Longitudinal pattern of early maturation on morning cortisol and depressive symptoms: Sex-specific effects

Sun, Ying; Yang, Liu; Yan, Shuangqin; Hu, Jingjing; Xu, Geng; Liu, Jiang; Tao, Fangbiao

doi:10.1016/j.psyneuen.2016.04.026

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…In boys, an earlier age at puberty was considered as a risk factor for testicular cancer . A one-year follow-up study reported that newly onset early maturation was associated with having depressive symptoms in boys . Very early puberty in boys was associated with self-reported depression .…”

Section: Discussionmentioning

confidence: 99%

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Relationships of Pyrethroid Exposure with Gonadotropin Levels and Pubertal Development in Chinese Boys

Pan

Zhao

et al. 2017

Environ. Sci. Technol.

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Although an acceleration of male pubertal development has been observed, precisely which endocrine-disrupting chemicals (EDCs) might contribute to the advancing onset of puberty in boys remains unclear. Here, pyrethroids, a class of widely used insecticides that have been considered as EDCs, are proposed as new environmental risk factors. In this study, 463 boys at the age of 9-16 years old were recruited in Hangzhou, Zhejiang, China. The common metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), as well as gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), were analyzed in urine samples. Pubertal development was assessed based on Tanner stages and testicular volume (TV). A positive association between 3-PBA and gonadotropins was found (p < 0.001), in which a 10% increase in 3-PBA was associated with a 2.4% and 2.9% increase in LH and FSH, respectively. Higher urinary levels of 3-PBA in boys were associated with 275% and 280% increase in the risk of being genitalia stage 3 (G3) and G4, respectively (p < 0.05). There was a significant (132%) induction in odd of being TV 12-19 mL with increasing 3-PBA concentration compared to being in TV < 4 mL (p < 0.05). For the first time to our knowledge, this work reports on an association of increased pyrethroid exposure with elevated gonadotropins levels and earlier pubertal development in boys.

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Section: Discussionmentioning

confidence: 99%

“…18 A one-year follow-up study reported that newly onset early maturation was associated with having depressive symptoms in boys. 35 Very early puberty in boys was associated with selfreported depression. 36 In addition, boys with an early maturation exhibit an increased incidence of behavior disorders.…”

Section: ■ Discussionmentioning

confidence: 99%

Relationships of Pyrethroid Exposure with Gonadotropin Levels and Pubertal Development in Chinese Boys

Pan

Zhao

et al. 2017

Environ. Sci. Technol.

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“…However, there is evidence that the influence of puberty processes on the associations between HPA axis activity with stress and depressive symptoms is best accounted for by assessing pubertal status and timing (e.g. refs 76 – 78 ). Future studies of HCC in adolescents should consider including those measures.…”

Section: Limitationsmentioning

confidence: 99%

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel

Streit

Zhu

et al. 2017

Sci Rep

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Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.

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“…In addition, the timing of puberty has been identified as a critical factor in mental health, with deviations from normative development placing an individual at greater risk for psychopathology (for reviews, see Mendle & Ferrero, ; Mendle, Turkheimer, & Emery, ; Waylan & Wolke, ; Weichold, Silbereisen, & Schmitt‐Rodermund, ). There is extensive evidence that early pubertal maturation is linked to greater levels of anxiety, depression, eating pathology, and risky or anti‐social behavior in girls (Belsky, Ruttle, Boyce, Armstrong, & Essex, ; Caspi, Lynam, Moffitt, & Silva, ; Mendle et al, ; Reardon, Leen‐Feldner, & Hayward, ; Sun et al, ). For boys, the research has been more limited but there is evidence to support the suggestion that deviations from the normative timing (i.e., either early or late maturation) are associated with negative outcomes such as substance abuse, disruptive behavior disorders, and increased symptoms of depression (Graber, Seeley, Brooks‐Gunn, & Lewinsohn, ; Mendle & Ferrero, ; Sun et al, ; Weichold et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…There is extensive evidence that early pubertal maturation is linked to greater levels of anxiety, depression, eating pathology, and risky or anti‐social behavior in girls (Belsky, Ruttle, Boyce, Armstrong, & Essex, ; Caspi, Lynam, Moffitt, & Silva, ; Mendle et al, ; Reardon, Leen‐Feldner, & Hayward, ; Sun et al, ). For boys, the research has been more limited but there is evidence to support the suggestion that deviations from the normative timing (i.e., either early or late maturation) are associated with negative outcomes such as substance abuse, disruptive behavior disorders, and increased symptoms of depression (Graber, Seeley, Brooks‐Gunn, & Lewinsohn, ; Mendle & Ferrero, ; Sun et al, ; Weichold et al, ). Of course, the correlational nature of these studies means that such shifts in pubertal timing may actually be a consequence of poor mental health (a possibility supported by at least one study that found anxiety at 8 years of age to be predictive of early menarche; Tremblay & Frigon, ) or a secondary symptom of some other common causal factor(s).…”

Section: Introductionmentioning

confidence: 99%

Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation

Cowan

Richardson

2018

Developmental Psychobiology

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Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress.

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Longitudinal pattern of early maturation on morning cortisol and depressive symptoms: Sex-specific effects

Cited by 4 publications

References 20 publications

Relationships of Pyrethroid Exposure with Gonadotropin Levels and Pubertal Development in Chinese Boys

Relationships of Pyrethroid Exposure with Gonadotropin Levels and Pubertal Development in Chinese Boys

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation

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