Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI

Maheswaran, Satheesh; Barjat, Hervé; Rueckert, Daniel; Bate, Simon T.; Howlett, David; Tilling, Lorna; Smart, Sean; Pohlmann, Andreas; Richardson, Jill C.; Hartkens, Thomas; Hill, Derek L. G.; Upton, Neil; Hajnal, Jo; James, Michael F.

doi:10.1016/j.brainres.2009.02.045

Cited by 94 publications

(92 citation statements)

References 43 publications

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“…While it is known that the volume of the hippocampus decreases with age [38,44,45], we did not observe a significant decline in hippocampal volume in our group of healthy subjects. Longitudinal studies have demonstrated that there is whole-brain, and especially hippocampal, atrophy with age which correlates with a decline in cognition [46].…”

Section: Discussioncontrasting

confidence: 38%

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Chen

Strauss²,

Hayes³

et al. 2015

Stereotact Funct Neurosurg

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Objective: White matter diffusivity measures of the fornix change with aging, which likely relates to changes in memory and cognition in older adults. Subregional variations in forniceal diffusivity may exist, given its heterogeneous anatomy and connectivity; however, these have not been closely examined in vivo. We examined diffusivity parameters (fractional anisotropy, FA; radial diffusivity, RD; axial diffusivity, AD) in forniceal subregions of healthy subjects and correlated them with age and hippocampal volume. Methods: Diffusion-weighted imaging and streamline tractography of the fornix were performed on 20 healthy, right-handed females (23-66 years). Six anatomical subregions were defined: midline (body, column, precommissural fornix) or lateral (fimbria, crura, postcommissural fornix). Regression analysis was performed comparing diffusivities against age. Hippocampal and ventricular volumes were also compared. Results: Diffusivity values revealed statistical changes with age in both midline and lateralized subregions. The fornix body and left crus showed age-related alterations in all metrics (FA, RD, AD), whereas only right crus FA was altered. There was no significant change in hippocampal volumes, suggesting that forniceal changes may precede hippocampal age-related changes. Conclusions: Age-related changes in fornix diffusivity measures appear subregion dependent and asymmetrical. Specific subregion diffusivity measures may be a more sensitive aging marker than hippocampal volume change.

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Section: Discussioncontrasting

confidence: 38%

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Chen

Strauss²,

Hayes³

et al. 2015

Stereotact Funct Neurosurg

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“…There are conflicting results in the literature regarding hippocampal changes in different mouse models of AD. While some authors reported decreased hippocampal volume in the PDA␤PP or the A␤PP/PS1 mice [44,45], others reported enlarged hippocampus in the TASTPM mice [46]. Thus, genetic background or transgene expression, as well as other factors such as the age of animals or even the method of measurement, may play a role in the differences found.…”

Section: Discussionmentioning

confidence: 82%

Systematic Evaluation of Magnetic Resonance Imaging and Spectroscopy Techniques for Imaging a Transgenic Model of Alzheimer's Disease (AβPP/PS1)

Esteras

Alquézar

Antequera

et al. 2012

JAD

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Abstract. Murine models of Alzheimer's disease (AD) provide means to detect and follow biomarker changes similar to those observed in humans. Non-invasive biomarkers, such as those provided by magnetic resonance imaging (MRI) and spectroscopy (MRS) methods are highly desirable, however, systematic studies of in vivo MRI/MRS methods to characterize the cerebral morphology and metabolic pattern of these mice remain scarce. We investigated sixteen consecutive slices from the brain of wild-type and A␤PP/PS1 mice, obtaining a collection of T 2 -weighted, diffusion weighted and magnetization transfer weighted images as well as 1 H PRESS spectra from the cortical and subcortical areas. Compared to controls, A␤PP/PS1 mice show significant regional hyperintensities in T 2 -weighted images of the cerebral cortex, significant ventricular enlargement, and decreased hippocampal area and fractional magnetization transfer. MRS demonstrated an increase in the ratio of choline (Cho) to creatine (Cr) in the cortical and subcortical areas of the transgenic animals. A logistic regression classifier was implemented considering all parameters investigated, and revealed the most characteristic changes and allowed for the correct classification of control and A␤PP/PS1 mice. In summary, the present results provide a useful frame to evaluate optimal MRI/MRS biomarkers for the characterization of AD models, potentially applicable in drug discovery processes, because of their non-invasive and repeatable nature in longitudinal studies.

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“…analysis. The brain volume changes are measured by M.R.I (Dierks et al 2000;Sunderland et al 2003;Maheswaran et al 2009;Luckhaus et al 2010) 9 .…”

Section: Introductionmentioning

confidence: 99%

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

Mahajan

Votruba

2017

Acta Ophthalmologica

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Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of senile dementia. It impairs the quality of life of a person and their family, posing a serious economic and social threat in developed countries. The fact that the diagnosis can only be definitively made post‐mortem, or when the disease is fairly advanced, presents a serious problem if novel therapeutic interventions are to be devised and used early in the course of the disease. There is therefore a pressing need for more sensitive and specific diagnostic tests with which we can detect AD in the preclinical stage. The tau proteins and beta‐amyloid proteins start to accumulate 20 years before the symptoms begin to manifest. Detecting them in the preclinical stage would be a potential breakthrough in the management of AD. A high degree of clinical suspicion is needed to correlate problems in cognition with the changes in the eye, particularly the retina, pupil and ocular movements, so that the disease can be detected early and managed in the prodromal phase. In this systematic review, we ask the question whether the retina can be used to make a specific and early diagnosis of AD.

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Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI

Cited by 94 publications

References 43 publications

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Age-Related Changes in Diffusion Tensor Imaging Metrics of Fornix Subregions in Healthy Humans

Systematic Evaluation of Magnetic Resonance Imaging and Spectroscopy Techniques for Imaging a Transgenic Model of Alzheimer's Disease (AβPP/PS1)

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

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