and slow to resolve in the RHD group. Most cases of PSF resolve without adverse sequelae; however, progressive photoreceptor atrophy and sub-optimal visual outcome may result in a minority.

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“…The application of SD-OCT, FAF, mfERG, and microperimetry are a major step forward in this direction but it is likely that additional tests of RPE health will be necessary to understand the biochemical and pharmacologic function of the cells after transplantation. For example, quantitative FAF, 22 in vivo, real-time spectroscopy, 109,110 and a host of SD-OCT-based measures of tissue composition [111][112][113] present promising technology that can resolve cellular and molecular changes in retinal tissue. 114 Identification and quantification of outcome parameters in cell-based therapies will also be challenging.…”

Section: Considerations For Surgical Implantationmentioning

confidence: 99%

Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration

Kashani

2016

Invest. Ophthalmol. Vis. Sci.

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Age-related macular degeneration (ARMD) is the leading cause of blindness in subjects older than 50 years of age in the developed world. There are two types of ARMD, neovascular (NV) and nonneovascular (NN). While anti-VEGF-based therapies have significantly decreased the visual morbidity associated with NV-ARMD, there are no effective treatments for NN-ARMD. A detailed discussion of NV-ARMD and related therapies is the topic of another section of this special supplement. This review will focus mainly on NN-ARMD. Vision loss in nonneovascular ARMD is highly correlated with the loss of RPE cells and areas of geographic atrophy (GA). Pilot studies using subretinal transplantation of autologous or allogeneic RPE during the past 20 to 30 years have demonstrated that stem cell-derived RPE have the potential to rescue photoreceptor function and restore vision. New methods of differentiating RPE from human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) have created a potentially unlimited supply of RPE cells to meet the demands of future commercially viable stem cell products. Thanks to fundamental advances in stem cell biology, vitreoretinal surgery, and noninvasive retinal imaging, stem cell-based therapies for NN-ARMD are emerging and several clinical trials are in progress. However, there are major regulatory, safety, and technical challenges that remain. This review will focus on summarizing the most promising aspects of stem cell-based therapy for NN-ARMD and highlighting areas that require further research.

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Longitudinal Optical Density Analysis of Subretinal Fluid After Surgical Repair of Rhegmatogenous Retinal Detachment

Abstract: Changes in optical density ratios of the residual SRF after retinal detachment repair may be representative of changes in the SRF composition over time. This is in agreement with previous biochemical studies and may serve as a noninvasive method of assessing SRF content in vivo.

Cited by 18 publications

References 24 publications

Optical Density of Subretinal Fluid in Retinal Detachment

Optical Density of Subretinal Fluid in Retinal Detachment

Persistent subfoveolar fluid following retinal detachment surgery: an SD-OCT guided study on the incidence, aetiological associations, and natural history

Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration

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