Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis

Twiss, Jacob; Stewart, Alistair; Byrnes, Catherine A

doi:10.1136/thx.2005.047332

Cited by 72 publications

(57 citation statements)

References 32 publications

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“…Although there has been limited longitudinal research focused on bronchiectasis determinants in patients with CF (4), cross-sectional and short-term studies suggest that bronchiectasis correlates with significantly increased airways obstruction (8,9). In addition, Evans et al (6) reported that patients with bronchiectasis "who become colonized by P aeruginosa have poorer lung function when first colonized than those colonized by other organisms."…”

mentioning

confidence: 99%

Association between MucoidPseudomonasInfection and Bronchiectasis in Children with Cystic Fibrosis

Farrell

Collins²,

Broderick³

et al. 2009

Radiology

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Purpose:To correlate the severity of bronchiectasis in children with cystic fibrosis with clinical and microbiologic variables in order to clarify risk factors for the development of irreversible lung disease. Materials and Methods:After institutional review board approval and parental informed consents were obtained, a HIPAA-compliant longitudinal epidemiologic evaluation was performed in patients with cystic fibrosis who were enrolled in the Wisconsin trial of newborn screening from 1985 to 2009. Thinsection chest computed tomography (CT) was used in a prospective cross-sectional design to study patients ranging in age from 6.6 to 17.6 years (mean, 11.5 years). Thin-section CT scores were determined objectively on coded images by multiple raters in a standardized fashion. Microbiologic data were obtained by means of culture of respiratory secretions by using methods for differentiation of Pseudomonas aeruginosa (PA) as either nonmucoid or mucoid. Results:Eighty-three percent of patients (68 of 82) showed bronchiectasis of varying severity. Of 12 potential risk factors, only respiratory infection with mucoid PA correlated significantly with bronchiectasis (P ϭ .041). Conclusion:The severity of bronchiectasis in children with cystic fibrosis is significantly related to respiratory infection with mucoid PA; attempts to prevent bronchiectasis should include reducing exposure to and early eradication of PA. Note: This copy is for your personal, non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, use the Radiology Reprints form at the end of this article. Patients with cystic fibrosis (CF) are susceptible in early childhood to chronic lung disease associated with recurrent respiratory infections due to unusual respiratory pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa (PA) (1). At a variable age, patients with CF will develop obstructive pulmonary dysfunction (2). In addition, the majority of children with CF show structural bronchopulmonary abnormalities (3-5), including bronchiectasis, mucous plugging, peribronchial thickening, air trapping, and parenchymal opacities. Bronchiectasis is an early and prominent feature of CF lung disease. Bronchiectasis is considered an irreversible abnormality (4,6) and thus indicates the presence of permanent damage to the lungs. Chronologically, bronchiectasis is the first irreversible change seen in children with CF (7). Because the identification of bronchiectasis indicates that treatment can no longer be expected to return the status of the lungs to normal, the prevention of bronchiectasis is of great importance in the care of the child with CF.Although there has been limited longitudinal research focused on bronchiectasis determinants in patients with CF (4), cross-sectional and short-term studies suggest that bronchiectasis correlates with significantly increased airways obstruction (8,9). In addition, Evans et al (6) reported that patients with bronchiectasis "who become colonized by P aeruginosa hav...

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mentioning

confidence: 99%

Association between MucoidPseudomonasInfection and Bronchiectasis in Children with Cystic Fibrosis

Farrell

Collins²,

Broderick³

et al. 2009

Radiology

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“…66,67 La evolución de la función difiere según la etiología. Así, pacientes con FQ presentan un descenso más rápido de la función que los no FQ, 68 …”

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“…Bronquio cortado transversalmente con vaso adyacente aunque en ambos se produce su deterioro con el tiempo, con presencia mayoritaria en la edad adulta de un patrón obstructivo. 68 Las indicaciones de fibrobroncoscopía incluyen: afectación de un solo lóbulo pulmonar, cultivo de esputo repetidamente negativo sin respuesta al tratamiento, TACAR compatible con micobacterias atípicas con cultivos de esputo negativos, sospecha de aspiración pulmonar crónica y niños gravemente enfermos para obtener información microbiológica.…”

Section: Figura 1 Imagen En Vía De Tren Bronquio Dilatado Cortado Lunclassified

Bronquiectasias en pediatría, aproximación diagnóstica y tratamiento

et al. 2012

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RESUMENLas bronquiectasias son un problema de salud en países desarrollados y en vías de desarrollo. La fibrosis quística es una causa importante, si bien fuera de ésta existen causas que convierten a las bronquiectasias no relacionadas con fibrosis quística en un diagnóstico frecuente. Su diagnóstico precoz basado en la clínica y posterior confirmación radiológica es el punto de partida para determinar la etiología e instaurar un tratamiento dirigido a la causa subyacente. Para ello es menester una evaluación ordenada y sistemá-tica. Se presenta una revisión sobre la etiología y tratamiento de las bronquiectasias, especialmente de las no relacionadas con fibrosis quística. Palabras clave: bronquiectasias, fibrosis quística, antibióticos, infección bronquial, diagnóstico. SUMMARYBronchiectasis is still an important health problem in both, developed and developing countries. Cystic fibrosis is one of the most important causes, but a great variety of other causes makes non cystic fibrosis bronchiectasis a relatively frequent diagnosis. Early diagnosis based on medical history and radiological confirmation is only the starting point to determine the specific etiology, in order to establish a treatment focused on the underlying cause. For this purpose, an orderly and systematic diagnostic evaluation is required. A review article about bronchiectasis, particularly those not related to cystic fibrosis, is presented.

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“…Both adults and children have been shown to develop progressively worsening airfl ow obstruction [42][43][44]. As bronchodilation is the key diagnostic feature, bronchiectasis is often not considered to be an obstructive lung disease.…”

Section: Lung Functionmentioning

confidence: 99%

Pathogenesis and diagnosis of bronchiectasis

King

Daviskas

2010

breathe

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 To describe the important factors involved in the pathogenesis of bronchiectasis.  To define how a diagnosis of bronchiectasis is made. SummaryBronchiectasis is an important cause of respiratory morbidity but one that has generally had a low profile. The prevalence of this condition varies but is common in certain indigenous populations and, anecdotally, in developing nations. It also has been recently recognised to be an ongoing problem in developed countries. As bronchiectasis is heterogeneous with a large number of predisposing factors and, generally, a long clinical history, the pathogenesis has not been well defined. The combination of a microbial insult and a defect in host defence allow the establishment of persistent bronchial infection and inflammation leading to progressive lung damage. Lung function testing usually demonstrates a mild to moderate obstructive pattern, which arises from inflammation in the small airways. There are a number of risk factors associated with this condition, which is commonly idiopathic. The microbiology of bronchiectasis is complex and changes as the disease progresses. The diagnosis is made by a combination of clinical symptoms and high-resolution computed tomography (HRCT) demonstrating abnormal airway dilatation.

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Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis

Cited by 72 publications

References 32 publications

Association between MucoidPseudomonasInfection and Bronchiectasis in Children with Cystic Fibrosis

Association between MucoidPseudomonasInfection and Bronchiectasis in Children with Cystic Fibrosis

Bronquiectasias en pediatría, aproximación diagnóstica y tratamiento

Pathogenesis and diagnosis of bronchiectasis

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